Protein Alignment Tnk2 and Ack

DIOPT Version :10

• Sequence 1: XP_006522395.1
• Gene: Tnk2 / 51789
• MGIID: 1858308
• Length: 1087
• Species: Mus musculus
• Sequence 2: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Alignment Length: 1174
• Identity: 394/1174 - (33%)
• Similarity: 544/1174 - (46%)
• Gaps: 234/1174 - (19%)

Mouse    28 LGSSSMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLW 92
            |||.       |.||.:||.||||:|:..|:||||.:|||:||:||..:|||:.|:|:|..|||.
  Fly    11 LGSE-------TAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLM 68

Mouse    93 EAVKRRKAMCKRKSWMSKVFSGKRLEAEFPSQHSQSTFRKPSPTPGSLPGEGTLQSLTCLIGEKD 157
            |||:::||...||:.:||:..|    .:.||...||:..:.|.     .|.||  .|||||.|||
  Fly    69 EAVRKKKAHQWRKNILSKLIGG----GKQPSSKKQSSAARESS-----QGNGT--QLTCLIHEKD 122

Mouse   158 LRLLEKLGDGSFGVVRRGEWDA-PAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 221
            :.:..|||||||||||||||.| ||||.:.||||.||.|.|:||..:|||.|||.|||:|||.||
  Fly   123 ITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANL 187

Mouse   222 IRLYGVVLTLPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLA 286
            :|||||||:.||.|:||||..|||||.|||...|..|..:..::||:..||||||.|||:|||||
  Fly   188 VRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLA 252

Mouse   287 ARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVT 351
            .||:|||..:.:|||||||||||||.||.|||.||:||||.|||||||:.|.|||||||||||||
  Fly   253 CRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVT 317

Mouse   352 LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF 416
            |||||::|::||:||||||||.|||:|||||.:|:.||.|:|.:|:|||...|.:||||.||:::
  Fly   318 LWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEY 382

Mouse   417 LLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGL 481
            |....|..|||.:...|...|.|:..|.|.:|:||.|....:|||.||..:|.||||::......
  Fly   383 LASMSPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVG 447

Mouse   482 SAQDISQPLQNSFIHTGHGDSDPRHCWG-------FPDRIDELYLGNPMDPPDLLSVELSTSR-- 537
            :|.|:   :..|.:..|...|....|||       ..||  :....:..:.|.....:.::|:
  Fly   448 AAGDV---VMRSSVGNGSSSSPFGFCWGGAAAMANGDDR--QRKCASMTNQPHAKERKSTSSKQF 507

Mouse   538 -----------------PTQHLGRV---KREPPPRPPQPAIFTQ-KPTYDPVSE----------D 571
                             ..:|.|.|   :|.|||:..|..|... .|...|::|          |
  Fly   508 AYNKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGD 572

Mouse   572 PDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKADRSSGGEVTLID--FGEEPVVPTPRPCAP 634
            ...|.:|.....|..|            ..|| |.|..|..|::.:..  :.|:|
  Fly   573 SSSLQADSSFCILDAP------------IDVP-TYAGSSGSGDLNVSPTYYNEQP---------- 614

Mouse   635 SLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVV----------DWDARPLPPPPAYDDVAQDE 689
               |...|...:     ..||.|..|.|....|..          |...:.|..|      .::.
  Fly   615 ---QFDFDPAKM-----TASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATP------VRER 665

Mouse   690 DDFEVCSINSTL---------VGAGLPAGPSQGETNYAFVPEQAQMPPALEDNLFLPPQGGGKPP 745
            |.|:..::.:|:         :.|..|..|....             |::..:||    ||.|
  Fly   666 DPFDTTNVETTVALYSNFNQSLEAASPPAPIYNS-------------PSVRKSLF----GGSK-- 711

Mouse   746 SSVQTAEIFQALQQECMRQLQVPTGQLT-------------PSPTPGGD----DKPQVPPRVPIP 793
               ...|...||:...|   |:....||             |.|.|.||    ||..:
  Fly   712 ---SNKENIPALESAAM---QLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFI------- 763

Mouse   794 PRPTRPRVELSPAPSGEEETSRWPGPASPPRVPPREPLSPQGSRTPSPL---VPPGSSPLPHRLS 855
                 ..:|.....:|:..........|......::.:..|..   :||   ..|||   .|...
  Fly   764 -----AELEKDMYSNGQNRAQEEYQRNSTQMYASKDMVYKQNL---TPLKNGAAPGS---VHSNH 817

Mouse   856 SSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLER-Y 919
            |||..|        :.||....:...|........:..|..:....:.:.||..|......|: |
  Fly   818 SSPSST--------ASPKQNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIY 874

Mouse   920 QRFLREAQSPEE--PAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGA--- 979
            |....:.|..:|  .:.:.:...:..|...|.:: ||::.....|:......:....:..||
  Fly   875 QNHRHQQQQQQELNHSFVAISNRVVAPKNNAYSS-TASLYDAVAASTAGSTYYGQVPNGSGAVLY 938

Mouse   980 ----RPPSLRATARLPQRGCPGDGQEAARPADKV------------------------------Q 1010
                :...||.|...|....|...|:..|..:|:                              |
  Fly   939 DEVTQDDYLRPTRPAPLAPPPLSAQQIQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKLQQ 1003

Mouse  1011 MLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCH 1075
            ::|.:......::.:.||::.|..|..|.::.|::||..||:..|.:|.:.|:..:|:||.|...
  Fly  1004 LMQELGSSAVEQDVRNALRAASGDVGLATRHYKIDQLARLGVAGRPQCEQALQQTNWSLEVAAEL 1068

Mouse  1076 LLGS 1079
            ||.:
  Fly  1069 LLNA 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnk2	XP_006522395.1	SAM_TNK-like	38..99	CDD:188938	34/60 (57%)
		PTKc_Ack_like	162..419	CDD:270636	175/257 (68%)
		SH3_9	427..476	CDD:434066	20/48 (42%)
		GTPase_binding	481..546	CDD:430374	15/93 (16%)
		PHA03247	<626..1004	CDD:223021	76/426 (18%)
		Inhibitor_Mig-6	821..887	CDD:463294	15/68 (22%)
		UBA_ACK1	1008..1051	CDD:270460	11/72 (15%)
		UBA_TNK1	1038..1077	CDD:270513	13/38 (34%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	34/67 (51%)
		PTKc_Ack_like	128..385	CDD:270636	175/256 (68%)
		UBA_TNK1	1031..1070	CDD:270513	13/38 (34%)