Protein Alignment PEX10 and Pex10

DIOPT Version :10

• Sequence 1: NP_722540.1
• Gene: PEX10 / 5192
• HGNCID: 8851
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_647624.1
• Gene: Pex10 / 38182
• FlyBaseID: FBgn0035233
• Length: 299
• Species: Drosophila melanogaster
• Alignment Length: 348
• Identity: 105/348 - (30%)
• Similarity: 160/348 - (45%)
• Gaps: 61/348 - (17%)

Human     4 AAASPPEVIRAAQKDEYYRGGLRSAAGGALHSLAGARKWLEWRKEVELLSDVAYFGLTTLAGYQT 68
            |.|..||::|:.|||..|...|.......|. |.|.|.|:::.:...||::::|.|..:....||
  Fly     6 ARARQPEIVRSVQKDARYTNELAEDLSDVLR-LTGPRNWIKYNQMCRLLAELSYHGFASANNLQT 69

Human    69 LGEEYVSIIQVDPSRIHVPSSLRRGVLVTLHAVLPYLLDKALLPLEQELQADPDSGRPLQGSLGP 133
            |||||..|||||.:...:||.|    |..:..||.:..|.....|.|:|.....:...::..:.|
  Fly    70 LGEEYTGIIQVDGNYKQIPSRL----LQLIAIVLEFGGDSLFQRLMQKLDTYVANNDEIRTEIKP 130

Human   134 GGRGCSGARRWMRHHTATLTEQQRRALLRAVFVLRQGLACLQRLHVAWFYIHGVFYHLAKRLTGI 198
                                 |.::.:.|    |||..:.::.||.:.||:....|.|:||.|||
  Fly   131 ---------------------QLKKIIQR----LRQSPSYVKALHKSLFYLDASKYQLSKRTTGI 170

Human   199 TYQALR----PDPLRVLMSVAPSALQLRVRSLPGEDLRARVSYRLLGVISLLHLVLSMGLQLY-G 258
            .|..:|    |:                 .||.|        |::||||:.|.:.:|:.:..: .
  Fly   171 NYVLIRHWLQPE-----------------FSLYG--------YKILGVITFLQVSVSLAISGWDA 210

Human   259 FRQRQRARKEWRLHRGLSHRRASLEERAVSRN-PLCTLCLEERRHPTATPCGHLFCWECITAWCS 322
            :|:.:|.:.|.....|.:..:.|...:.|..| |.|.||||.|...:.|||||:|||.|:..|..
  Fly   211 WREHKRQQLESIKQAGKNFLQRSSSTKDVDPNTPQCILCLEPRSDSSLTPCGHIFCWSCLLEWLE 275

Human   323 SKAECPLCREKFPPQKLIYLRHY 345
            .:.|||||||.....::|.|::|
  Fly   276 ERDECPLCRESLKKSQVILLQNY 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX10	NP_722540.1	Pex2_Pex12	18..263	CDD:398431	65/249 (26%)
		RING-HC_PEX10	293..342	CDD:438190	24/48 (50%)
Pex10	NP_647624.1	Pex2_Pex12	20..>173	CDD:398431	51/182 (28%)
		HRD1	<183..>287	CDD:227568	41/111 (37%)
		RING-HC_PEX10	244..295	CDD:438190	25/50 (50%)