Protein Alignment INPP5K and inpp-5K

DIOPT Version :10

• Sequence 1: NP_057616.2
• Gene: INPP5K / 51763
• HGNCID: 33882
• Length: 448
• Species: Homo sapiens
• Sequence 2: NP_498783.1
• Gene: inpp-5K / 183643
• WormBaseID: WBGene00086546
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 461
• Identity: 119/461 - (25%)
• Similarity: 190/461 - (41%)
• Gaps: 116/461 - (25%)

Human    16 IHVVTWNVASAAPPLDLSDLLQLNNR-NLNLD----IYVIGLQEL-NSGII--SLLSDAAFNDSW 72
            |.:.|:|:|..|     ||...::|. |..:|    :..|||||: :|..|  ::|:.|....||
 Worm     5 ITIFTYNLAMKA-----SDSEAVHNMLNGMIDDHTHLVAIGLQEVAHSETIGGAVLTWATTIASW 64

Human    73 SSFLMD-----VLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGV 132
                |:     ||...:|...:.|       |:|.:.|.:..|:.:..:.....:.|..|:||.:
 Worm    65 ----MNTNGRMVLLAKTFQATNQV-------LIFGRKQLIGQIKRIDYRFQRNTMGGLTGHKGSI 118

Human   133 NICLKLYG-YYVSIINCHLPPHISNNY-QRLE--HFDRILEMQNCEGRDIPNILDHDLIIWFGDM 193
            .:.|:|.. |.:..::.|. .|...|| :|:|  |.:|     ||   ..|.........||||.
 Worm   119 GVRLQLASPYSIVFVDSHF-IHGPENYGKRVEQYHTNR-----NC---SFPEDKSVRAAFWFGDF 174

Human   194 NFRIEDFGLHFVRESIKNRCYGGLWE-KDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYD 257
            |||:|: .::.|...|||..:..|.: ::||..|.........|.|..:.|.|||:....:.:.|
 Worm   175 NFRVEE-DVNTVIRKIKNGTHLELLDTREQLKRALVERDAFIGFHEQPVTFEPTYRVTVGTTEQD 238

Human   258 TSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLEL 322
               .||.|:||||||:  |.....|            ||   |:::.....|||.||...|
 Worm   239 ---GKRVPSWTDRILY--KGDGITG------------LS---YTNNKKAVASDHLPVVAMF---- 279

Human   323 KPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPW------------------DWIGLYKVG 369
              .|:||   ..|:..|.|..:.:.::     :.|.|.                  ||||::...
 Worm   280 --RVTAP---AAPKPQWEVIFEHLPTW-----YTSIPLVGRFQVNELYYKENGSYRDWIGVFPSS 334

Human   370 LRDVNDYVSYAWV---------GDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGI 425
            :.|.....::.:.         |...::|         :.:|||.  ..:.|.|:|..|..:||:
 Worm   335 INDCTTATNWIYAATCFEQVIEGSKFLAC---------EFNNIPA--GNYRLGYFSCHLHCLVGL 388

Human   426 SRPFQI 431
            |:.|||
 Worm   389 SKVFQI 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5K	NP_057616.2	EEP	14..320	CDD:469791	91/321 (28%)
		Catalytic. /evidence=ECO:0000255	16..318		90/319 (28%)
		Required for interaction with GPR78 and PAK1. /evidence=ECO:0000269|PubMed:26940976	318..448		29/141 (21%)
		Required for ruffle localization	321..448		28/138 (20%)
		SKICH	331..431	CDD:465482	23/126 (18%)
inpp-5K	NP_498783.1	IPPc	1..284	CDD:214525	92/330 (28%)
		SKICH	293..394	CDD:465482	21/116 (18%)