DRSC/TRiP Functional Genomics Resources

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Protein Alignment PER1 and per

DIOPT Version :10

Sequence 1:NP_002607.2 Gene:PER1 / 5187 HGNCID:8845 Length:1290 Species:Homo sapiens
Sequence 2:NP_525056.2 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster


Alignment Length:1394 Identity:286/1394 - (20%)
Similarity:442/1394 - (31%) Gaps:476/1394 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    41 LADDTDANS--------NGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQS 97
            ::|...:||        :|||.:..:|..|.|:|......|:..:..|..:....:.|:......
  Fly    15 VSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNK 79

Human    98 PSPPSSSIAYSLLSASS-------EQDNPSTSGCSSEQSARARTQKELM-----------TALRE 144
            .:...:..|.:|:|||:       |:..||.:||..:|..|     ||.           .|:.:
  Fly    80 GAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICR-----ELQDQQHGEDHSEPQAIEQ 139

Human   145 LKLR-------------------------------------LPPERRGKGRSGTLATLQYALACV 172
            |:..                                     :||...|.|..|..|.|...||  
  Fly   140 LQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLA-- 202

Human   173 KQVQANQEYYQQWSLEEGEPCSMD----MSTYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVY 233
                   ::.:.|....|:..||.    .:..|.:..|.:       .:|:|...:|...|.::|
  Fly   203 -------KFDKTWEAGPGKLESMTGVGAAAAGTGQRGERV-------KEDSFCCVISMHDGIVLY 253

Human   234 ISEQAAVLLRCKRDVFRGTRFSELLAPQDVGVFYGSTAPSRLPTWGTGASAGSGLRDFTQEKSVF 298
            .:.....:|...||::.|..|.:.:..:|...| .|...:.:|   ...|.||..:|   .||.|
  Fly   254 TTPSITDVLGYPRDMWLGRSFIDFVHLKDRATF-ASQITTGIP---IAESRGSVPKD---AKSTF 311

Human   299 C----RIRGGPDRDPG-----PRYQPFRL------TPYVTK---IRVSDGAPAQPCCLLIAERIH 345
            |    |.||......|     ..|:||||      .|...:   ..||:|  .....::.|..|.
  Fly   312 CVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNG--TNMLLVICATPIK 374

Human   346 SGYEAP------RIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPL 404
            |.|:.|      :.|.    |..|||.:.:...||..|...||||||||:|..::.|.|.||..:
  Fly   375 SSYKVPDEILSQKSPK----FAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSV 435

Human   405 MLAIHKKIL---QLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSRKVAFVLGRHKVRTAPL 466
            |...::.::   |.||..|...|.||..:||.||.::|.|..||:|||||:.||:|.|:|...|.
  Fly   436 MKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPK 500

Human   467 NEDVFTPPAPSPAPSLDTDIQE--------LSEQIHRLLLQPVHSPSPTGLCGVGAVTSPGPLHS 523
            ..:||     ..||:....|.|        :.|.|.:.|.:.|..||.|                
  Fly   501 QCNVF-----EAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDT---------------- 544

Human   524 PGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIESRARPQSRPRLPATGTFKAKAL 588
                                 ..|::.:     :.|....|:|:.....||..|..       .|
  Fly   545 ---------------------VKQEVSR-----RCQALASFMETLMDEVSRADLKL-------EL 576

Human   589 PCQSPDPELEAGSAPVQAPLALVPEEAERKEASSC----SYQQINCLDSILRYLESCNL------ 643
            |.::   ||............:.|........||.    ||.|:|..:::||:..|..:      
  Fly   577 PHEN---ELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAEL 638

Human   644 ------PSTTKRKC------------------ASSSSYTT------SSASDDDRQRTGPVSVGTK 678
                  |...:..|                  .||.::||      ||.::.....||....||.
  Fly   639 DPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTG 703

