DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K20 and map3k20

DIOPT Version :9

Sequence 1:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens
Sequence 2:	XP_002934652.2	Gene:	map3k20 / 100495797	XenbaseID:	XB-GENE-985435	Length:	790	Species:	Xenopus tropicalis

Alignment Length:	819	Identity:	563/819 - (68%)
Similarity:	653/819 - (79%)	Gaps:	50/819 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNI 65
            |.||.||||||||||||||||||||||||||||||:||||||||||||||||||||||:|||||:
Frog     1 MLSLTASFVQIKFDDLQFFENCGGGSFGSVYRAKWLSQDKEVAVKKLLKIEKEAEILSMLSHRNV 65

Human    66 IQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 130
            |||||.:||||||.||||||:.|||||||||.|||.|||||||.|:.||||||||||||||::||
Frog    66 IQFYGAVLEPPNYCIVTEYAACGSLYDYINSTRSENMDMDHIMAWSMDVAKGMHYLHMEAPIRVI 130

Human   131 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVV 195
            |||||||||||..||:||||||||||||:||||||||||||||||||||||||||||||||||||
Frog   131 HRDLKSRNVVITMDGILKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVV 195

Human   196 LWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL 260
            |||||||||||||||||||||||||||||||||||||:|||||:|||||||:|||||||||||.|
Frog   196 LWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPQSFAELMHQCWEADSKKRPSFKQIISNL 260

Human   261 ESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQ 325
            ||||||:.|||:||||||||||||||||.||||||:||||||:|||||||||:.|||||:|||||
Frog   261 ESMSNDSKLPDQCNSFLHNKAEWRCEIEETLERLKRLERDLSYKEQELKEREKHLKMWEKKLTEQ 325

Human   326 SNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMG 390
            |:|||||||:|.||||:|||.|:||||:..|.    ::|||||::::|||||||||||.||||||
Frog   326 SHTPLLPSFDICAWTEEDVYVWMQQLVKSDDE----NMYASLFRQHHITGKRLLLLEERDLKDMG 386

Human   391 IVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDC 455
            |||||||||.|:|||||||||:|||||||||||...|.:| |||:||||||||:|||.|:.|:|.
Frog   387 IVSKGHIIHLKTAIEKLTHDYLNLFHFPPLIKDFESENDE-EEKLVNLELVFGYHLKSGSCPEDY 450

Human   456 KWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDV 520
            |||||||:||||||||||||||||.|.||.|.|||||||||||||||||.:::||||.||||:||
Frog   451 KWKMYMELDGDEIAITYIKDVTFNRNQPDVEPLKMTKPPFVMEKWIVGIRENETVECIVTYENDV 515

Human   521 RTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASN 585
            ||||.|||:|.|.|.:.|.||.||:|||||.:....|:... |..:||.||||:.||||||:|:.
Frog   516 RTPKITKHIHKIHWDKMKMQDAVKSVQLAIMSPLLTSESKQ-SNYESSVDCQWIYTLRMRQMATP 579

Human   586 TS------LQRSQSNPILG-SPFFSHFDGQDSYAAAVRR----PQVPIKYQQITPVNQSRSSSPT 639
            ||      |.||||:.:.. |....:...|:||||||||    |.:     |:|.:|.|||||||
Frog   580 TSPQHAAGLPRSQSSSLSNLSQILPYLQNQESYAAAVRRIRASPTL-----QVTSINYSRSSSPT 639

Human   640 QYGLTKNFSSLHL-NSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHS 703
            |:||.||.|||.: :|:.|..||..:|:.|||.| :.|:.|         |||.:     .::||
Frog   640 QFGLAKNLSSLSIQSSKGSSASSTASDSPSERER-AHRTPN---------NSSYQ-----HNRHS 689

Human   704 TP----SRGRYP----GKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEED 760
            ||    |.||.|    ||.|: |.:....|..| |::.|:..:|...||||| ..|:|:..:.|:
Frog   690 TPMQRRSGGRSPQMNSGKNYK-SYTVTYSHSRP-FEQRPQRTNQNRYIPGMP-KLESDAAVNGEE 751

Human   761 SKVSEGGWTKVEYRKKPHR-PSPAKTNKERARGDHRGWR 798
            ...::|||.||:|.||.|: .:.:|::|:|::...||.|
Frog   752 KNNNDGGWIKVDYSKKTHKQTTTSKSHKDRSKSFGRGRR 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	217/240 (90%)
		STYKc	23..260	CDD:214568	214/236 (91%)
		Leucine-zipper	287..308		17/20 (85%)
		SAM_MLTK	338..408	CDD:188928	49/69 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800		54/157 (34%)
map3k20	XP_002934652.2	PKc_like	22..263	CDD:419665	217/240 (90%)
map3k20	XP_002934652.2	SAM_superfamily	338..404	CDD:417767	49/69 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	467	1.000	Domainoid score	I4363
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32331
Inparanoid	1	1.050	1076	1.000	Inparanoid score	I2740
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43990
OrthoDB	1	1.010	-	-		D119875at7742
OrthoFinder	1	1.000	-	-		FOG0008306
OrthoInspector	1	1.000	-	-		oto147992
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3386
SonicParanoid	1	1.000	-	-		X966
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010