DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K20 and zak

DIOPT Version :9

Sequence 1:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens
Sequence 2:	NP_001314869.1	Gene:	zak / 559247	ZFINID:	ZDB-GENE-070912-386	Length:	789	Species:	Danio rerio

Alignment Length:	818	Identity:	491/818 - (60%)
Similarity:	601/818 - (73%)	Gaps:	48/818 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNI 65
            |:|||:|||||||||:.|:||||||||||||||:|:|||:|||||||||||||||||||||||||
Zfish     1 MASLGSSFVQIKFDDIHFYENCGGGSFGSVYRARWLSQDREVAVKKLLKIEKEAEILSVLSHRNI 65

Human    66 IQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 130
            |:|||.|||.|||||||||||.|||:||::|:.||::.|..|||||.|:||||||||.|||||||
Zfish    66 IKFYGAILEAPNYGIVTEYASGGSLFDYLSSDDSEDISMQQIMTWAMDIAKGMHYLHSEAPVKVI 130

Human   131 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVV 195
            ||||||||||:::|.||||||||||:||:||||||||||||||||||||||||||||||:|||||
Zfish   131 HRDLKSRNVVLSSDSVLKICDFGASKFHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTFSYGVV 195

Human   196 LWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL 260
            ||||||:|:|||||||||||||||||:||||||||||.|||.|:..||..:.|:||.||.|:|.|
Zfish   196 LWEMLTQEIPFKGLEGLQVAWLVVEKHERLTIPSSCPASFACLMRSCWATEPKERPLFKHILSTL 260

Human   261 ESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQ 325
            |||.:||.||||||:||.|||||||||||||||||:||||||.|||.||||||||||||:||.||
Zfish   261 ESMWSDTQLPDKCNTFLQNKAEWRCEIEATLERLKRLERDLSTKEQALKERERRLKMWERKLIEQ 325

Human   326 SNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMG 390
            |||||||:..|.:|||:.|:.|::|:. :||  .|:..||::|::|:|||:|||||.|.|::|:|
Zfish   326 SNTPLLPNLAIHSWTEEHVHFWMEQIF-EGD--GELQQYANVFRQNHITGQRLLLLSESDMRDLG 387

Human   391 IVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEE--KIVNLELVFGFHLKPGTGPQ 453
            :.|||||||.|:.||||||||:|||||||||||.....|.:|:  |.||||||||:|.|.|||.:
Zfish   388 VTSKGHIIHLKTEIEKLTHDYLNLFHFPPLIKDGSASEEADEDWSKTVNLELVFGYHWKAGTGQK 452

Human   454 DCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYES 518
            |||||||||:||||:||.||||||||.|.||.::||||||||||:||||||:.:.||:..|.||.
Zfish   453 DCKWKMYMELDGDEVAIAYIKDVTFNANRPDVDVLKMTKPPFVMDKWIVGISGTHTVDYIVNYEG 517

Human   519 DVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIA 583
            :|::||.|:|||::|||....:|.:|.|:|.|:|.....:.:..|||:|..|.:|:.:|||:|:.
Zfish   518 NVKSPKCTRHVHTVQWSADSGKDVIKPVELVIETAPGIREAHNRSRSNSGVDPKWIYSLRMKQMK 582

Human   584 SNTSLQRSQSNPILGS--PFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKN 646
            .    |.:|.:|...|  .|.|....|.||||||||..   ....::|...|||||||   |:..
Zfish   583 E----QAAQESPSKMSLPQFLSVISNQSSYAAAVRRSP---NRSPLSPWTDSRSSSPT---LSVK 637

Human   647 FSSLHLNSRDSGFSSGNTDTSSERGR-YSDRSRNKYGRGSI----SLNSSPRGRYSGKSQHSTPS 706
            .|::||.|:.|..||..::::|||.| .|..:::.|.:...    :|..|.||  .|:.:...|.
Zfish   638 LSNMHLGSKGSSPSSTTSESASERERPPSAGAKHNYNKKPYYDHHTLKMSSRG--DGEPRRFLPQ 700

Human   707 RGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSR--ASEEDSKVSEGGWT 769
            ||.      |..|.|..|..:..:...|   |....||||.:..|...:  ||||.   .:|.|.
Zfish   701 RGS------RGFQHAGRPRNAHSYATPP---HYQRPIPGMSMAAEGPKQKVASEEP---GDGDWI 753

Human   770 KVEYRKKPHRPS-------PAKTNKER-ARGDHRGWRN 799
            ||| |||.::..       |.:....| .||..|| ||
Zfish   754 KVE-RKKTNKQECKYQEVRPVRGRSRRGGRGGGRG-RN 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	196/240 (82%)
		STYKc	23..260	CDD:214568	193/236 (82%)
		Leucine-zipper	287..308		18/20 (90%)
		SAM_MLTK	338..408	CDD:188928	36/69 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800		50/163 (31%)
zak	NP_001314869.1	STYKc	16..260	CDD:214568	197/243 (81%)
		PKc_like	22..263	CDD:304357	196/240 (82%)
		SAM_MLTK	338..405	CDD:188928	36/69 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337486
Domainoid	1	1.000	420	1.000	Domainoid score	I4163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32331
Inparanoid	1	1.050	926	1.000	Inparanoid score	I2676
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43990
OrthoDB	1	1.010	-	-		D119875at7742
OrthoFinder	1	1.000	-	-		FOG0008306
OrthoInspector	1	1.000	-	-		oto45881
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3386
SonicParanoid	1	1.000	-	-		X966
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.340