DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K20 and slpr

DIOPT Version :9

Sequence 1:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	223/863 - (25%)
Similarity:	350/863 - (40%)	Gaps:	211/863 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKEAEILSVLSH 62
            :|::::|...|..|.|.|..|:|..:  ..:|||:|...:            :.:||::...|.|
  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY--DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKH 185

Human    63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
            .||....||.|. ....:|.|||..|||    |...:.::..|.::.||..:|:||:|||.|||:
  Fly   186 ENIAALRGVCLN-TKLCLVMEYARGGSL----NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPM 245

Human   128 KVIHRDLKSRNVVI--AADG------VLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVS 184
            .:|||||||.||:|  |.:|      .|||.|||.:|...:|..||..||:.||.||||.....|
  Fly   246 SIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYS 310

Human   185 ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKK 249
            :..|.:||||:|||::|.|.|:||.:.|.||:.|......|.||.:||.::..|:..||:.|..|
  Fly   311 KFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHK 375

Human   250 RPSFKQIISILESM--SNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERE 312
            ||.||:|:..|||:  |..|..|.:  ||.:.:..||.||...|..|::.|:.....|:||:.:|
  Fly   376 RPGFKEILKQLESIACSKFTLTPQE--SFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKE 438

Human   313 RRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKR 377
            .:|...:.:..|::|                       |::              .:|.|:..:.
  Fly   439 EQLLRVQNEQREKAN-----------------------LLK--------------IREQNLRERE 466

Human   378 LLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINL----FHFPPLIKDSG---GEPEENEEKI 435
            .:|:|.|.:....:.||..  |.|....|...  |:|    .|....::|..   |.|..:..:|
  Fly   467 RVLIERELVMLQPVPSKRK--HKKGKKNKPLQ--ISLPTGFRHTITAVRDKAEQPGSPSFSGLRI 527

Human   436 VNLELVFGFHLK---PGTGPQDCKWKMYMEMDG--DEIAITYIKDVTFNTNLPD----------A 485
            |  .|..|...|   |.|..|..:..:..::.|  .|.........:|:.:.|:          .
  Fly   528 V--ALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQ 590

Human   486 EILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQD----EVKAV 546
            ::..:|.||.:   .|:|.:....           .||.:......|....|:|.:    ..||:
  Fly   591 QVASLTPPPGL---GILGGSGGAG-----------GTPATPLLYPGIPIILTRPNNNNIGNCKAI 641

Human   547 QLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSY 611
            ...|.|..|.:..|..:.::|              |::|.:.|.:..:.|       :.:..::.
  Fly   642 TTTITTTTTTTTNNNNNNNNS--------------ISANNNNQLNNISTI-------NSNNNNNQ 685

Human   612 AAAVRRPQVPIKYQQITPVNQSRSSSPTQ-------------YGLTKNFS----SLHLNSRDSGF 659
            .....:|...|..|  ...|.|.||:.:|             |||....:    .|:|.:.|
  Fly   686 TNLTSQPNTIIVLQ--NGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDD--- 745

Human   660 SSGNTDT-SSERG--RYSDRSRNKYGRGSI-------SLNSSP---RGRYS-GKSQHSTPSRG-- 708
             |..||| :|..|  .:.....:....|::       ||.:||   |.::| ..|.|..|:.|
  Fly   746 -SSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSN 809

Human   709 ----------------RYPGKFYR--------VSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLH 749
                            .|...|||        .|...:|       .:|..||...|:  ..||
  Fly   810 SFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVN-------SKSSGDLTMYNS--STPL- 864

Human   750 PETDSRASEEDSKVSEGG 767
               .:|..::..:..|||
  Fly   865 ---TARDCDDAEEAFEGG 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	103/260 (40%)
		STYKc	23..260	CDD:214568	101/256 (39%)
		Leucine-zipper	287..308		5/20 (25%)
		SAM_MLTK	338..408	CDD:188928	11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800		35/156 (22%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	103/263 (39%)
		STKc_MLK	134..389	CDD:270963	103/261 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710