Protein Alignment WWOX and Wwox

DIOPT Version :10

• Sequence 1: NP_057457.1
• Gene: WWOX / 51741
• HGNCID: 12799
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 202/406 - (49%)
• Similarity: 267/406 - (65%)
• Gaps: 14/406 - (3%)

Human     9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQV 73
            |.|||||||||||||||.|.||.|.|.|...:.:||.||:||:.||:.|:||.|||:..||.|:.
  Fly     4 LPDTDSEDELPPGWEERATDDGTVCYVNQQGKTSQWTHPRTGRSKRITGELPLGWEKYYDEQGKR 68

Human    74 FFVDHINKRT---TYLDPRLAFTVDDNPTK--PTTRQRYDGSTTAMEILQGRDFTGKVVVVTGAN 133
            |.  .:||.|   |.:||||||.|:: ||:  ...|||:|..:||:::|.|:|..|:..::||||
  Fly    69 FM--FLNKETQQRTNVDPRLAFAVEE-PTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGAN 130

Human   134 SGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEA--MTLDLALLRSVQHFAEA 196
            .|||:|||:|.|.||..:|.||||.:.|..|:.||.:|...|:...  ..|||:.|||||.|.|.
  Fly   131 CGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195

Human   197 FKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSE 261
            .|.....:..|:.||..||||::.|.|||||||||:||.||||...|:.:.  ....|:||:|||
  Fly   196 IKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF--DYKTRIIVLSSE 258

Human   262 SHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNM 326
            ||||.::  .:..|....|||....||:|:|||.:||||:||:.||.:|...||::..::|||||
  Fly   259 SHRFANL--PVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNM 321

Human   327 MYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSE 391
            :.|::.|::|.|.|||.:.||||||:||.|||::|||...||.||.|:|||||..|.||..::|.
  Fly   322 VSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA 386

Human   392 ETARTLWALSERLIQE 407
            ...:.||.|||.||.|
  Fly   387 ALQQQLWKLSENLIAE 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWOX	NP_057457.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		12/13 (92%)
		WW	18..47	CDD:459800	16/28 (57%)
		Nuclear localization signal. /evidence=ECO:0000250	50..55		2/4 (50%)
		WW	60..90	CDD:238122	14/32 (44%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	139/284 (49%)
		Interaction with MAPT. /evidence=ECO:0000250	125..414		139/285 (49%)
		Mediates targeting to the mitochondria. /evidence=ECO:0000250	209..273		33/63 (52%)
Wwox	NP_609171.1	WW	13..43	CDD:197736	17/29 (59%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	139/284 (49%)