Protein Alignment PEX1 and CG5776

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Alignment Length: 845
• Identity: 230/845 - (27%)
• Similarity: 397/845 - (46%)
• Gaps: 133/845 - (15%)

Human   257 SEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEY 321
            |.||.:.:|...| :...::.||.  .||...:|.:.........:.:.:.:..||:.....|..
  Fly     6 SSKKNQVTWYHCE-SCGVHIPSKA--RDNHEGLCFAISQDDVGPDSEAEYVRSGAIYTRSLQQRN 67

Human   322 FDVE--PSFTVTYGKLVKLLSP---KQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKA 381
            |:||  ......|..::..:|.   :..|....|:|:. |......:||
  Fly    68 FEVESLKDLPTKYANMLVFVSEGAMQLAQLHIGQHVVL-EAPSTAEQPL---------------- 115

Human   382 CVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRL---------NIEMHAVVRITPVEV 437
              :::||...|:....:..::....||.      ..||.:|         .:...|.:.:..|..
  Fly   116 --VRIVWPTSEQFLTTVFVSEGDFKLHC------TQLRGKLLKISALHPSRLTAAASISLKHVNT 172

Human   438 TPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGL---KEF 499
            |....:|::||....|   :..:.:..|||                         ||.|   ..|
  Fly   173 TETSLKSVQLQDAIAL---LKRDMVNRVFY-------------------------KDSLIHMNFF 209

Human   500 SLSI---VHSWEKEKDKNIFLLSPN--------LLQKTTIQVLLDPMVKEENSEEIDFILPFLKL 553
            :.|:   :..|:...::.:..||.:        :...|.:.::.|...::|..::|...:...::
  Fly   210 NKSLTFRLERWQSTVEEALAGLSLDSKPLQFIQVTNVTKLHLITDDANQQEEEQKISHRITKCQI 274

Human   554 SSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLR-NGALLLTGGKGSGKSTLAKAICKEAF 617
            ..|.....|...|:|:    .||      ..:|.|||| :..|||.|..|.|||.:.:|:|..|.
  Fly   275 GGLDRQLQLVEESMEY----ALG------FRTLPAGLRVSRGLLLYGATGCGKSMVLEAMCAVAE 329

Human   618 DKLDAHVE--RVDCKALRGKRLENIQKTLEVAFSEAV--WMQPSVVLLDDLDLIAGLPAVPEHEH 678
            ::...||:  |::...:..|.|...::.|...|..|.  :..|:::|::|:..:.     |:.|:
  Fly   330 ERSQGHVQLIRINSGEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLC-----PKQEN 389

Human   679 SPDAVQSQRLAHALNDMIKEFIS----MGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQP 739
            | |.|  :|::.|...::.:..|    .||...::|||....:|||   |.:..........:..
  Fly   390 S-DLV--KRVSLAFLSLLDQLSSPSQLKGSKTFVLATSSQIDTLHP---SIRRAGRLDNEVELGA 448

Human   740 PNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTR 804
            |:.:.|.||:..:||:.    .::.:|.:::|||..|.|:|..|...||..|:   |..|.
  Fly   449 PSSQARLEIVRCLIKSV----EHQLSDEEVEHVASITHGYVGADLANLVYAAM---LQAQP---- 502

Human   805 EKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANL 869
            ..|.:..|  |.||....|:::|.|.:..| ::.|..|||..|:|..:...|:.|..:.:.|..|
  Fly   503 NPLQMPHL--QAALTRIKPSAMREVLIECP-NVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRL 564

Human   870 PIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKP 934
            .|:...|||::||||..||::|..:|.||::||:|:|||||.|.::|.||:|||::|.:|:...|
  Fly   565 GIKPPRGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAP 629

Human   935 CILFFDEFESIAPRRGH-----DNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALL 994
            .|:||||.::|...|..     ..:.|.:||:.||||:|||||.||.|.::|||:|||:||.|||
  Fly   630 AIVFFDEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALL 694

Human   995 RPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
            ||||:|:.:|...|...:|.|||.:...::|:::|||::.:..:|:.::||:::|:.:.|.|.||
  Fly   695 RPGRIDRILYVGLPQCEARREILKIKLRAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAALRAL 759

Human  1060  1059
              Fly   760  759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		5/20 (25%)
		CDC48	<595..1065	CDD:273521	165/478 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	193/640 (30%)