DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K20 and CG8173

DIOPT Version :9

Sequence 1:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens
Sequence 2:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	150/371 - (40%)	Gaps:	56/371 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    25 GSFGSVYRAKWISQDKEVAVKKLL--KIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTE---- 83
            |...|.:..|.|:|:..|....|.  :|..||:||..|.|.||:.|.|||..  :.||.|.
  Fly    52 GEIRSPWAVKRITQNMRVKKDTLFNERIVHEADILRKLKHPNIVGFRGVITN--DEGINTLALEM 114

Human    84 -YASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAAD-GV 146
             ..||||:.:..:......:...|......|||:.:.:||.||  .::|.||||.||::..: .:
  Fly   115 CTTSLGSILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEA--HLMHGDLKSFNVLVKGEFEI 177

Human   147 LKICDFGASRFHNHTTHMSL--------VGTFPWMAPEVIQSLPVSET-CDTYSYGVVLWEMLTR 202
            .|:||||.|...:....::.        |||..|.|||||..:.|.:: .|.:|:|:|::|.|..
  Fly   178 CKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETLAL 242

Human   203 EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT 267
             ||...||      |.....|.:......|....:|  ||.:.|             ..|..|..
  Fly   243 -VPPHTLE------LDAALGEDMDSSHDLPTDTDKL--QCKQLD-------------FSSDENKN 285

Human   268 SLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLP 332
            .||........|......:.|...|..::.|.| ..::.:.||.:..........:.....|.||
  Fly   286 GLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEED-DEEDDDTKENDISYFTLNNLHSAYGTRPPLP 349

Human   333 -SFEIGAWTEDDVYCWVQQL-----VRKGDSSAEMSVYASLFKENN 372
             :|::    .||..|.|:..     ....|..|..:::..|  |||
  Fly   350 VAFQL----SDDYNCVVELFYLCTNALSEDRPAAKTIWQCL--ENN 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	75/254 (30%)
		STYKc	23..260	CDD:214568	75/251 (30%)
		Leucine-zipper	287..308		4/20 (20%)
		SAM_MLTK	338..408	CDD:188928	10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	98/369 (27%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	65/197 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43289
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910