DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K20 and zak-1

DIOPT Version :9

Sequence 1:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens
Sequence 2:	NP_001367790.1	Gene:	zak-1 / 175954	WormBaseID:	WBGene00006971	Length:	745	Species:	Caenorhabditis elegans

Alignment Length:	748	Identity:	220/748 - (29%)
Similarity:	349/748 - (46%)	Gaps:	131/748 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     8 FVQIKFDDLQFFENCGGGSFGSVYRAKWISQD---KEVAVKKLLKIEKEAEILSVLSHRNIIQFY 69
            |..|:.||:|..::.|.|:||:|:...|...|   :.:|:||:..:||||||||.:.|:||||||
Worm    23 FPDIQRDDIQVGDHIGVGTFGAVFSGNWTLPDGSQRTIALKKVFVLEKEAEILSKIRHKNIIQFY 87

Human    70 GVILEPPN-YGIVTEYASLGSLYDYINSNRSEEM-------DMDHIMTWATDVAKGMHYLHMEAP 126
            |:.....| :.||||||..|||||:|:|..|:..       ..|.::.||:.:|.|:.|||.:|.
Worm    88 GICKATGNDFFIVTEYAEKGSLYDFIHSEESQSFASSSGGNSFDVVVKWASQIASGIQYLHYDAV 152

Human   127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT-THMSLVGTFPWMAPE-VIQSLPVSETCDT 189
            ..:|||||||:|||:..:.|.||||||.|:...|: |..|..||..||:|| ::||..::...|.
Worm   153 DTIIHRDLKSKNVVLDKNLVCKICDFGTSKDLTHSCTAPSWGGTAAWMSPEMILQSEGLTTATDV 217

Human   190 YSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFK 254
            :||||||||:|::|||:|.....::..::.:....|.||.|||....:|:..||:...|.|.:.:
Worm   218 WSYGVVLWEILSKEVPYKDYSEFRIFTMITQSGITLAIPPSCPAPLKQLMSNCWKMTPKDRANMR 282

Human   255 QIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKM-- 317
            ||...|..::.:..:.|:|..|: ...:|:.|||...:.::|:.:||..:.::|:.||:.||.
Worm   283 QIQGELNRLAGNQKVMDECEKFM-GLEDWKTEIEKQEKNVEKMRKDLEKRREQLEIREKALKQRM 346

Human   318 -WEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRK--GDSSAEMSVYASLFKENNITGKRLL 379
             .||.:.:.:..|  |. ::..|:|.....||:.::.:  .|......|.|::|: |.|||.|||
Worm   347 KVEQAVLDSARHP--PE-DVHQWSEHHTSHWVETVLGRVANDKKFLDRVNAAVFR-NRITGARLL 407

Human   380 LLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL------------IKDSGGEPEENE 432
            .:.:.||:.:|:...|..|.....|.||......|.:||.|            .|::.|:...:
Worm   408 GMTQNDLEHLGVHKVGSRIELMKMIRKLADTQKALHNFPTLEQAKRIEMTLKTEKEAAGQLAND- 471

Human   433 EKIVNLELVFGFHLKPGTGPQDCKWKMYME---MDGDEI--------AITYIKDVTF-----NT- 480
               |::.::.|.:::.....:. |:|.|.:   :|..:|        |.:.||.|.|     ||
Worm   472 ---VDIVIIVGMYVRKMNATRR-KFKFYADSDWIDDTDIPAKSKSKHASSLIKTVCFSVLDENTK 532

Human   481 ---NLPDAEILK-MTKPPFVMEKWIVGIAKSQT---VECTVTYESDVRTPKST---KHVHSIQWS 535
               |.|...|.. ||..|    .||....:...   |..:|.|...|..|::|   |.|.|::.|
Worm   533 KPINEPACSISSGMTTNP----DWITVDTEDDVKIRVIVSVYYADIVTQPRNTEVIKVVTSLEES 593

Human   536 RTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILG-- 598
            :...:..|.                                ||:|:.:|:.|:  |..:|::.
Worm   594 KILEERHVH--------------------------------LRLRRSSSSASI--STPSPVIAPV 624

Human   599 -SPF------FSHFDGQDSYAAAVRRPQVPIKYQQITPV------NQSRSSSPTQY--------- 641
             .||      |.|............|.|..:....:|..      .|.|:.||.:.
Worm   625 YHPFGHLNNGFHHTTSSPQLRGFWHRKQTGMNRHGLTETELSSLQEQLRTPSPDKKVVDENVIIH 689

Human   642 --GLTKNFSSLHLNSRDSGFSSGNTDTSSERGR 672
              .||:...:...||.|:..|..|..|...:.|
Worm   690 VPKLTRRRRTTTTNSEDTEKSDTNNKTPESQAR 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	107/253 (42%)
		STYKc	23..260	CDD:214568	106/249 (43%)
		Leucine-zipper	287..308		5/20 (25%)
		SAM_MLTK	338..408	CDD:188928	22/71 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800		7/21 (33%)
zak-1	NP_001367790.1	PKc_like	38..291	CDD:419665	107/252 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161464806
Domainoid	1	1.000	202	1.000	Domainoid score	I1928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2098
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274123at33208
OrthoFinder	1	1.000	-	-		FOG0008306
OrthoInspector	1	1.000	-	-		oto22677
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3386
SonicParanoid	1	1.000	-	-		X966
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.830