Protein Alignment ADA2 and Adgf-A

DIOPT Version :10

• Sequence 1: NP_001269154.1
• Gene: ADA2 / 51816
• HGNCID: 1839
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_524130.1
• Gene: Adgf-A / 39976
• FlyBaseID: FBgn0036752
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 471
• Identity: 193/471 - (40%)
• Similarity: 281/471 - (59%)
• Gaps: 12/471 - (2%)

Human    41 EKMMRLGGRLVLNTKEELANERLMTLKIAEMKEAMRT-LIFPPSMHFFQAKHLIERSQVFNILRM 104
            |:...||..|.||::|..|||.:|..|:.|..|.:.| .:|.||.|.|.....|..:.:|.:|:.
  Fly    77 EESRSLGHDLDLNSREIKANETIMKAKLKEFDEGLVTPHLFKPSQHIFDVLDGIRNTDLFKLLKK 141

Human   105 MPKGAALHLHDIGIVTMDWLVRNVTYRPHCHICFTPRGI--MQFRFAHPTPRPSEKCSKWILLED 167
            |||||.||.||..:.:...:: |:||..|...|.....:  ...||:...|:....|. |.||.|
  Fly   142 MPKGAVLHAHDTALCSTAAII-NLTYYEHLWSCQQDGDLSASALRFSKDKPQALSDCD-WSLLSD 204

Human   168 YRKRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSM 232
            .|.: ....:.||.|....||   :|...:.:.|..||.|.:||..:.||:.||||:.||.::::
  Fly   205 VRAK-YGADKVDDYLAERLTL---YPTKKFEDNNAAWSTFMSIFNLLDGLVMYAPVWADYYYKAL 265

Human   233 QEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKD 297
            :|||||.|||:|.|:.:..:|::.|.......:|:.|.|..:||.|.||:|||.::||:..|..:
  Fly   266 EEFYEDGVLYLEFRSVVPTLYDMDGTEFTPMDTVRIYVETLEKFKEAHPDFIGSRMIYAPIRYTN 330

Human   298 VAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDW 362
            ...:...|:....::.|:|..||||||||.|:.|..|.|:.:.|:....|   :.::||||||:|
  Fly   331 AEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEMGRPLRDFVDELLSIPDD---IDFYFHAGETNW 392

Human   363 QGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVA 427
            .|:::|.|::||::|.|.||||||.|.|||.|.....|.::.|||.|||||||:||||.||||.:
  Fly   393 FGSTVDENLIDAILLGTKRIGHGFGLVKHPVVLDMLKKLNVAIEVNPISNQVLQLVSDFRNHPCS 457

Human   428 TLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNT 492
            ...|.|:|:|||||||:.:.|..|::|||..|:||....:|||.||:||:|||:||:|....:..
  Fly   458 HFFADGYPVVISSDDPSFWKATPLTHDFYIAFLGIASQHSDLRLLKKLALNSIQYSSLTGDAQFE 522

Human   493 FMEIWKKRWDKFIADV 508
            .:|.|:.:||:|||||
  Fly   523 ALEKWQVKWDQFIADV 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADA2	NP_001269154.1	adm_rel	30..509	CDD:273620	193/471 (41%)
		Dimerization	30..100		21/59 (36%)
		PRB domain	127..185		17/59 (29%)
Adgf-A	NP_524130.1	adm_rel	66..538	CDD:273620	191/469 (41%)