Protein Alignment PEX1 and pex1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: XP_004915478.1
• Gene: pex1 / 779516
• XenbaseID: XB-GENE-985415
• Length: 1269
• Species: Xenopus tropicalis
• Alignment Length: 1294
• Identity: 670/1294 - (51%)
• Similarity: 891/1294 - (68%)
• Gaps: 42/1294 - (3%)

Human     7 LAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQ-PAFLSWVEGRHFSDQG 70
            :.|.|..||||::..|:|:|.||.:...::|||.|.|..|:||.||.| |.:|.|:|.|..:...
 Frog     1 MLGPGPPGAAVSLKLTSAKDTFLRVTPEVLAQLRLEQKHAVEVSWSDQEPVYLCWMERRSGTCSR 65

Human    71 ENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIR 135
            .||||:|||.|:.||.|:|.|||||.|::|:||::|.||||:||||:|||||:.:||..||||||
 Frog    66 TNVAELNRQFGEILGFSDGQQVFLKQCTNVISCKEVTVEPLTADDWDILELHSSALESRLLDQIR 130

Human   136 IVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKA-------D 193
            ||:||||||||||..|.|::||.||.|.:||||||..|:|::.||.|..:  |.|.|       |
 Frog   131 IVYPKAIFPVWVDPHTCIYLQIGALTPQSSYGRLEPLTELIVAPKQRNLE--TISPAFIPPGPED 193

Human   194 AEYKKLHSYGRDQKGMMKELQTKQLQ-SNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQS 257
            .:....|     :|...|:.:|...| .:|.|  ||...||:.....||..|:|..:|.......
 Frog   194 LDVNFSH-----EKSDHKQSRTADSQRQSTEG--ESGPTESDHSDSLSSSKSIWDTVGDFLLRSL 251

Human   258 EKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYF 322
            .:|...|.|.:|....|....|.|.|:.:|||....|..:.::...:.:.....:|||.|..|..
 Frog   252 GRKPALSLGSSETELIKKSLVKKVELEAVFRVSSRIPHIVKSSQEYNDYANDNCVHVFLWYPEPP 316

Human   323 DVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVV 387
            .:.|...||:|.:.:|||||:::..|::|....||:.....|...|:..||....   :..:::|
 Frog   317 GLVPDIVVTFGTIQELLSPKRRKESTRKNTEPSEKKPDGIAPGSPKQRNSDTKGH---SATVKIV 378

Human   388 WNGLEELNNAIKY-TKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRE 451
            |:|.::|.:.|:| |:|... |:||||:|..|||:|||.:.:.|||...:...::|.||.|||.:
 Frog   379 WHGFDDLKDVIEYDTRNGNT-HVGKVWVPSQLRKKLNINISSAVRIHSHDSVLRLPTSLTLQPAQ 442

Human   452 NLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIF 516
            .|.::|.|::||..|.:|||.::|..:|.:.....:|::..||.:.:|.:.:.....:....:.:
 Frog   443 TLDRNIHEDEIKAAFSTWLQSNSTLKMPWIAGNTGYIQIILKDEVSDFFIILDKLDLQSSQDDFY 507

Human   517 LLSPNLLQKTTIQVLLDPMVKEENSEEI--DFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPL 579
            :|.|::::||.|.|..:|...||:...:  |..|.:|||.:||||:.||.|..:|:.|.||||||
 Frog   508 MLCPSIMEKTKIHVNFEPAPSEESHRHLHADQNLLYLKLQNLGGVSKLGKSCYDHVVHCLLGRPL 572

Human   580 SRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTL 644
            ||||::..:|||:|.:||.|.|||||||||||:||||.::|:||||.:|||.|:||.:|||.:||
 Frog   573 SRQLVASASGLRSGGVLLCGPKGSGKSTLAKALCKEASEQLEAHVEEIDCKLLKGKNVENIIQTL 637

Human   645 EVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALI 709
            |.||.||.|.||||:||||||.|||:.:.||.|.||:|.||::||:.|.|::|..|||.:||:||
 Frog   638 EEAFEEAAWRQPSVILLDDLDQIAGVASSPELEQSPEATQSKQLAYVLKDLMKNIISMDTLVSLI 702

Human   710 ATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAK 774
            ||.||:.||:|:|:|.||.|:||||:.|.||.||.|.|:|..||:|:|..|...:.|||.|::|:
 Frog   703 ATCQSEHSLNPVLISEQGTHLFQCVKPIPPPTQENRSEMLRCVIENRLSGDTAFYRDLDFQYLAR 767

Human   775 ETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGW 839
            ||.||||||||:||:|||.|.:|::.|...|.|||:|.|||:||:||.|.|||:..||||:...|
 Frog   768 ETEGFVARDFTMLVERAIESSVSKRQICRIEDLVLSTTDFQRALKGFTPLSLRNAQLHKPKKQDW 832

Human   840 DKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFIS 904
            :.:||||::||:|.|||:|||||||||||||||.|:|:||||.|||||||||||||.||||||||
 Frog   833 NMVGGLHDIRQVLKDTIELPAKYPELFANLPIRHRSGVLLYGAPGTGKTLLAGVIAHESRMNFIS 897

Human   905 VKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLD 969
            :|||||||||||||||||||:|.|||||||||||||||:||||||||||||||||||||:|||||
 Frog   898 IKGPELLSKYIGASEQAVRDVFTRAQAAKPCILFFDEFDSIAPRRGHDNTGVTDRVVNQMLTQLD 962

Human   970 GVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQH 1034
            |||||||||||||||||||||||||||||||:|:|||||||.||.|||..||.|:.|.::|||:|
 Frog   963 GVEGLQGVYVLAATSRPDLIDPALLRPGRLDECLYCPPPDQDSRFEILKGLSHSMLLDENVDLKH 1027

Human  1035 VASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGD 1099
            :||:||.|||||||||||||||||:|..|..:..||.:|.||||:||||::||||||.||||.||
 Frog  1028 IASLTDYFTGADLKALLYNAQLEAIHTNLSVTVPQDNNSGSDSDMSLSSIIFLNHSSASDDSGGD 1092

Human  1100 GECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGV 1164
            .:..||.||.||:|.::..::...:|:|||||:||:|:|||| ||:.:||..|..:|:|.:..|.
 Frog  1093 QDSVLDHSLPSLDMIKLPIEDIHSSMWRLYFGNSYDSDLGNG-SSEQTSQSFSGSNSITHEFTGP 1156

Human  1165 PGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGR-----YRSQSGEDESMNQPGPIK 1224
            ...:.:.|||.|..::|.|..|:.:|||..::..:||:.|..     |.|.| :.||       |
 Frog  1157 TIGELVPSQPLVFISSSPEDHQQHSQEQCQKVDDEISVPKANCMNVVYDSHS-QMES-------K 1213

Human  1225 TRLAISQSHLMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA 1283
            ..|.|.|.||:.||..||||||::|||.|..|||:|:|||:...::   :|.|||||||
 Frog  1214 KSLLIKQHHLLNALASTRPSISQEDWKFFNHLYENFKNPKQSSRET---WRSGQKVTLA 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	39/81 (48%)
		PEX-1N	104..179	CDD:462729	49/74 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		5/20 (25%)
		CDC48	<595..1065	CDD:273521	333/469 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283		10/22 (45%)
pex1	XP_004915478.1	PEX-2N	11..93	CDD:462730	39/81 (48%)
		PEX-1N	99..174	CDD:462729	49/74 (66%)
		CDC48	<587..1052	CDD:273521	330/464 (71%)