Protein Alignment MAP3K20 and YPL150W

DIOPT Version :9

• Sequence 1: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Sequence 2: NP_015175.1
• Gene: YPL150W / 855953
• SGDID: S000006071
• Length: 901
• Species: Saccharomyces cerevisiae
• Alignment Length: 885
• Identity: 180/885 - (20%)
• Similarity: 334/885 - (37%)
• Gaps: 191/885 - (21%)

Human     2 SSLGASFVQIKFDDL------QFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
            ||....:.|...|:|      :..:..|.||||.||.|......::|.:|...|.:... :..|.
Yeast    21 SSYNRLYSQFTSDELTEVGNYKILKQIGEGSFGKVYLALHRPTHRKVCLKTSDKNDPNI-VREVF 84

Human    61 SHRN-----IIQFYGVILEPPNYGIVTEYASLGSLYDYINS-NRSEEMDMDHIMTWATDVAKGMH 119
            .||.     |.:.|.||:......:..||.....|||::.| .|...::...:.   ..::..::
Yeast    85 YHRQFDFPYITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELF---AQISGAVY 146

Human   120 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPV 183
            |.|   .:..:|||||..|:::..:|..|:.|||.:| ....||..::.||..:||||:|:....
Yeast   147 YAH---SMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTY 208

Human   184 SE-TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE---KNERLTIPSSCPRSFAELLHQCWE 244
            .. ..|.:|.||:|:.::|..:||...:..:..|.:|.   |.:...||...    .:|:.:...
Yeast   209 DGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPDDA----RDLISRLLA 269

Human   245 ADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER--LKKLERD----LSF 303
            .:..:|||..|::.........:.:.|:....|..:.....:.::.|||  ||:|::.    .:.
Yeast   270 KNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSKLERRLLKRLKQSGVDTQAI 334

Human   304 KEQELKERERRLK-MW-----------EQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGD 356
            |:..||::...|. :|           ..|..::|.:.|.....|.:.|.:|.....:.:::
Yeast   335 KQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKVIESATHNDTNGISEDVLK--- 396

Human   357 SSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG--HIIHFKSAIEKLTHDYINLFHFPP 419
            .|.|:|..|||.|                     :::||  .:........|.:.|...:.: |.
Yeast   397 PSLELSRAASLSK---------------------MLNKGSDFVTSMTPVSRKKSKDSAKVLN-PT 439

Human   420 LIKDS---------GGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKD 475
            |.|.|         .|.|.::...:..:...|             |.|.....:.:.
Yeast   440 LSKISSQRAYSHSIAGSPRKSNNFLQKVSSFF-------------KSKKSSNSNSNN-------- 483

Human   476 VTFNTNLPDAEILKMTKPP---FVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRT 537
             :.:||:.::.|......|   ..::|....|.||:|        ..|..|..|:.:.|:.
Yeast   484 -SIHTNVSESLIASNRGAPSSGSFLKKNSGSIQKSRT--------DTVANPSRTESIGSLN---- 535

Human   538 KPQDEVKAV--QLAIQTLFTN--SDGN-------PGSRSDSSADCQWLDTLRMRQIASNTSLQRS 591
              ::...|:  :.|..|...|  :.||       |....:....   ::..|:::..|:.|.:.|
Yeast   536 --ENVAGAIVPRSANNTTLENKKTSGNEIGLKVAPELLLNEHIR---IEEPRLKRFKSSISSEIS 595

Human   592 QSNPILGSPFFSHFDGQD-------SYAAAVRRPQVPIKYQQITPVNQ-SRSSSPTQYGLTKNFS 648
            |::.       .::|.:.       |:...|..|  ||:.:.::.::| |..:..::|....|.|
Yeast   596 QTST-------GNYDSESAENSRSISFDGKVSPP--PIRNRPLSEISQISNDTYISEYSTDGNNS 651

Human   649 SLHLNS--RDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYP 711
            |..::.  :.|....| ::|:|:....|::..|.|||..:..:.|.....|     ||..|....
Yeast   652 SFKISDTIKPSYIRKG-SETTSQYSASSEKMTNGYGRKFVRRDLSIVSTAS-----STSERSSRT 710

Human   712 GKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGM-PLHPETDSR-------------------- 755
            ..||.::.:  .|..:.|.:|:..:..:.:.:|.. ...|.|..|
Yeast   711 DSFYDITTA--TPVVTTDNRRNKNNNLKESVLPRFGTQRPWTGKRTYTTSRHGKNARRSSKRGLF 773

Human   756 ---ASEEDSKVSEGGWTKVE-----YRKKPHRPSPAKTNK 787
               :|..||.:.|...::.|     |.|....|:|....|
Yeast   774 KITSSNTDSIIQEVSSSEEEDHNVIYSKGKGLPTPVLQTK 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	66/251 (26%)
		STYKc	23..260	CDD:214568	66/247 (27%)
		Leucine-zipper	287..308		7/26 (27%)
		SAM_MLTK	338..408	CDD:188928	12/71 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		33/167 (20%)
YPL150W	NP_015175.1	STKc_AMPK-like	40..286	CDD:270905	66/256 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910