Human   679 KDPPSAALSGEGATPRKEPVVG---GTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESD 740
            ....:...:|.|.........|   ||.:.....|...|                          
  Fly   704 TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNS-------------------------- 742

Human   741 IIMMEDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRLR 805
                    |...|.|.|........|        ||.||:::|:.|..:.|:..|.:.|:.....
  Fly   743 --------GTGTGTASSSKGGSAAIP--------PVTLTESLLNKHNDEMEKFMLKKHRESRGRT 791

Human   806 GLDSSSTAPSALGERGCHHGPAPPSRR---HHCRSKAKRSRHHQN-------------------- 847
            |..|..:|...| :...:.||....:|   |....:|.:.:....                    
  Fly   792 GEKSKKSANDTL-KMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTG 855

Human   848 ------------------------------------------------PRAEAPCYVSHPSPVPP 864
                                                            ..|.|...|...:|.|.
  Fly   856 GVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPS 920

Human   865 STP--------WP------TPPATTPFPAVVQ---------------PYPL----PVFSPR---- 892
            |.|        ||      |||..:...|:.|               |..|    |..|||    
  Fly   921 SYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKH 985

Human   893 ---GGPQPLPPAPTSVPPAAFPAPLVTPMVALVLPNYLFPTPSSYPYGALQTPAEGPPTPASHSP 954
               ||..    .||:...||..|....|:  ..:...::|.||.:    ...||....|...:.|
  Fly   986 PHKGGTD----MPTTSQQAAAAAAQAMPL--QYMAGVMYPHPSLF----YTHPAAAAATAMMYQP 1040

Human   955 SPSLPALAPSPPHRPDSPL-------------------------FNSRCSSPLQLNLLQLEELPR 994
            .| .|.:| :....|:.||                         |:| .::|.|:      :.|.
  Fly  1041 MP-FPGMA-NALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHS-VTTPAQV------QRPS 1096

Human   995 AEGAAVAGGPGSSAGPPPPSAEAAEPEARLAEVTESSNQDALSGSSDLLELLLQEDSRSGTGSAA 1059
            ::.|:|...|||||....|..:.....:.:..|....|.|....||:      ..:::..|.|  
  Fly  1097 SQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSN------PANNKKYTDS-- 1153

Human  1060 SGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSIDSSEAEAGAARGGAEPGDQVIKY 1124
                       :|:.....|        ||.||..|.:..:.|.||:.....:   :|..:.:| 
  Fly  1154 -----------NGNSDDMDG--------SSFSSFYSSFIKTTDGSESPPDTEK---DPKHRKLK- 1195

Human  1125 VLQDPIWLLMANADQRVMMTYQVPSRDMT 1153
                    .|:.::.::|   :.|..|.|
  Fly  1196 --------SMSTSESKIM---EHPEEDQT 1213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PER1NP_002607.2 Interaction with BTRC. /evidence=ECO:0000269|PubMed:15917222 1..151 29/172 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..134 25/107 (23%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:O54943 138..147 3/19 (16%)
PAS_3 373..457 CDD:430001 39/86 (45%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:O35973 489..498 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..544 0/35 (0%)
Required for phosphorylation by CSNK1E. /evidence=ECO:0000250 596..815 48/261 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..698 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 749..772 5/22 (23%)
PHA03247 <765..1025 CDD:223021 73/395 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..874 21/153 (14%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O35973 827..843 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 938..977 11/63 (17%)
Nuclear export signal 3. /evidence=ECO:0000250|UniProtKB:O54943 982..989 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 996..1037 11/40 (28%)
LXXLL 1043..1047 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1051..1098 9/46 (20%)
Period_C <1083..1202 CDD:463464 15/71 (21%)
CRY binding domain. /evidence=ECO:0000250 1149..1290 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1207..1290
perNP_525056.2 PAS 238..333 CDD:395786 26/101 (26%)
PAS 388..495 CDD:238075 46/110 (42%)
Blue background indicates that the domain is not in the aligned region.

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