Protein Alignment PEX1 and CG16789

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 149/782 - (19%)
• Similarity: 283/782 - (36%)
• Gaps: 195/782 - (24%)

Human   351 NVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIP 415
            |::.|:|.:.:.:.||              ||:.:||     ||.:.:   .|::::...   ..
  Fly    80 NMIQPQKRQLVRKLLD--------------ACLGRVV-----ELKHDL---VNIDLMEFS---YN 119

Human   416 DDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLP-KDISEEDIKTVFYSWLQQSTTTMLP 479
            |::.:||        |:||:|...:|||....:.::.|. :..:..:|.|.. .||::...
  Fly   120 DEVVERL--------RLTPMETELRIPRYFLRERQQELEFRKKTMHEILTKL-GWLEEHEL---- 171

Human   480 LVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEI 544
                 ||.:..|.:      ::.::...|:.:...   |..:.:::  |::|.:....||.:|
  Fly   172 -----EETVTTEIE------AIRMLQMHERARQGR---LRAHFMKE--IRILKEKGKSEERTE-- 218

Human   545 DFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSR----QLMSLVAGLRNGALLLTGGKGSGK 605
                   |..|..|:  |....::.:......|.::|    :.|.|:                |.
  Fly   219 -------KERSDSGL--LAAMKIQKMWRGHTARRITRRRKMEEMILI----------------GM 258

Human   606 STLAKAICKEAFDKLD--AHVE-RVDCKALRGKRLENIQKTL--EVAFSEAVWMQPSVV------ 659
            .....|:.||..:||:  .|.| |...:|..||..|..|..|  |:.......|:..:.
  Fly   259 LPPPPAVVKERAEKLEKLQHNEKRYQAQAFYGKEFEERQNALKEEIRAKHGASMKEDIADEIRAW 323

Human   660 LLDDLDLIAGLPAVP----------------EHEHSPDAVQSQRLAHALNDMIKEFISMGSLVAL 708
            :.|..|....||..|                |.|||..:.:|.:.:....|..|.....|.|  .
  Fly   324 VKDCYDKTGKLPDFPSEDQGGSLHIFSRPGTESEHSRSSARSSKESRKTKDKSKSPARSGDL--N 386

Human   709 IATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDI------------ 761
            :..:|.::      ||      ||....:..|:.....::..:..::|.:..:
  Fly   387 VNENQDEE------VS------FQPAPSVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMIYS 439

Human   762 NKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTR---------------------- 804
            :|:.:::|:.  :.....|.|....|:..|:..::.:.|..||
  Fly   440 DKYQEVELEF--RRAVDDVMRQEIELLQTAVGKKVKKSSKKTRRSGKKSKKKKEKDLTPDRTTES 502

Human   805 --EKLVLTTLDFQK----ALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYP 863
              |:||...: .:|    .|:.||.....:..      :|.:...|  ::||||.:...||....
  Fly   503 LYEELVTNGI-IRKYPELRLKQFLGDKALTAR------IGTNPSPG--DIRQILTEYCILPLGSD 558

Human   864 ELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASE--QAVRDIF 926
            .:....|:.:  .|||.||.|:||..|...|..|.......:....::.||.|.|.  ..:..:.
  Fly   559 AIHNCTPLIR--SILLAGPKGSGKKALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIMLIHLVL 621

Human   927 IRAQAAKPCILFFDE----FESIAPRRGHDNTGVTD--RVVNQLLTQLDGVEGLQGVYVLAATSR 985
            ..::..:|.::|..:    |....|:     |..||  |:...|...:..:.....|..:..::.
  Fly   622 KVSRLLQPAVIFMGDAERPFMKKIPK-----TDRTDPKRLKKDLPKLIKNIAPEDRVVFIGTSNL 681

Human   986 PDLIDPALLRPGRLDKCVYCPPPDQVSRLEI-LNVLSDSLPLADDVDLQHVASVTDSFTGADLKA 1049
            |...|..||: ...::.:|.|.||..:.... ..:|.|......::|...:|.::|.:|...:.|
  Fly   682 PWEADQKLLQ-SVYNRFIYIPRPDYGAMSHAWKTLLHDYSGGISNLDTSAMAKISDGYTIGSIDA 745

Human  1050 LL 1051
            .|
  Fly   746 CL 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		4/15 (27%)
		CDC48	<595..1065	CDD:273521	104/533 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	43/223 (19%)
		SpoVK	443..773	CDD:440232	65/324 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	36/165 (22%)