Protein Alignment MAP3K20 and KIN4

DIOPT Version :9

• Sequence 1: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Sequence 2: NP_014876.1
• Gene: KIN4 / 854408
• SGDID: S000005759
• Length: 800
• Species: Saccharomyces cerevisiae
• Alignment Length: 861
• Identity: 168/861 - (19%)
• Similarity: 287/861 - (33%)
• Gaps: 263/861 - (30%)

Human    23 GGGSFGSVYRAKWISQD------KEVAVK------------KLLKIEKEAEILSVLSHRNIIQFY 69
            |.|.||.| :..|....      |:||:|            |.:||.:|...|..|:|.|||...
Yeast    53 GEGEFGKV-KLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLE 116

Human    70 GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDL 134
            .|:......|||.|:.|.|..|.||  .|...:...........:..|::|:|.:.   ::||||
Yeast   117 EVLQNSKYIGIVLEFVSGGEFYKYI--QRKRRLKESSACRLFAQLISGVNYMHYKG---LVHRDL 176

Human   135 KSRNVVIAADGVLKICDFGASR--FHNHTTHMSLVGTFPWMAPEVIQSLPVSET--CDTYSYGVV 195
            |..|:::.....|.|.|||...  |.::....:..|:..:.|||::.|....|.  .|.:|.||:
Yeast   177 KLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVI 241

Human   196 LWEMLTREVPF----KGLEGLQVAWLV----------------VEKN--ERLTIPSSCPR----- 233
            |:.||...:|:    :...|..:|.|.                :.::  .|:.:|:  ||
Yeast   242 LYAMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPN--PRRRINL 304

Human   234 -------------SFAELLHQCWEADAKK---RPSFKQIISILESMSNDTSLPDKC---NSFLHN 279
                         :|..:....|:...:|   :|..|..:....:.|:..|...|.   ||.:
Yeast   305 QTIKRHVWLKPHEAFLSIQPNYWDEHLQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLI-- 367

Human   280 KAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQ--SNTPLLPSFEIGAWTED 342
                   ||:|||                          :.:::.|  ::.|..|:|..|:
Yeast   368 -------IESTLE--------------------------QHRMSPQLATSRPASPTFSTGS---- 395

Human   343 DVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKL 407
                    .|...|:..:|       ||:||.|:|                       .||..:.
Yeast   396 --------KVVLNDTKNDM-------KESNINGER-----------------------TSASCRY 422

Human   408 THDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITY 472
            |             :||.|..:      ..:|.|...|...|        ..:..:.| .:.|..
Yeast   423 T-------------RDSKGNGQ------TQIEQVSARHSSRG--------NKHTSVAG-LVTIPG 459

Human   473 IKDVTFNTNLPDAEILKMTK----PPFVMEKW-IVGIAKSQTVECTVTYESDVRTPKSTKHVHSI 532
            ........|.|.:::.:..|    ..|..|:: .:|           .|......|:.|.:...:
Yeast   460 SPTTARTRNAPSSKLTEHVKDSSQTSFTQEEFHRIG-----------NYHVPRSRPRPTSYYPGL 513

Human   533 QWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSS--ADCQWLDTLRMRQIASNTSLQRSQSNP 595
              ||....:.:..:.:       |..|:.|..:|:.  .....:.......|::|:.:..|:...
Yeast   514 --SRNTADNSLADIPV-------NKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLSEGPA 569

Human   596 ILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGL----------------- 643
            ...||...|:...|     :.....||. :.|..:|:..:....:.|.
Yeast   570 AKTSPVDYHYAIGD-----LNHGDKPIT-EVIDKINKDLTHKAAENGFPRESIDPESTSTILVTK 628

Human   644 --TKNFSSLHLNSR--DSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHST 704
              |.:....|:.|:  :.|.||..:|.||::.  |.:...|.....:||.||..|  |..:..|.
Yeast   629 EPTNSTDEDHVESQLENVGHSSNKSDASSDKD--SKKIYEKKRFSFMSLYSSLNG--SRSTVESR 689

Human   705 PSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWT 769
            .|:|..|....|......|.......::.||:|               ..|....|.|:::.
Yeast   690 TSKGNAPPVSSRNPSGQSNRSNIKITQQQPRNL---------------SDRVPNPDKKINDN--- 736

Human   770 KVEYRKKPHRPSPAKT 785
                |.:.:.||.|::
Yeast   737 ----RIRDNAPSYAES 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	72/304 (24%)
		STYKc	23..260	CDD:214568	72/301 (24%)
		Leucine-zipper	287..308		5/20 (25%)
		SAM_MLTK	338..408	CDD:188928	11/69 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		31/136 (23%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	67/267 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910