Protein Alignment MAP3K20 and map3k20

DIOPT Version :10

• Sequence 1: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Sequence 2: XP_002934652.2
• Gene: map3k20 / 100495797
• XenbaseID: XB-GENE-985435
• Length: 790
• Species: Xenopus tropicalis
• Alignment Length: 819
• Identity: 563/819 - (68%)
• Similarity: 653/819 - (79%)
• Gaps: 50/819 - (6%)

Human     1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNI 65
            |.||.||||||||||||||||||||||||||||||:||||||||||||||||||||||:|||||:
 Frog     1 MLSLTASFVQIKFDDLQFFENCGGGSFGSVYRAKWLSQDKEVAVKKLLKIEKEAEILSMLSHRNV 65

Human    66 IQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 130
            |||||.:||||||.||||||:.|||||||||.|||.|||||||.|:.||||||||||||||::||
 Frog    66 IQFYGAVLEPPNYCIVTEYAACGSLYDYINSTRSENMDMDHIMAWSMDVAKGMHYLHMEAPIRVI 130

Human   131 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVV 195
            |||||||||||..||:||||||||||||:||||||||||||||||||||||||||||||||||||
 Frog   131 HRDLKSRNVVITMDGILKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVV 195

Human   196 LWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL 260
            |||||||||||||||||||||||||||||||||||||:|||||:|||||||:|||||||||||.|
 Frog   196 LWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPQSFAELMHQCWEADSKKRPSFKQIISNL 260

Human   261 ESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQ 325
            ||||||:.|||:||||||||||||||||.||||||:||||||:|||||||||:.|||||:|||||
 Frog   261 ESMSNDSKLPDQCNSFLHNKAEWRCEIEETLERLKRLERDLSYKEQELKEREKHLKMWEKKLTEQ 325

Human   326 SNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMG 390
            |:|||||||:|.||||:|||.|:||||:..|.    ::|||||::::|||||||||||.||||||
 Frog   326 SHTPLLPSFDICAWTEEDVYVWMQQLVKSDDE----NMYASLFRQHHITGKRLLLLEERDLKDMG 386

Human   391 IVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDC 455
            |||||||||.|:|||||||||:|||||||||||...|.:| |||:||||||||:|||.|:.|:|.
 Frog   387 IVSKGHIIHLKTAIEKLTHDYLNLFHFPPLIKDFESENDE-EEKLVNLELVFGYHLKSGSCPEDY 450

Human   456 KWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDV 520
            |||||||:||||||||||||||||.|.||.|.|||||||||||||||||.:::||||.||||:||
 Frog   451 KWKMYMELDGDEIAITYIKDVTFNRNQPDVEPLKMTKPPFVMEKWIVGIRENETVECIVTYENDV 515

Human   521 RTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASN 585
            ||||.|||:|.|.|.:.|.||.||:|||||.:....|:... |..:||.||||:.||||||:|:.
 Frog   516 RTPKITKHIHKIHWDKMKMQDAVKSVQLAIMSPLLTSESKQ-SNYESSVDCQWIYTLRMRQMATP 579

Human   586 TS------LQRSQSNPILG-SPFFSHFDGQDSYAAAVRR----PQVPIKYQQITPVNQSRSSSPT 639
            ||      |.||||:.:.. |....:...|:||||||||    |.:     |:|.:|.|||||||
 Frog   580 TSPQHAAGLPRSQSSSLSNLSQILPYLQNQESYAAAVRRIRASPTL-----QVTSINYSRSSSPT 639

Human   640 QYGLTKNFSSLHL-NSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHS 703
            |:||.||.|||.: :|:.|..||..:|:.|||.| :.|:.|         |||.:     .::||
 Frog   640 QFGLAKNLSSLSIQSSKGSSASSTASDSPSERER-AHRTPN---------NSSYQ-----HNRHS 689

Human   704 TP----SRGRYP----GKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEED 760
            ||    |.||.|    ||.|: |.:....|..| |::.|:..:|...||||| ..|:|:..:.|:
 Frog   690 TPMQRRSGGRSPQMNSGKNYK-SYTVTYSHSRP-FEQRPQRTNQNRYIPGMP-KLESDAAVNGEE 751

Human   761 SKVSEGGWTKVEYRKKPHR-PSPAKTNKERARGDHRGWR 798
            ...::|||.||:|.||.|: .:.:|::|:|::...||.|
 Frog   752 KNNNDGGWIKVDYSKKTHKQTTTSKSHKDRSKSFGRGRR 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	217/240 (90%)
		Leucine-zipper	287..308		17/20 (85%)
		SAM_MLTK	338..408	CDD:188928	49/69 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		54/157 (34%)
		Sensing domain (S). /evidence=ECO:0000269|PubMed:32289254	670..713		15/50 (30%)
		C-terminal domain (CTD). /evidence=ECO:0000269|PubMed:32289254	774..800		9/26 (35%)
map3k20	XP_002934652.2	Protein Kinases, catalytic domain	22..263	CDD:473864	217/240 (90%)
		SAM_superfamily	338..404	CDD:472832	49/69 (71%)