Protein Alignment PEX1 and Pex1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_001280735.1
• Gene: Pex1 / 71382
• MGIID: 1918632
• Length: 1284
• Species: Mus musculus
• Alignment Length: 1285
• Identity: 1053/1285 - (81%)
• Similarity: 1150/1285 - (89%)
• Gaps: 3/1285 - (0%)

Human     1 MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSWVEGRH 65
            ||.||||||||.|||.|||||||||||||||||||||||||||||||||...|||.:||||||||
Mouse     1 MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVASDHQPTYLSWVEGRH 65

Human    66 FSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHL 130
            |:||.|||||||||||||||||:|.||||:||||||||||||||||||||||||||||:||||||
Mouse    66 FNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEQHL 130

Human   131 LDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAE 195
            |||||||||||:.|:|||||||||||||.|:|||.||||||:||||||||||:|||:||.|....
Mouse   131 LDQIRIVFPKAVVPIWVDQQTYIFIQIVTLMPAAPYGRLETNTKLLIQPKTRQAKESTFPKEGDA 195

Human   196 YKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKK 260
            :.::|||||:|||:.|||||:||.:|:.|||.||..:.::| ......|.|.::||:.||..:.|
Mouse   196 HGQVHSYGREQKGLSKELQTRQLHTNSEGITASNGRDPKVP-GGPLKPSWWAVLGSMLSFGPDSK 259

Human   261 QETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYFDVE 325
            ||::||..|:.|||||||:..||:..||||:.||||....:|||||||||..|||||||||||||
Mouse   260 QESAWGSLELGAFKNMQSQAAPLEGTFRVCQVQPPSARTTTATSVFHKHCTAHVFPWDQEYFDVE 324

Human   326 PSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNG 390
            |||||||||||||.||||||.|:||.||.|:||||:|:..|.|:|.|:.:||..:||||:|||||
Mouse   325 PSFTVTYGKLVKLHSPKQQQDKSKQGVLLPDKEKQLSKSPDHKQISSNRSEEAAEACVLKVVWNG 389

Human   391 LEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPK 455
            ||||.||.::|:::|:||.|||||||||||||||||||||||||:|.||||||||||||||||||
Mouse   390 LEELKNATEFTESLELLHRGKVWIPDDLRKRLNIEMHAVVRITPLETTPKIPRSLKLQPRENLPK 454

Human   456 DISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKD--KNIFLL 518
            |::||.|||||.||:|||.|||||||||:||.||||.||||:|||||.|||.||||:  |.:|:|
Mouse   455 DVNEETIKTVFSSWVQQSATTMLPLVISKEERIKLEIKDGLREFSLSTVHSQEKEKEEGKTVFVL 519

Human   519 SPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQL 583
            |..||||.::||||:||:|||.|.||||:||.|.|||||||::||.|::||||||||||||||||
Mouse   520 SSILLQKISVQVLLEPMIKEEQSAEIDFLLPSLTLSSLGGVSALGASAMEHITHSLLGRPLSRQL 584

Human   584 MSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAF 648
            |:|||||||||||:||||||||||.||||||||.|.|||.||.||||||||||||:|||.|||||
Mouse   585 MALVAGLRNGALLITGGKGSGKSTFAKAICKEAQDTLDARVETVDCKALRGKRLESIQKALEVAF 649

Human   649 SEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713
            |||.|.||||:||||||||||||:|||.||||:||||||||||||||||||:|.|||||||||||
Mouse   650 SEAAWRQPSVILLDDLDLIAGLPSVPEQEHSPEAVQSQRLAHALNDMIKEFVSTGSLVALIATSQ 714

Human   714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGG 778
            .||||||.||||||:|.||||||:||||.|||||||.:|:||||.|||:.|.|||||.:||:|..
Mouse   715 LQQSLHPSLVSAQGIHTFQCVQHLQPPNPEQRCEILHSVVKNKLGCDISNFPDLDLQCIAKDTEA 779

Human   779 FVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIG 843
            ||||||||||||||||.||||..|:||.|.|||.|||||||||||||||:|||||||||||||||
Mouse   780 FVARDFTVLVDRAIHSSLSRQHSSSREDLTLTTSDFQKALRGFLPASLRNVNLHKPRDLGWDKIG 844

Human   844 GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGP 908
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||.|||||:|||
Mouse   845 GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIKGP 909

Human   909 ELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEG 973
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   910 ELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEG 974

Human   974 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASV 1038
            ||||||||||||||||||||||||||||||||||||||||||||.|||.||.|||||||||||||
Mouse   975 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLALADDVDLQHVASV 1039

Human  1039 TDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECG 1103
            |||||||||||||||||||||.|.||.|||.||.|||||||||||||||||||||||||||||||
Mouse  1040 TDSFTGADLKALLYNAQLEALQGRLLPSGLPDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECG 1104

Human  1104 LDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKD 1168
            |:|||:|||||||||||||||||||||||||||||||||.|||||.|||||||:|||||..||||
Mouse  1105 LEQSLLSLEMSEILPDESKFNMYRLYFGSSYESELGNGTPSDLSSHCLSAPSSVTQDLPAAPGKD 1169

Human  1169 QLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGRYRSQSGEDESMNQPGPIKTRLAISQSH 1233
            .||:|.||.||.||||||:|||||||||||:|||||||||||||||||:||||||||..||||:|
Mouse  1170 PLFTQHPVFRTPSQEGCQDLTQEQRDQLRAEISIIKGRYRSQSGEDESLNQPGPIKTTFAISQAH 1234

Human  1234 LMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA 1283
            |||||.|||||||||:.|.||||||:|||||:|||||||:||.|||||||
Mouse  1235 LMTALAHTRPSISEDEGKEFAELYENFQNPKKRKNQSGTVFRTGQKVTLA 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	70/80 (88%)
		PEX-1N	104..179	CDD:462729	66/74 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		11/20 (55%)
		CDC48	<595..1065	CDD:273521	418/469 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283		19/22 (86%)
Pex1	NP_001280735.1	PEX-2N	17..98	CDD:462730	70/80 (88%)
		PEX-1N	104..179	CDD:462729	66/74 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..373		21/33 (64%)
		CDC48	<596..1061	CDD:273521	415/464 (89%)
		RecA-like_PEX1_r2	849..1006	CDD:410934	152/156 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1261..1284		19/22 (86%)