Protein Alignment PEX6 and PEX6

DIOPT Version :10

• Sequence 1: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Sequence 2: NP_014070.1
• Gene: PEX6 / 855387
• SGDID: S000005273
• Length: 1030
• Species: Saccharomyces cerevisiae
• Alignment Length: 654
• Identity: 239/654 - (36%)
• Similarity: 344/654 - (52%)
• Gaps: 105/654 - (16%)

Human   398 SAYLADTTHTSLYMVGST-LSPVPWLPSE-------ESTLWSSLSPPGLEALVSELCAVLKPRLQ 454
            |.::.|...|.|.....| ..|:|...|.       ..|.:..|.   :...|.:|..:|:....
Yeast   405 SHFIIDPNRTKLITTNITNRRPLPLSRSNLQRYYGFAETFYYDLH---IFPYVRQLVNILETSFN 466

Human   455 PGGALLTGTSSVLLRGPP-GCGKTTVVAAACSHLGLHLLKVPCSSLCAESS---------GAVET 509
            .....:|..:||||.... ..||.|:|..|..:||:|||::.|.||.:.|.         |.:..
Yeast   467 CSQRGITLNASVLLHSTTNNVGKATMVRFASKYLGIHLLEIDCLSLTSNSRQLDSTSKIIGYIRA 531

Human   510 KLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDP--------LN---- 562
            |.:.:...|   .|||:.|..:|                ::|..:..|:||        :|
Yeast   532 KCENVLPYA---SPAVIFLAHLD----------------SILLDVNANQDPEAIKLQKSINFEMS 577

Human   563 --------SCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILR-ALTAH------- 611
                    ..|....|.:.:...::|:..::....|:.||..||.|||.|.: .|::|
Yeast   578 KLLDDFTFKFPGTTFVGSVNNIDNVPSSFRSHMRFEILVPVPSEAQRLRIFQWYLSSHELNRDVQ 642

Human   612 --LPLG--QEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRI-KNSGLAGGLTEEDEGELCAAG 671
              :|:.  ..::.:.|:...||....|:.:::..:...|..|. :.|...|.|.:         .
Yeast   643 QKVPVSYMDNISFSSLSSYSAGLTPLDIKSIVETARMTATARFYQESKKCGWLPQ---------S 698

Human   672 FPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGL- 735
            ..:..||..:|..:.:...|.::|||:||:|:|.|:||:..||.|||:||.:||:||||.:.|:
Yeast   699 ILITQEDLSKATSKARNEFSVSIGAPQIPNVTWDDIGGIDFVKGEILDTIDMPLKHPELFTSGMK 763

Human   736 RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCII 800
            :|||:|.:|||||||||:|||:||..||.|.|||||||:|||:|:||.|||.||.:||.|.||:|
Yeast   764 KRSGILFYGPPGTGKTLMAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQKAREAKPCVI 828

Human   801 FFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRF 864
            ||||:||:||.||..|||||||||:||||||||||:.:..| ||||||||||||||.||||||||
Yeast   829 FFDEIDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRF 893

Human   865 DKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR 929
            |||:::|..:....||.:|.|:||||.|:..|.|:.:...||...||||.|:||||||..|:.|.
Yeast   894 DKLLYLGIPDTDTKQLNILEALTRKFVLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRI 958

Human   930 VHDLEEGLEPGS---------------------SALMLTMEDLLQAAARLQPSVSEQELLRYKRI 973
            ...:|:.:...:                     :.:::.|||.|:|..:|.||||..||..|:.:
Yeast   959 ARMVEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYEAV 1023

Human   974 QRKF 977
            :..|
Yeast  1024 RANF 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX6	NP_000278.3	CDC48	<466..977	CDD:273521	223/576 (39%)
PEX6	NP_014070.1	CDC48	<541..1021	CDD:273521	199/500 (40%)
		RecA-like_PEX6_r2	740..899	CDD:410935	110/160 (69%)