Protein Alignment PEX6 and prx-6

DIOPT Version :10

• Sequence 1: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Sequence 2: NP_504268.1
• Gene: prx-6 / 266912
• WormBaseID: WBGene00004195
• Length: 720
• Species: Caenorhabditis elegans
• Alignment Length: 716
• Identity: 214/716 - (29%)
• Similarity: 348/716 - (48%)
• Gaps: 140/716 - (19%)

Human   286 LEMGELRIQR-------------------------YLEGSIAPEDKGSCSLLPGPPFARELHIEI 325
            :::|.|||.|                         :.|..|...:....||:..|..|:.:.:|
 Worm    95 VKIGSLRISRCDVFNLFGPDLVKNVAVDNITPNFKFHETPIPISEDAKLSLMRQPSVAKNIRLE- 158

Human   326 VSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSPEKLPRWREMFFKVKKTVG 390
               .|:         |.:..:...|..:.||:.:......         ..:...:|:|:
 Worm   159 ---KHH---------LKQILKSANVFYKNDVIRITNYNAY---------TDKTTHLFYKL----- 197

Human   391 EAPDGPASAYLADTTHTSLYMVGSTLSPVPW---------LPSEESTLWSSLSPPGLEALVSELC 446
               |..:|..:.|:: |::|...:....:|:         ..|..:|::........:..:|:..
 Worm   198 ---DVSSSPCIMDSS-TAVYETSAVSQSLPFSNFLLKNSLTSSMRTTVFRMTQIYSAQKTISKKA 258

Human   447 AVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKL 511
            .||         |:||.|        |.||..:.....|....:..:|....:..|::...|.|.
 Worm   259 LVL---------LVTGAS--------GSGKRLMSRVFASETHRNFFEVDGYEMVCENASTSEAKW 306

Human   512 QAIFSRARRCRPAVLLLTAVDLLGRDR-DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVV--ATT 573
            .:.:.:|:..:..||.:...::|..|: :.|  |.|::..:      |..|:....:.|:  ..|
 Worm   307 TSWWEKAKLLQNCVLFIRNSNVLAIDQFNAL--DRRILQYM------EQKLSEPSKITVIFSCNT 363

Human   574 SRAQDLPADVQTAFPHELEVPALSEGQRLSILR-----ALTAHLPLGQEVNLAQLARRCAGFVVG 633
            .....:||:|:....:......:.|..|.:.|:     .|..|           :|::.:||.:.
 Worm   364 DTMSSMPANVKNLALYTFSAEFMDENDRKTWLQYYLNEKLANH-----------VAKKTSGFTLA 417

Human   634 DLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPK 698
            :|..|:.:..:..             .||.|.::           :...:::..:..:.|:||||
 Worm   418 ELEKLVKNGKKVK-------------IEEKEEKV-----------YEDLIDKRNSNFADAIGAPK 458

Human   699 IPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSL 763
            ||:|.|.|||||:|.|:.:||:|:..|    ..|..|:|||::|:|.||.||||:|||||||..:
 Worm   459 IPNVRWEDVGGLEETKQTVLESIRTNL----FGSRALKRSGIILYGSPGCGKTLIAKAVATEFKI 519

Human   764 TFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQ 828
            .|||||||||:|.||||||||:|:||.||:.|:||:|||||:|||||:|||:||||||:||:|||
 Worm   520 AFLSVKGPELLNKYVGQSEENLRKVFERAKQASPCVIFFDEIDSLAPNRGRNGDSGGVIDRIVSQ 584

Human   829 LLAELDGLHST--QDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFK 891
            ||||||.||::  ..|||:||||||||||.:|:.||||||||.|...||..|:.::|.|::||.:
 Worm   585 LLAELDKLHNSPLTKVFVMGATNRPDLLDNSLMTPGRFDKLVEVKPGEDVESKTKILEAVSRKMR 649

Human   892 LEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAA 956
            .|..|.|..:......:::||.|:|:.|:|..||:...:..:|:| :..:.::.:....||::..
 Worm   650 FEEDVDLREIASKVDEKMSGAQLFSIISNAGMAAIVETIQSIEDG-KTENQSIRVAQRHLLESVK 713

Human   957 R 957
            |
 Worm   714 R 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX6	NP_000278.3	CDC48	<466..977	CDD:273521	180/502 (36%)
prx-6	NP_504268.1	AAA	261..363	CDD:459627	24/126 (19%)
		RPT1	451..715	CDD:440835	144/269 (54%)