Protein Alignment PEX1 and pex1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_587770.1
• Gene: pex1 / 2539405
• PomBaseID: SPCC553.03
• Length: 937
• Species: Schizosaccharomyces pombe
• Alignment Length: 1193
• Identity: 306/1193 - (25%)
• Similarity: 494/1193 - (41%)
• Gaps: 326/1193 - (27%)

Human    19 VAFTNARDCFLHLPRRLVAQL-HLLQNQAIEVVWSH---QPAFLSWVEG--RHFSDQGENVAEIN 77
            |::.:.|.|.:::|..|:..: ..:||.|::.|...   :..|...:.|  ..||      .||:
pombe     5 VSYKSLRSCLVNVPELLLESISEPVQNYAVQAVVCKNDIKKTFYFGISGIPSQFS------FEID 63

Human    78 RQVGQKLGLSNGGQVFLK--PCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPK 140
            ......|.|:...::.|.  .|:|.:  :|:|:||::::||||.|.:|..||::||.|.|:...:
pombe    64 STYAHTLKLAENQEINLSIIDCTHEI--EQLEIEPVTSNDWEIAERNAAWLEENLLVQYRVATTE 126

Human   141 AIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRD 205
            . |.:::...|:|..|.:.|||::..|||...|::||.|     |.||.:....|.:|:
pombe   127 R-FIIYLPSGTFIQFQPLKLIPSSLCGRLLRTTEVLITP-----KPNTSAIEVKENRKV------ 179

Human   206 QKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKKQETSWGLTEI 270
                           |...:.|:......:..||.::.        :|
pombe   180 ---------------NLRCVVENRLLPDSVTADSPALC--------VF----------------- 204

Human   271 NAFKNMQSKVVPLDNIFRVCKSQPPSIY----NASATSVFHKHCAIHVFPWD-QEYFDVEPSFTV 330
                      :||:     ...:|..:|    |..:|.|    |.....|:. ..:|.:..|..:
pombe   205 ----------LPLN-----FPDRPDVVYMDGGNLKSTIV----CQCVSCPFQIPGHFFISKSLAL 250

Human   331 TYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELN 395
            :|                                                            .:.
pombe   251 SY------------------------------------------------------------SIK 255

Human   396 NAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEE 460
            ...|:          ::|           :.|     .|...:..|.....|.|..||..::...
pombe   256 TGFKF----------QIW-----------KAH-----NPPSSSKFILEQKGLPPESNLSSELVAA 294

Human   461 DIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQK 525
            .:|.   |:|....|              |:..|....:|:|.:....|...::|.:.|     .
pombe   295 KLKN---SYLMDGMT--------------LKLVDIAVSYSVSGLSGVVKNPIQDIKITS-----D 337

Human   526 TTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGL 590
            |.:.|                        :.|..|:....|::...|..             |.:
pombe   338 TNVPV------------------------NAGIRNNSPRLSMQPFPHEF-------------AQV 365

Human   591 RNGALL-----LTGGKGSGKSTLAKAICKEAFD--KLDAHVER--VDCKALRGKRLENIQKTLEV 646
            ||...|     :.|.||.|||.|..::    ||  .|::...:  |.|..:........|.....
pombe   366 RNAVFLHQNIYINGPKGCGKSNLVHSL----FDYYSLNSIYFQMIVSCSEIDRSSFAKFQSFWNN 426

Human   647 AFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSP-DAVQSQRLAHALNDMI-------------- 696
            .|.:|...:||::.|||:..:..    ..:|:.. ..|:.:.:|...:.:|
pombe   427 VFIQAERYEPSIIYLDDVHCLIS----SSNENGELGFVEEREIAFLQHQIINLKRKRKIIFIGFG 487

Human   697 KEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDI 761
            :||::....:.|....|.:.:|..|.|:                   :|.|||..:.:
pombe   488 EEFLTFSENLVLPLLFQIKIALPSLAVT-------------------RRKEILTTIFQ------- 526

Human   762 NKFTDL---DLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLP 823
            ..|:|:   .::.::.:|.|::..|..:.|.|.: |....:.|....|.::.....:|.|:.|:|
pombe   527 ENFSDITMDSIEFISVKTEGYLMTDLVLFVKRLL-SEAFVEKIQNGPKHLMNKGLIEKTLKDFVP 590

Human   824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKT 888
            ..||.....| ..:.|..|.|:.|.::.:.|.|:.|.||..::....:|..|||||:|.||.|||
pombe   591 LQLRKAKFVK-SSIRWIDIAGMQEAKEAVRDIIESPVKYSLIYKQCRLRLPTGILLFGYPGCGKT 654

Human   889 LLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDN 953
            .||..|:....:.|||:||||||.||||.|||.|||:|.|||.||||:||||||:|:|||||.|:
pombe   655 YLASAISSTFPVQFISIKGPELLDKYIGKSEQGVRDLFSRAQMAKPCVLFFDEFDSVAPRRGQDS 719

Human   954 TGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILN 1018
            ||||||||||:|||:||.|.|.|||::|||:|||:|||||||||||||.::|..|::..|||:|.
pombe   720 TGVTDRVVNQILTQMDGAESLDGVYIVAATTRPDMIDPALLRPGRLDKLIFCDLPNEEERLEVLQ 784

Human  1019 VLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGML--LSSGLQDGSSSSDSDLSL 1081
            .|::...:.:...|:.::::||.:|.|||.:|||:|.|.|:|.:|  :|....|.|.::.|..:|
pombe   785 KLANRFHIENAAMLKKLSTLTDGYTYADLSSLLYDAHLIAVHKLLKRVSINAVDPSQTTSSFTNL 849

Human  1082 -------SSMVFL--------NHSSGSDDSAGDGEC-----GLDQSLVSLEMSEILPDESKFNMY 1126
                   :||:.|        |..|.||..:...|.     .|.::..||...|.   |...|:|
pombe   850 TTESKRNASMLALPPESRYNQNMQSMSDSKSVVIEDYMLMEALKKNSPSLNSEEF---EHLSNLY 911

Human  1127 RLYFGSSYESELGNGTSSDLSSQ 1149
            |.:....:|.|| |..::|:.|:
pombe   912 RDFRSKLFEPEL-NARNTDVGSK 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	18/86 (21%)
		PEX-1N	104..179	CDD:462729	29/74 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		0/20 (0%)
		CDC48	<595..1065	CDD:273521	178/498 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283
pex1	NP_587770.1	PEX-1N	90..164	CDD:462729	29/74 (39%)
		CDC48	<373..915	CDD:273521	198/580 (34%)
		RecA-like_PEX1_r2	614..771	CDD:410934	99/156 (63%)