Protein Alignment PEX1 and pex1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_001164306.1
• Gene: pex1 / 793906
• ZFINID: ZDB-GENE-070530-1
• Length: 1237
• Species: Danio rerio
• Alignment Length: 1291
• Identity: 619/1291 - (47%)
• Similarity: 838/1291 - (64%)
• Gaps: 87/1291 - (6%)

Human    17 VTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWS-HQPAFLSWVEGRHFSDQGENVAEINRQV 80
            ||:.|.|:::|||||.......|.|.:||.:|:.|. ..|.||||:..|  |...|:..||:||:
Zfish    10 VTLVFNNSKNCFLHLSSNFATHLCLHENQILELSWGVSAPVFLSWIRSR--SSGPEDRVEISRQL 72

Human    81 GQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPKAIFPV 145
            |:||||.:|.|.:|:||..|.|.|||.|||||.|||||||||:::|||.:|||||:||...:|||
Zfish    73 GEKLGLRDGEQGYLRPCLQVQSVQQVSVEPLSPDDWEILELHSLALEQRILDQIRVVFSDGVFPV 137

Human   146 WVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKGMM 210
            ||||.|.|:|:|.:|.|:..|||||..|:|::.||.....| ...|..:|..:.|
Zfish   138 WVDQHTVIYIRIASLTPSVPYGRLEQFTELIVSPKLHPGSE-LLHKPQSEEPRQH---------- 191

Human   211 KELQTKQLQSNTVGITESNENESEIPVDSS-----SVASLWTMIGSIFSFQSEKKQETSWGLTEI 270
               |...:.|:::. ..|.:::::.|...:     .:|.|..::..:|:...|..:|
Zfish   192 ---QNVNITSSSIS-NASQDSQNDHPESLNEGHWGGIADLKGLVRYLFTRGREPAKE-------- 244

Human   271 NAFKNMQSKVVPL---DNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWD-QEYFDVEP-SFTV 330
                .:....:|.   |.|.|.|.|.|.|:.:..:.     |..:|:.||: ||..:..| ...:
Zfish   245 ----KIAVPTIPAILKDCILRTCGSPPRSVSHHGSC-----HGDVHILPWNLQEQENWNPGQSAL 300

Human   331 TYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIR-SDHNEED-----EKACVLQVVWN 389
            |||:|.|:||||:.:.|.||             .:::|||| :.|.|:|     |.:.|::::.:
Zfish   301 TYGRLSKILSPKELREKVKQ-------------AMEKKKIRDASHKEKDTEEHMENSAVVRMLCH 352

Human   390 GLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLP 454
            .:..|....|..| .|.::.||:|||..|::||.|::|:.|||.|::..|::..::.:||.:.|.
Zfish   353 NINRLQEDQKLNK-CEEIYSGKIWIPKMLQRRLKIDLHSAVRIQPLKSMPRLAETVMVQPLQPLA 416

Human   455 KDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLS 519
            :...||||:..|.:|....:...|..:......|.|...:|.:||:|:::.. |::::..:|.||
Zfish   417 ESEKEEDIQMAFLNWFDAQSHQPLTCLTGRSNIILLPCAEGKEEFALTVLKP-EQQQEDELFFLS 480

Human   520 PNLLQKTTIQVLLDPMVKE----ENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLS 580
            .:||:||.||:..:|...:    :|..| |..|.|..|||||||..:..|:.:||:|:|||..||
Zfish   481 NSLLRKTDIQIAREPHNSDHRGSDNDTE-DQCLGFPSLSSLGGVEDISRSAFQHISHALLGGSLS 544

Human   581 RQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLE 645
            |:|:|...|||.||||:||.||||||:|::|:|::|.:.||||::.:|||.|:|||.:.|::.||
Zfish   545 RELISTGRGLRGGALLITGAKGSGKSSLSRALCRKASEDLDAHIQLLDCKTLKGKRTDTIRQRLE 609

Human   646 VAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIA 710
            ..|.:|||.|||||||||||.:||....|||||.|:||..|.::.:|.|::.|.:...||:|||.
Zfish   610 DVFEQAVWRQPSVVLLDDLDHVAGAATSPEHEHGPEAVLRQHISQSLKDLVDEIVLRSSLIALIV 674

Human   711 TSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVI--KNKLDCDINKFTDLDLQHVA 773
            |:|::.:|||.|...||.|.||....|..|:|.||.|||.::|  |:...|.    |.|||..||
Zfish   675 TAQTEHALHPTLTVVQGSHFFQSFCKIPTPDQAQRVEILKSLIVKKSFQVCQ----TTLDLDSVA 735

Human   774 KETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLG 838
            |||.||:|||..:|::||||:.....|..      |:..||::||:||.|.||....|..|...|
Zfish   736 KETEGFMARDLNLLLERAIHANTLHNSED------LSCKDFRQALQGFTPPSLWDAQLQAPSGAG 794

Human   839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFI 903
            .::||||||.||:|||.|.||||||.||::||:||.:|:||||.||||||||||.:|:||.||||
Zfish   795 MERIGGLHEARQLLMDIILLPAKYPLLFSSLPLRQCSGVLLYGAPGTGKTLLAGAVAKESGMNFI 859

Human   904 SVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQL 968
            |:|||||||||||||||||||:|.|||.|||||||||||:|:|||||||||||||||||||||||
Zfish   860 SIKGPELLSKYIGASEQAVRDVFQRAQQAKPCILFFDEFDSLAPRRGHDNTGVTDRVVNQLLTQL 924

Human   969 DGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQ 1033
            ||||||.|||||||:||||||||||||||||||.:||||||:.:|||||..|:.|:|||.||||.
Zfish   925 DGVEGLTGVYVLAASSRPDLIDPALLRPGRLDKSLYCPPPDREARLEILRALTHSVPLAADVDLD 989

Human  1034 HVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAG 1098
            .:|..|:.|||||||||||||||||:|..|..:.|.|..|.||||:||||::|||||||||||||
Zfish   990 QIAGATELFTGADLKALLYNAQLEAIHSSLGPNLLHDLGSGSDSDVSLSSLIFLNHSSGSDDSAG 1054

Human  1099 DGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPG 1163
            :|:.||:.|:|.||.||:.|::.:.|::|||||||:||||.|   ..|:|||||.|:|...||.|
Zfish  1055 EGDAGLEHSMVLLEPSELPPEDPRHNIWRLYFGSSFESELDN---QSLNSQCLSGPNSTAPDLTG 1116

Human  1164 VPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGRYRSQSGE-DESMNQPGPIKTRL 1227
            ...:|......||..:..|:|.|||:.||.::|||::|.:|..||..:.| ..|:.|..|.|...
Zfish  1117 ASVRDPSSCHAPVFMSCVQQGFQELSHEQSERLRAEVSTVKNSYRKTTDESSSSLVQTSPSKPGS 1181

Human  1228 AISQSHLMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA 1283
            .|.|:||.|||.:||.|:|.:|||.:.||||||..||.||:||..:|:.||:||||
Zfish  1182 LICQTHLTTALANTRASVSREDWKRYTELYESFGAPKERKSQSNVLFKAGQRVTLA 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	36/81 (44%)
		PEX-1N	104..179	CDD:462729	47/74 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		3/20 (15%)
		CDC48	<595..1065	CDD:273521	294/471 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283		12/22 (55%)
pex1	NP_001164306.1	PEX-2N	10..89	CDD:462730	35/80 (44%)
		PEX-1N	101..171	CDD:462729	43/69 (62%)
		CDC48	<559..1020	CDD:273521	293/470 (62%)