DRSC/TRiP Functional Genomics Resources

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Protein Alignment WWOX and CG2070

DIOPT Version :10

Sequence 1:NP_057457.1 Gene:WWOX / 51741 HGNCID:12799 Length:414 Species:Homo sapiens
Sequence 2:NP_610308.2 Gene:CG2070 / 35706 FlyBaseID:FBgn0033203 Length:325 Species:Drosophila melanogaster


Alignment Length:315 Identity:123/315 - (39%)
Similarity:178/315 - (56%) Gaps:27/315 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   107 YDGSTTAMEI------LQGRDF------TGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMA 159
            |..:.:|:.|      :||..|      ||:|.:|||.|.|||.||....|..||.|.:|||:|.
  Fly    14 YGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMK 78

Human   160 RASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDG 224
            :...|...|::..:...:.|..|||..::|:::||..||.:...||:|:.||.....|..||:||
  Fly    79 KCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDG 143

Human   225 LETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWA 289
            .|....|||:|||.|..||.|||..|||:||:|:||.:|||       |::....|:..|: |..
  Fly   144 FEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRF-------GRIKRDDLNSEKS-YDR 200

Human   290 MLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR------SWWVYTLLFTLARPF 348
            .:||.:|||.|:||:.||.:|||..|||.||:||| ::.:.:.|      ||:...|:..:...|
  Fly   201 KMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPG-VVNTELFRNTPFLGSWFGKLLIAPIIWIF 264

Human   349 TKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSER 403
            .|:.:.||.||:|.|..|.||.:.|.||::|.:......||.::.|:.|||.||:
  Fly   265 IKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEK 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWOXNP_057457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WW 18..47 CDD:459800
Nuclear localization signal. /evidence=ECO:0000250 50..55
WW 60..90 CDD:238122
human_WWOX_like_SDR_c-like 124..407 CDD:187669 116/286 (41%)
Interaction with MAPT. /evidence=ECO:0000250 125..414 115/285 (40%)
Mediates targeting to the mitochondria. /evidence=ECO:0000250 209..273 31/63 (49%)
CG2070NP_610308.2 Rossmann-fold NAD(P)(+)-binding proteins 43..317 CDD:473865 114/282 (40%)
Blue background indicates that the domain is not in the aligned region.

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