Protein Alignment ADA2 and Adgf-A2

DIOPT Version :10

• Sequence 1: NP_001269154.1
• Gene: ADA2 / 51816
• HGNCID: 1839
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_525020.2
• Gene: Adgf-A2 / 64879
• FlyBaseID: FBgn0043025
• Length: 561
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 167/521 - (32%)
• Similarity: 281/521 - (53%)
• Gaps: 43/521 - (8%)

Human    12 LCFLLLAVAMSF-FG---SALSIDETRAHL----LLKEKMMRLGGRLVLNTKEELANERLMTLKI 68
            ||.::|.:..|. .|   |.|:.:|..|.|    :.||:..|||.|:.|:..||.||:|||.::
  Fly    54 LCVMVLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIR- 117

Human    69 AEMKEAMRTL-----IFPPSMHFFQAKHL-IERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRN 127
             ::.|....|     ..||..    .||| |..:.::..|:.||||..||:||.|::.|:.|: :
  Fly   118 -QVDEEFYNLWRNYHSQPPPF----LKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILI-D 176

Human   128 VTYRPHCHICFT-PRGIMQFRFA----HPTPRPSEKCSKWILLEDYRKRVQNVTEFDDSLLRNFT 187
            :.||.:..:|.. .:....|||:    |..|....:|: |:|:.:: .::::..||::.|.:..|
  Fly   177 LIYRDNLWVCVNLEQDFEDFRFSRYFPHIPPAEDYQCN-WMLMSNF-FQLESRLEFENRLRKTLT 239

Human   188 LVTQHPEVIYTNQNVV--WSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNVLYMEIRARLL 250
            :   .||...::..:.  ..:.:.|   |.|||.:.|::.:::|..:.:||.|.|.|:|:|:.|.
  Fly   240 V---RPEGYKSSSELARHLRRHQRI---IHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLP 298

Human   251 PVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKF 315
            .:|:|.|.:.....:.:....|:..|..:..:|||||:||:..|:.:.:.:.|.:..|..|::.|
  Fly   299 NMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLHF 363

Human   316 PTVVAGFDL--VGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDWQGTS-IDRNILDALML 377
            |...|||||  .|.|.....|.:..:.|.|    |..:.::|||||:....:| .|.|:|:||:|
  Fly   364 PNFFAGFDLNTFGDECNLPLLENVTQLLRI----GKNIDFYFHAGESRCPDSSRPDANLLEALLL 424

Human   378 NTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHPMVISSDD 442
            .:.|||:...|..||.:.....:..|.:|:||:||..|:..:|.|.||.|.|:|.|.|:||.||.
  Fly   425 QSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDY 489

Human   443 PAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNTFMEIWKKRWDKFIAD 507
            |..:.:..|:.|||..|:|:.....|||.|||.|:||..:|:|.|:|||..:..|:..|::::.:
  Fly   490 PCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQCSWNRWVRN 554

Human   508 V 508
            :
  Fly   555 L 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADA2	NP_001269154.1	adm_rel	30..509	CDD:273620	160/499 (32%)
		Dimerization	30..100		25/79 (32%)
		PRB domain	127..185		14/62 (23%)
Adgf-A2	NP_525020.2	A_deaminase_N	59..152	CDD:462481	30/98 (31%)
		ADGF	135..548	CDD:238646	139/429 (32%)