Protein Alignment PEX1 and CG14183

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Alignment Length: 1081
• Identity: 184/1081 - (17%)
• Similarity: 370/1081 - (34%)
• Gaps: 305/1081 - (28%)

Human   120 ELHAVSLEQHLLDQIRIVFPKAI-FPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRR 183
            |:..:..:|:.|.:|.....||: :.::.:... :::::|..:....:...:...:.|::.....
  Fly    16 EIGKLIKKQNRLKKIEPPEEKAVSYKIYAELYV-LYVELVNKLSFIYHNTFQVQKRALVRVLVEN 79

Human   184 AKENTFS-KADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWT 247
            |.:.... |.:.:..::..|....|.::    .::|....:.:..|.:.....|:|..::.:
  Fly    80 ATQQLMQLKEELKDLEMSEYIYIDKALI----ARKLTPRDLVVWRSPQFLYRRPLDIQNIIA--- 137

Human   248 MIGSIFSFQSEKKQETS--WGLTEINAFKNMQSKVVPLDNIFRVC----KSQPPSIYNASATSVF 306
             ...::....||:::.:  |               ||:....::.    :::...:|.::.....
  Fly   138 -DNRLYMNDEEKEEKAAQDW---------------VPISEAVKLIQAHERARRARVYKSNIKYDK 186

Human   307 HKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQS-KTKQNVLSPE--KEKQMSEPLDQK 368
            .|...:|      :...:...||         ..|.|..| ..|:.:.|.:  |..:..|.|.:|
  Fly   187 KKFLKVH------QRKKINYKFT---------FKPDQAMSIPVKRTIFSADFLKADESCENLIKK 236

Human   369 KIRSDHNEEDEK---------ACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNI 424
            ...:|...:||:         ||.:|..|.|       .|..|.|::            |||...
  Fly   237 DDVADTAIDDEEALSAIQNNAACKIQSCWRG-------YKTRKIVKI------------RKRFKE 282

Human   425 EMHAVVRITPVEVTPKIPRS-LKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFI 488
            |::.:.:|..::...:...| :::...|.|.|.:.|:     |.:.:....|.:|..   ...::
  Fly   283 ELYGMKKIRKLKRPNQTANSIMEMYKNEMLKKKLDED-----FINLINDERTRLLQF---RSPWM 339

Human   489 KLETKDGLKEFSLSIVHSWEKE--KDKNIFLLSPNLLQKTTIQVLLD----PMVKEENSEEIDFI 547
            ..:..|.::        :|.||  .....|...|:.:::.|:.|::|    ||..:|
  Fly   340 MEDISDHIR--------AWFKEFYDATGNFHPYPDPVKQGTVLVVIDETMTPMEFQE-------- 388

Human   548 LPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAI 612
                         |||            .:|||:..:..:.......      |...|..|.:..
  Fly   389 -------------SLG------------KKPLSKAELKKLRDKEKKE------KRKKKEKLKQLK 422

Human   613 CKEA--FDKL-DAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVP 674
            .|||  ..|| ||.|..:..:....|.:|||::|::
  Fly   423 MKEAKRRKKLRDAGVIDIGYELTASKAIENIEETMK----------------------------- 458

Human   675 EHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQP 739
              ::|.|........:..:|.|||:::...|..:      .|.:..|:.....|......:.:..
  Fly   459 --KYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKI------HQEVRGLVDEYMRVEYELLREALAK 515

Human   740 PNQEQRCEILCNVIKNKLDCDINKFTDL-------DLQHVAKETG-----------GFVARDFTV 786
            .|.|:...:.....|.|.:....|..|:       .|.:..|:.|           .|:. ||..
  Fly   516 DNDEKYKALKVKYPKKKKEKRKKKPKDMTGDRTLESLYNELKDAGIIEEIGHRDFDEFIT-DFNF 579

Human   787 LVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQI 851
            :.|            .||::..||||...|.                             :::.:
  Fly   580 VAD------------DTRDEDGLTTLGPAKG-----------------------------DIKMV 603

Human   852 LMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIG 916
            :.:::....::       .:.:...:||.||..:||.||..:||.|....|::: .||...||..
  Fly   604 IQESMLGMGEF-------DVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAK 660

Human   917 ASEQAVRDIFIRAQAAKPCILFFDE-----FESIAPRRGHDN-----TGVTDRVVNQLLTQLDGV 971
            ..:..:..|...|:|.:|.|::.:|     ::.:.|.....|     |.:..:::.. |.:.|.:
  Fly   661 DLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILKP-LKKNDKI 724

Human   972 EGLQGVYVLAATSR-PDLIDPALLRPGR----LDKCVYCPPPDQVSRLEILNVLSDSLPLADDVD 1031
                   ||..||. |...:..:.|..:    :.||.|     ..|.|..|.:::::.|
  Fly   725 -------VLVGTSNMPWAANGGIKRAFQKVLLIPKCDY-----GTSFLLWLELMTENAP------ 771

Human  1032 LQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDS 1096
                         .|:|...|:|....|...          :|.|.|.::...:.::......:.
  Fly   772 -------------DDMKEYAYSALARVLQAY----------NSGDIDDNVKETLNIDRKMRLKNE 813

Human  1097 AGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESE 1137
            |.|....|:..|...|.....|||...:.:..:||||.:.|
  Fly   814 ALDPNEFLEYFLSKNEPPIFPPDEKIMDKFNKWFGSSNKLE 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729	8/59 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		6/23 (26%)
		CDC48	<595..1065	CDD:273521	91/505 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283
CG14183	NP_649172.3	Adgb_C_mid-like	<201..>278	CDD:412094	22/104 (21%)
		globin helix H	201..232	CDD:412094	8/39 (21%)
		IQCD	247..278	CDD:467745	9/49 (18%)
		IQ motif	259..277	CDD:412094	7/36 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	617..750	CDD:476819	33/141 (23%)