Protein Alignment ADA2 and AMPdeam

DIOPT Version :10

• Sequence 1: NP_001269154.1
• Gene: ADA2 / 51816
• HGNCID: 1839
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_001285233.1
• Gene: AMPdeam / 32352
• FlyBaseID: FBgn0052626
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 107/587 - (18%)
• Similarity: 188/587 - (32%)
• Gaps: 222/587 - (37%)

Human     1 MLVDGPSERPALCFLLLAVAMSFFGSALSIDETR-------------------------AHLLLK 40
            |:.|||.:  :.|:..|....|.:...:.::|.|                         |..:.:
  Fly   294 MIADGPLK--SFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQ 356

Human    41 EKMMRLGGRLVLNTKEE---LANERLMTLKIAEMKEAMRTLIFPPSMHFFQA---KHLIERSQVF 99
            :.::|...:.:.|...|   :.|.:.|||  |::.::|....:..::.....   ::...|...|
  Fly   357 KHLLRFIKKTLKNNANEVVTVTNGQQMTL--AQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKF 419

Human   100 NILRMMPKGAALHLHDIGIVTMDWL--------VRNVTYRPHCHICFTPRGIMQFRFAHPTPR-- 154
            | .:..|.|.: .|.::.:.|.::|        ::.|.:           .:.:.::.:...|
  Fly   420 N-SKYNPIGES-RLREVFLKTDNYLNGKYFAQIIKEVAF-----------DLEESKYQNAELRLS 471

Human   155 -----PSE--KCSKWILLEDYRKRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFF 212
                 |.|  |.:||.:..|                            :|:: |:.|
  Fly   472 IYGKSPDEWYKLAKWAIDND----------------------------VYSS-NIRW-------- 499

Human   213 TISGLIHYAPVFRDYVFRS---MQEFYE--DNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEV 272
                ||....:|.  :|:|   |:.|.|  :|:        .||::|.:..
  Fly   500 ----LIQIPRLFD--IFKSNKMMKSFQEILNNI--------FLPLFEATAR-------------- 536

Human   273 AQKFVETHPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHS-LHD 336
                ...|||.         ||                    |...|.|||.|..|....: |.|
  Fly   537 ----PSKHPEL---------HR--------------------FLQYVIGFDSVDDESKPENPLFD 568

Human   337 ----------YKE----ALMIPAKDGVKLPYFFHAGETDWQGTSIDRNI---------------- 371
                      |:|    |..|         |:.:|..|........||:
  Fly   569 NDVPRPEEWTYEENPPYAYYI---------YYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQ 624

Human   372 -LDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHP 435
             |....|....|.||..|.|.|.::...:...|.|.:.|:||..|.|  :...:|:...:|.|..
  Fly   625 HLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFL--NYHRNPLPEYLARGLI 687

Human   436 MVISSDDPAMFG-AKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNTFMEIWKK 499
            :.:|:|||..|. .|....:.|.:...:  .|.....:.:||.||:..|        .|....|:
  Fly   688 ISLSTDDPLQFHFTKEPLMEEYSIAAQV--WKLSSCDMCELARNSVMMS--------GFPHAIKQ 742

Human   500 RW 501
            :|
  Fly   743 QW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADA2	NP_001269154.1	adm_rel	30..509	CDD:273620	100/558 (18%)
		Dimerization	30..100		13/100 (13%)
		PRB domain	127..185		8/66 (12%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	107/587 (18%)