DRSC/TRiP Functional Genomics Resources

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Protein Alignment WWOX and CG30491

DIOPT Version :10

Sequence 1:NP_057457.1 Gene:WWOX / 51741 HGNCID:12799 Length:414 Species:Homo sapiens
Sequence 2:NP_610306.1 Gene:CG30491 / 35704 FlyBaseID:FBgn0050491 Length:331 Species:Drosophila melanogaster


Alignment Length:339 Identity:128/339 - (37%)
Similarity:183/339 - (53%) Gaps:43/339 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    85 YLDPRLAFTVDDNPTKPTTRQRYDGSTTAM-----EILQGRDF------TGKVVVVTGANSGIGF 138
            :|..|.||.:.           :.|:||.:     :::||..|      ||||.:|||||:|||.
  Fly     6 FLKSRTAFWLS-----------FTGTTTGLAFFVKDLMQGGQFTKETNETGKVFIVTGANTGIGK 59

Human   139 ETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVP 203
            ||.:..|..|..|.:||||:.:..||...|:.|.....|.....|||...|::||..|||.:...
  Fly    60 ETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVYCRQCDLASQESIRHFVAAFKREQEH 124

Human   204 LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDI 268
            ||||:.||.....|.|||.||:|....|||:|||.|..||.|:|.:|:|:|::.|||.:|...:|
  Fly   125 LHVLINNAGVMRCPRSLTSDGIELQLGVNHMGHFLLTNLLLDLLKKSSPSRIVNVSSLAHTRGEI 189

Human   269 NDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNM------- 326
            |  .|.|:      :...|....||::|||.|:||:.||.:||....||:||:|||.:       
  Fly   190 N--TGDLN------SDKSYDEGKAYSQSKLANVLFTRELAKRLEGTNVTANALHPGVVDTEIIRH 246

Human   327 --MYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQ 389
              .::|.....:|..|.:    ||.|:.:.||.|::|.|..||||.:.|.||::|.....:|.|.
  Fly   247 MGFFNNFFAGLFVKPLFW----PFVKTPRNGAQTSLYVALDPELEKVTGQYFSDCKLKEMAPAAT 307

Human   390 SEETARTLWALSER 403
            ..:||:.|||:||:
  Fly   308 DTQTAKWLWAVSEK 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWOXNP_057457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WW 18..47 CDD:459800
Nuclear localization signal. /evidence=ECO:0000250 50..55
WW 60..90 CDD:238122 1/4 (25%)
human_WWOX_like_SDR_c-like 124..407 CDD:187669 117/289 (40%)
Interaction with MAPT. /evidence=ECO:0000250 125..414 116/288 (40%)
Mediates targeting to the mitochondria. /evidence=ECO:0000250 209..273 29/63 (46%)
CG30491NP_610306.1 Rossmann-fold NAD(P)(+)-binding proteins 45..319 CDD:473865 115/285 (40%)
Blue background indicates that the domain is not in the aligned region.

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