Protein Alignment PEX6 and pex6

DIOPT Version :10

• Sequence 1: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Sequence 2: NP_593468.1
• Gene: pex6 / 2542437
• PomBaseID: SPAC17A5.01
• Length: 948
• Species: Schizosaccharomyces pombe
• Alignment Length: 664
• Identity: 240/664 - (36%)
• Similarity: 363/664 - (54%)
• Gaps: 68/664 - (10%)

Human   351 VQEGDVLCVP------TIGQVEILEGSPEKLPRWRE--MFFKVKKTVGEAPDGPASAYLADTTHT 407
            :|...:.|||      ....|:|||     |.|..:  :::.|::.      .|.:.|....|:.
pombe   317 LQSKQIFCVPINSLMANSDSVDILE-----LTRNTDAYIWYSVEEI------DPLNTYNIYYTNE 370

Human   408 SLYMVGSTLSPVPWLPSEESTL--WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGTSSVLLR 469
            ...:|..|......|||....|  :..:.||..:.|  ..| |...|:..||     .....||.
pombe   371 DTSIVLDTQLSHRLLPSLRKPLLNFVKVHPPSQKLL--RFCRAFFDPQQVPG-----FNPFFLLH 428

Human   470 GPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLL 534
            |.|..|||..|....|.....:..:........::..:|.||........:...|::.:..:|:|
pombe   429 GNPFTGKTKAVEEVASLFSAPVFTISSYEFADATADHLEAKLDMFVQNVVKSPCAIIFVKDLDVL 493

Human   535 GRDRDGLGEDARVMAVLR--HLLLNEDPLNSCPP--LMVVATTSRAQDLPADVQTAFPHELEVPA 595
            ....|    :..::...:  .:||::..|...|.  .:|:.|....:.:|.::.:....||:...
pombe   494 SISSD----EGNIVPGSKSIQILLSKIDLVKSPQGRYIVIGTCHSIEKIPYEILSESFFELKFSE 554

Human   596 LSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLT 660
            |...:||.:|:....::.:.:.::|..:|.:......|:|..|..|.::||..|||.:|.
pombe   555 LEMDERLELLKIYANNVIIDKRISLKDVALKTNSMSFGELECLPDHMTKAAVDRIKRTGY----- 614

Human   661 EEDEGELCAAGFPLLAE-DFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLP 724
              |...:..:| |::.| |...::.:::...|..:..  :|.|:|.|:|||:|.|..:.:|:|||
pombe   615 --DNDSIILSG-PIITEQDVDVSINRIRKEKSNTIFT--VPKVNWDDIGGLEEAKTVLRDTLQLP 674

Human   725 LEHPELLSLGLR-RSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREV 788
            |:.|||.|.||: |||:||:|||||||||||||||||.||.|:|:|||||:|||||:||.|||.|
pombe   675 LQFPELFSQGLKPRSGVLLYGPPGTGKTLLAKAVATELSLEFVSIKGPELLNMYVGESEANVRNV 739

Human   789 FARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRP 851
            |.:||.::||:||||||||:||.||.|.|||.||||||||||||||.:....:  ||||||||||
pombe   740 FEKARNSSPCVIFFDELDSIAPHRGNSSDSGNVMDRVVSQLLAELDSISKDNNKYVFVIGATNRP 804

Human   852 DLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYS 916
            |||||:|||||||||||::|.|:...|:..:|.|:|:.|||:.::.|..:...|.|..||||:|:
pombe   805 DLLDPSLLRPGRFDKLVYLGINKSEESKASMLRALTKTFKLDETIDLNEIAKNCHPNFTGADMYA 869

Human   917 LCSDAMTAALKRRVHDLEEGLEPG-----------------SSALMLTMEDLLQAAARLQPSVSE 964
            |||||:.:|:||:.::::..::..                 |..|.:|.||.|.:..:|:||:||
pombe   870 LCSDAVLSAIKRKTNEIDLLIQASGTDLSTEEFFKRNENQDSLELRITKEDFLTSLKKLRPSISE 934

Human   965 QELLRYKRIQRKFA 978
            |||.||:.::.:|:
pombe   935 QELHRYEMVRHQFS 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX6	NP_000278.3	CDC48	<466..977	CDD:273521	211/535 (39%)
pex6	NP_593468.1	CDC48	<426..941	CDD:273521	210/528 (40%)