Protein Alignment PEX1 and Pex1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_001102690.1
• Gene: Pex1 / 500006
• RGDID: 1559939
• Length: 1283
• Species: Rattus norvegicus
• Alignment Length: 1285
• Identity: 1047/1285 - (81%)
• Similarity: 1143/1285 - (88%)
• Gaps: 4/1285 - (0%)

Human     1 MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSWVEGRH 65
            ||.||||||||.|||.|||||||||||||||||.|||||||||||||||...|||.:||||||||
  Rat     1 MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDHQPTYLSWVEGRH 65

Human    66 FSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHL 130
            |:||.|||||||||||||||||:|.||||:||||||||||||||||||||||||||||:|||:||
  Rat    66 FNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEEHL 130

Human   131 LDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAE 195
            ||||||||||||.|:|||||||||||||||:|.|.||||||:||||||||||:|||:||.|....
  Rat   131 LDQIRIVFPKAIVPIWVDQQTYIFIQIVALMPTAPYGRLETNTKLLIQPKTRQAKESTFPKEGDA 195

Human   196 YKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKK 260
            ..:.|:|||:|||.:||||||||..||..:..||....|:|.||.. ...|.::||:|||..:.|
  Rat   196 RGQAHNYGREQKGTVKELQTKQLHKNTEAVPVSNGRNPEVPGDSVK-PRWWAVLGSMFSFGPDNK 259

Human   261 QETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYFDVE 325
            ||::||..|:.|||||||:.||||:|||||:.||||::|..|.|||||||.:|||||||||||||
  Rat   260 QESAWGSLELGAFKNMQSQTVPLDSIFRVCQVQPPSVHNTPANSVFHKHCTVHVFPWDQEYFDVE 324

Human   326 PSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNG 390
            |||||.|||||||.||||||.|:||.||.||||||:|:....|:|.||.:||..:.|||:|||||
  Rat   325 PSFTVVYGKLVKLHSPKQQQDKSKQGVLLPEKEKQLSQSPGHKRIGSDGSEEAAETCVLKVVWNG 389

Human   391 LEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPK 455
            ||||.||.::||::|.||.||||||.||||||||||||||||||:|.||.|||:|:|||.||||:
  Rat   390 LEELKNATEFTKSLEPLHHGKVWIPADLRKRLNIEMHAVVRITPLETTPVIPRALRLQPAENLPR 454

Human   456 DISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKD--KNIFLL 518
            |:|||::|.||.||||:|.|||.||:||::|.||||.||||||||||||||.||||:  :.:|:|
  Rat   455 DVSEEEVKAVFSSWLQESATTMFPLIISKQECIKLEIKDGLKEFSLSIVHSQEKEKEQGRTVFVL 519

Human   519 SPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQL 583
            ||.||||.::||||:||: .|:|||||.:||.|.|||||||:||.||::||||||||||||||||
  Rat   520 SPILLQKISVQVLLEPMI-GEHSEEIDILLPSLTLSSLGGVSSLSVSAMEHITHSLLGRPLSRQL 583

Human   584 MSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAF 648
            |:|||||||||||:|||||||||||||||||||.|.||||||.||||||||||||:|||.|||||
  Rat   584 MALVAGLRNGALLITGGKGSGKSTLAKAICKEAHDALDAHVEMVDCKALRGKRLESIQKALEVAF 648

Human   649 SEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713
            |||.|.||||:||||||||||||:.|||||||:||||||||||||:|||||:|||||||||||||
  Rat   649 SEAAWRQPSVILLDDLDLIAGLPSTPEHEHSPEAVQSQRLAHALNNMIKEFVSMGSLVALIATSQ 713

Human   714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGG 778
            .|.||||.||||||||.|||:||||||:||||||||.:|:||||.|||:|..||||:.:||||..
  Rat   714 LQHSLHPSLVSAQGVHTFQCIQHIQPPDQEQRCEILHSVVKNKLGCDISKSPDLDLKCIAKETEA 778

Human   779 FVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIG 843
            ||||||||||||||||.||||...|||.|.|||.|||||||||||||||:|||||||||||||||
  Rat   779 FVARDFTVLVDRAIHSSLSRQQNPTREGLTLTTADFQKALRGFLPASLRNVNLHKPRDLGWDKIG 843

Human   844 GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGP 908
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||.|||||::||
  Rat   844 GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIQGP 908

Human   909 ELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEG 973
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   909 ELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEG 973

Human   974 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASV 1038
            ||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||||||||||
  Rat   974 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLPLADDVDLQHVASV 1038

Human  1039 TDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECG 1103
            |:|||||||||||||||||||.|.||..||.||.|||||||||||||||||||||||||||||||
  Rat  1039 TESFTGADLKALLYNAQLEALQGRLLPGGLHDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECG 1103

Human  1104 LDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKD 1168
            ||||||||||||||||||||||||||||||||||||||.|.||||.|||||||||||||..||||
  Rat  1104 LDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGASCDLSSHCLSAPSSMTQDLPATPGKD 1168

Human  1169 QLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGRYRSQSGEDESMNQPGPIKTRLAISQSH 1233
            .||:|.||.||.||||.|:||||||||||||||||||||:||||||||:||||||||..||||:|
  Rat  1169 PLFTQHPVFRTPSQEGSQDLTQEQRDQLRADISIIKGRYQSQSGEDESLNQPGPIKTSFAISQAH 1233

Human  1234 LMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA 1283
            |||||.||||||:||:.|.||||||:|||||:|||||||:||.|||||||
  Rat  1234 LMTALAHTRPSINEDEGKEFAELYENFQNPKKRKNQSGTVFRTGQKVTLA 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	69/80 (86%)
		PEX-1N	104..179	CDD:462729	66/74 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		12/20 (60%)
		CDC48	<595..1065	CDD:273521	419/469 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283		19/22 (86%)
Pex1	NP_001102690.1	PEX-2N	17..98	CDD:462730	69/80 (86%)
		PEX-1N	104..179	CDD:462729	66/74 (89%)
		NACHT	418..>750	CDD:444362	266/332 (80%)
		CDC48	<595..1060	CDD:273521	416/464 (90%)