Protein Alignment PEX1 and prx-1

DIOPT Version :10

• Sequence 1: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_510386.2
• Gene: prx-1 / 181538
• WormBaseID: WBGene00004191
• Length: 996
• Species: Caenorhabditis elegans
• Alignment Length: 1105
• Identity: 299/1105 - (27%)
• Similarity: 478/1105 - (43%)
• Gaps: 261/1105 - (23%)

Human    76 INRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPK 140
            ||....:..|.....:|.|:.......|..:||.|.:.||:.::.....|:|...|:|||:|...
 Worm    75 INSVFAEVSGFHEKQEVILEKMESKTYCSHIEVAPRTEDDYSVIAQSQSSIENEFLNQIRLVSQN 139

Human   141 AIFPVWVDQQTYIFIQIVALIPAASYG-RLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGR 204
            .|.|.::....|:..:|:.::||::.. .|..||:|.:|..|..::.:  .||....|
 Worm   140 MIIPHFLSPGVYVQFRILNIVPASNKPVMLNNDTELHVQTVTEGSQND--EKATMAQK------- 195

Human   205 DQKGMMKELQTKQLQSNTVGITESNENESEIPVDS----SSVASLWTMIG-------SIFSFQSE 258
             ...::::|..:...||.|      .|..:.|:..    .....||...|       :|:....|
 Worm   196 -VSNIVQDLSMQGFLSNYV------INLEKTPIIGRVLPKKTVELWVKSGLEKLDKSTIYIPGKE 253

Human   259 KKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIY--------NASATSVFHK------- 308
            ....:..|:.||.:....:::  .....|.:.:|  |:||        :||.:.:|..
 Worm   254 SCLYSEHGIVEIRSQGRGENE--ERFQFFYLHRS--PNIYLRNQSNELDASLSHMFESLQLENRC 314

Human   309 HCAIHVFPWDQEYFDVEPSFTVTYGKLVKL-LSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRS 372
            || :......:.|.::: .|.||..::..| ......:.:|.|.|    ||.:::..|    .:|
 Worm   315 HC-VEGTNTLEPYMNIK-IFGVTQNRICTLRYCEIMMEKETFQWV----KEFELTNVL----TKS 369

Human   373 DHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEV 437
            .|:|......:|.|  .| :||:.|:                 ||...||
 Worm   370 LHSELQGNPILLSV--EG-KELDVAV-----------------DDKAIRL--------------- 399

Human   438 TPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLS 502
              |:..|:|     .|.|.::|   .|.|   |...||.::     .::...|:.|.|..|
 Worm   400 --KVVPSMK-----GLVKRVTE---NTCF---LFDLTTELI-----FQQLGDLKQKHGDTE---- 442

Human   503 IVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSL 567
                            :....:|.|.:.        |.||:|.      :......:.:.|.:..
 Worm   443 ----------------NTRRRRKRTEEA--------EASEQIP------QKPETSTMENFGFAQN 477

Human   568 EHI----THSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKE-------AFDKLD 621
            :|.    :||.|   || :|..:..|.:...::| ||.||||:|..|.:.:.       .|.|:
 Worm   478 KHFVQIGSHSKL---LS-ELDKVCCGGKQHVMVL-GGNGSGKTTFIKKLARRLSHNSSVTFCKM- 536

Human   622 AHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQ 686
                 |.|..|:|:..:.|:|.|.....|....:||.:.|||.|:|  ||.:.         |.|
 Worm   537 -----VPCALLKGRSADIIEKLLSDTLHEMEVKKPSCLFLDDFDVI--LPQID---------QEQ 585

Human   687 RLAH-ALNDMIKEFIS--MGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQ---HIQPPNQEQR 745
            |  | |:..::..|..  ..:.|:::..:|...||:...|. |.:.....|.   .::...:|.|
 Worm   586 R--HLAMEKVVSVFAQKLRTTEVSVVLVAQRLSSLNDGFVE-QVMRARPIVSRKIELEQLTKEDR 647

Human   746 CEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLV-- 808
            |||....:      |:.:.:|: :..:.|::.|:.            .|.:.:.::|...:..
 Worm   648 CEIFETFL------DLPENSDI-ISEIVKKSDGYT------------FSEIEKLAVSINVECAIK 693

Human   809 ----LTTLDFQKALRGFLPASLRSVN----LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPEL 865
                :|.::.:||...|:...:..:.    |....|     :||:.|.:::|...|..|.|||:|
 Worm   694 GVKYITEIEVEKAFECFVAGKMGKIEDGQVLPTMED-----VGGMFEQKKLLEQVIIWPRKYPQL 753

Human   866 FANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQ 930
            |.::.:....||||:||.|.||||||......|..:.::|||||||||||||||:.||.:|.:|:
 Worm   754 FESVGVPVSKGILLHGPSGCGKTLLANATISNSNFSVVNVKGPELLSKYIGASEENVRLVFEKAR 818

Human   931 AAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVE-GLQGVYVLAATSRPDLIDPALL 994
            :..||||||||.:|:||:||||:|||||||||||||:|||.| |::||.:|..|||.||||.|||
 Worm   819 SCAPCILFFDELDSLAPKRGHDSTGVTDRVVNQLLTELDGAEGGMKGVIILGCTSRIDLIDDALL 883

Human   995 RPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
            ||||.|..|||..|::..||:|:.||::.|. ..|||.:.:|..||.::||||:.|..|||
 Worm   884 RPGRFDHHVYCGHPEKTERLDIMKVLTNKLK-PTDVDFECLAQKTDGWSGADLQLLFTNAQ---- 943

Human  1060 HGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFN 1124
                                      |.|....:.:     |.||::..|.::.:.|   ||.||
 Worm   944 --------------------------FYNARQIAKE-----EDGLEEDNVPIDQASI---ESVFN 974

Human  1125  1124
             Worm   975  974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730	5/21 (24%)
		PEX-1N	104..179	CDD:462729	22/75 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		6/20 (30%)
		CDC48	<595..1065	CDD:273521	177/493 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283
prx-1	NP_510386.2	PEX-1N	103..179	CDD:462729	22/75 (29%)
		P-loop containing Nucleoside Triphosphate Hydrolases	481..>522	CDD:476819	16/45 (36%)
		CDC48	<504..952	CDD:273521	179/523 (34%)
		RecA-like_PEX1_r2	736..894	CDD:410934	93/157 (59%)