Protein Alignment PEX1 and PEX1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_012724.1
• Gene: PEX1 / 853636
• SGDID: S000001680
• Length: 1043
• Species: Saccharomyces cerevisiae
• Alignment Length: 1309
• Identity: 356/1309 - (27%)
• Similarity: 553/1309 - (42%)
• Gaps: 349/1309 - (26%)

Human    19 VAFTNA-RDCFLHLPRRLVAQLHLLQNQAIE----VVWSHQP----AFLSWVEGRHFSDQGENVA 74
            :.|:|| ...||.||..::..|. ..|.||:    .|.||..    ..|.| :| |.|...|||.
Yeast    14 IQFSNAIVGNFLRLPHSIINVLE-STNYAIQEFGIAVHSHNSDIPIVHLGW-DG-HDSGSSENVV 75

Human    75 EIN------RQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQ-HLLD 132
            .||      ..:.||..|.:   ::::...|.....:|.|.|.::|||||::.:|:..:. .:|.
Yeast    76 LINPVLATVYDLNQKSPLVD---LYIQRYDHTHLATEVYVTPETSDDWEIIDANAMRFQNGEILH 137

Human   133 QIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYK 197
            |.|||.|......:::.....| :|..:.|:....|:...:.:::.||..:.:   ..||:
Yeast   138 QTRIVTPGETLICYLEGIVTKF-KIDRVEPSMKSARITDGSLVVVAPKVNKTR---LVKAE---- 194

Human   198 KLHSYGRDQKGMMK----ELQTKQLQSNTVGITESNENESEIPVDS------SSVASLWTMIG-- 250
                ||...|.::|    :|..|.:..:||       .:.:.|.|:      |..|.|.:..|
Yeast   195 ----YGHSNKTILKNGAIQLLKKVILRSTV-------CKMDFPKDNLFVVYISDGAQLPSQKGYA 248

Human   251 SIF--SFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIH 313
            ||.  |.:..||.::.      |....:.||.:   .:|..|.||.|           ..|.|:.
Yeast   249 SIVKCSLRQSKKSDSD------NKSVGIPSKKI---GVFIKCDSQIP-----------ENHIALS 293

Human   314 VFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEED 378
            ...||..:                                        :.|::..||:.:
Yeast   294 SHLWDAFF----------------------------------------THPMNGAKIKLE----- 313

Human   379 EKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPR 443
                .||:....:....||     .|.:.:.||
Yeast   314 ----FLQMNQANIISGRNA-----TVNIKYFGK-------------------------------- 337

Human   444 SLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWE 508
                    ::|....::      ||.|...:.....|::..|:.| :|.|.|            |
Yeast   338 --------DVPTKSGDQ------YSKLLGGSLLTNNLILPTEQII-IEIKKG------------E 375

Human   509 KEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILP-FLKLSSLGGVNSLGVSSLEHITH 572
            .|:.    |.:.|.:...::|..:..|.|||..:.|:..|| ...:...|.|:.......:.||.
Yeast   376 SEQQ----LCNLNEISNESVQWKVTQMGKEEVKDIIERHLPKHYHVKETGEVSRTSKDEDDFITV 436

Human   573 SLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAH--VERVDCKAL-RG 634
            :.:.:.:...|.|.:  :...|::|.|.:|.||:.|.|.:..|.  :.|.|  |:..||:.| ..
Yeast   437 NSIKKEMVNYLTSPI--IATPAIILDGKQGIGKTRLLKELINEV--EKDHHIFVKYADCETLHET 497

Human   635 KRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAV---QSQRLAHALNDMI 696
            ..|:..||.:....|...|..||:::||:::.:.|.|...:.:.|.:..   .|:.|...:|.:.
Yeast   498 SNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNGQWDNASKLLNFFINQVT 562

Human   697 KEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVI-KN---KL 757
            |.|......:.::.:.:.:..::|||...   |.......::.|::..|.::|.... ||   ||
Yeast   563 KIFNKDNKRIRVLFSGKQKTQINPLLFDK---HFVSETWSLRAPDKHARAKLLEYFFSKNQIMKL 624

Human   758 DCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHS-RLSR--QSISTREKLVLTTLDFQKALR 819
            :.|: :|:||.|     ||.||...|..:..::..:. :|.|  .::.|||.       |.|:|.
Yeast   625 NRDL-QFSDLSL-----ETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTREL-------FSKSLS 676

Human   820 GFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPG 884
            .|.|::||.|.|.|..::.|..||.|...:.:|::|::.|.||..:|.|.|:|.|:||||||.||
Yeast   677 AFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPG 741

Human   885 TGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRR 949
            .||||||..:|::..:|||||||||:|:|:||||||.:|::|.|||:.||||||||||:||||:|
Yeast   742 CGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKR 806

Human   950 GHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRL 1014
            |||:||||||||||||||:||.|||.|||:|||||||||||.||||||||||.|.|..|.:..||
Yeast   807 GHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERL 871

Human  1015 EILNVLSDS---------LPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQD 1070
            :||..:.:|         ..|..:.||:.:|..|..|:||||:.|.|||.|:::|..|
Yeast   872 DILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWL------- 929

Human  1071 GSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYE 1135
                                     ||.|             .||::|.......:.:
Yeast   930 -------------------------SAAD-------------QSEVVPGNDNIEYFSI------- 949

Human  1136 SELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRT-ASQEGCQELTQEQRDQLRAD 1199
            :|.|....:.|..:.|     :.||:              |..| .|.....|||
Yeast   950 NEHGRREENRLRLKTL-----LQQDV--------------VHETKTSTSAASELT---------- 985

Human  1200 ISIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESFQNPK 1264
                                       ..::.:.|:.|...|:||||..:......:|:.||
Yeast   986 ---------------------------AVVTINDLLEACQETKPSISTSELVKLRGIYDRFQ--- 1020

Human  1265 RRKNQSGTM 1273
              |:::|.|
Yeast  1021 --KDRNGEM 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	27/93 (29%)
		PEX-1N	104..179	CDD:462729	19/75 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		1/20 (5%)
		CDC48	<595..1065	CDD:273521	204/491 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283		5/14 (36%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:462729	18/75 (24%)
		CDC48	<401..1023	CDD:273521	219/644 (34%)
		RecA-like_PEX1_r2	705..862	CDD:410934	45/163 (28%)