DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A2 and CG33298

DIOPT Version :9

Sequence 1:NP_057613.4 Gene:ATP8A2 / 51761 HGNCID:13533 Length:1188 Species:Homo sapiens
Sequence 2:NP_995666.1 Gene:CG33298 / 2768929 FlyBaseID:FBgn0032120 Length:1517 Species:Drosophila melanogaster


Alignment Length:1304 Identity:415/1304 - (31%)
Similarity:626/1304 - (48%) Gaps:262/1304 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    46 SVGDQLEAPA-RTIYLN---------QPHLN-KFRDNQISTAKYSVLTFLPRFLYEQIRRAANAF 99
            :.||:.|..: ||:..|         :.|.| :|..|:|.|.||::|:|:|:.|.||..|.||.:
  Fly   217 NTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLY 281

Human   100 FLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNG---M 161
            |:||.||..:|::|..|:...::|::.:|.:..:|::.||.:|..:|..:| ..|..:.:|   .
  Fly   282 FIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRIN-NTTCRVYDGETER 345

Human   162 WHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQ 226
            :..:.|:|:.|||||.:.|.:.:|||::||.:|:||.:||::|.:||||||||.|:.:....:||
  Fly   346 YKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQ 410

Human   227 TREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGH 291
            :..|..|....:|.:.|...||.|.|.|.......|.:..:.:|||.::|:||.::.|||||.||
  Fly   411 SIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGH 475

Human   292 DTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRS--HGEKNWYIKKMDT 354
            :||.|.|::....|||.||:..|:.::....|||::.:|.:.|...|..|  |....:......|
  Fly   476 ETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLT 540

Human   355 TSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEEL 419
            .:....:...|:|::...:||:||.||:|:.|..|...|:.:.|::....:.....|..|:.|||
  Fly   541 ANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEEL 605

Human   420 GQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPP--PCSDSCDFDDPR 482
            ||::::|:|||||||.|.|.|::|.:.|..|.|.|....:..|......||  | :|:.:.|..:
  Fly   606 GQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIP-NDNLNSDMAQ 669

Human   483 LLKNIEDRHPTAPCIQEFLTLLAVCHTVV----PEKDGDNI------------------------ 519
            |.:... ..|.|..|||||.:||:|:||:    |.:|..|.                        
  Fly   670 LTQGTY-LTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQK 733

Human   520 ----------------------------------------------------------------- 519
                                                                             
  Fly   734 LLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPI 798

Human   520 ----------------------------------------------------------------- 519
                                                                             
  Fly   799 SSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKT 863

Human   520 -----------IYQASSPDEAALVKGAKKLGFVFTARTPFSVIIE--AMGQEQTFGILNVLEFSS 571
                       :|:|.||||.|||..|.........|:|..:::.  ..|..:.:.||.||.|.|
  Fly   864 GTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDS 928

Human   572 DRKRMSVIVR-TPSGRLRLYCKGADNVIFERL------SKDSKYMEETLCHLEYFATEGLRTLCV 629
            .||.||::|| ..|..:.||.||||:.|...|      |.:....|:|...|:.:|.||||.|.:
  Fly   929 SRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVM 993

Human   630 AYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATL 694
            |...|:..:|.:|...:||....|::|.:||.:.:..:|.||.|||||.||||||.|||||||:|
  Fly   994 AKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASL 1058

Human   695 LKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGN-----LL 754
            |.|.|.:|||||||.||||||.||.:|.:|.|.||.|...|.||...||..:.||:.|     .|
  Fly  1059 LSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTL 1123

Human   755 G-----KENDVALIIDGHTLKYAL--SFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRV 812
            |     ::...||::||.||.:.|  ..::...||.|:..|.:|:|||.:||||:.:|.|||:.:
  Fly  1124 GYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEEL 1188

Human   813 KAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTK 877
            ...|||||||||||.|||.|.|||||||.|||||...:|:.:.:|.|||:|||.||.|.|:|:::
  Fly  1189 NLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSR 1253

Human   878 CILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR 942
            .|||.||||.....:..|:....|||||::.::..:.|||:|||:|||..:|::::...::.:|:
  Fly  1254 MILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLK 1318

Human   943 FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKA-LEHDTVLTSGHATDYLFVGNIVYT 1006
            .|.|||..:.|..:....||...::||..||::|:..:.| .|.|             ||...:.
  Fly  1319 NPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESD-------------VGIWEFG 1370

Human  1007 YVVVTVCLKAGL-----ETTAWTKFSHLAVWGSMLTWLVF-----------FGIYSTIWPTIPIA 1055
            ..:...||.|.|     |..:||....|::..|:.::.:|           ||:.|:.|...   
  Fly  1371 TTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIF--- 1432

Human  1056 PDMRGQATMVLSSAHFWLGLFL-----VPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLG 1115
                    :..:||..||.:.|     |....|:..|..........|.:|:..:|   :||  |
  Fly  1433 --------VCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRE---RSR--G 1484

Human  1116 KAVL 1119
            :|:|
  Fly  1485 EALL 1488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8A2NP_057613.4 ATPase-Plipid 68..1106 CDD:273734 401/1256 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1162..1188
CG33298NP_995666.1 PhoLip_ATPase_N 249..299 CDD:292826 22/49 (45%)
ATPase-Plipid 250..1473 CDD:273734 399/1249 (32%)
E1-E2_ATPase 302..>394 CDD:278548 31/92 (34%)
Cation_ATPase <880..965 CDD:289987 32/84 (38%)
HAD_like <1177..1240 CDD:304363 37/62 (60%)
PhoLip_ATPase_C 1223..1468 CDD:292829 76/268 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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