DRSC/TRiP Functional Genomics Resources

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Protein Alignment NLK and bsk

DIOPT Version :10

Sequence 1:NP_057315.3 Gene:NLK / 51701 HGNCID:29858 Length:527 Species:Homo sapiens
Sequence 2:NP_723541.1 Gene:bsk / 44801 FlyBaseID:FBgn0000229 Length:372 Species:Drosophila melanogaster


Alignment Length:397 Identity:132/397 - (33%)
Similarity:204/397 - (51%) Gaps:66/397 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   127 QHSHHPQQQLDIEPD--------RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVF 183
            ||.|:..:..|....        ||||.||.|:|.:..|....:.||:||:...|||:...||.:
  Fly     5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69

Human   184 RELKMLCFFKHDNVLSALDILQPP-HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQ 247
            ||.|::....|.|::..|:...|. :::.|:::|:|.|||.::|.::|  ...|..|.:...|||
  Fly    70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQ 132

Human   248 ILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEIL 312
            :|.|:|:||||||:|||:||.|::|.::|.|||.||||||.  ...:..||..|||:||||||::
  Fly   133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART--AGTTFMMTPYVVTRYYRAPEVI 195

Human   313 MGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHIL 377
            :| ..|:..:||||||||..|::...:||.....|.|.:.|.:.|||||...|:......:.::.
  Fly   196 LG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259

Human   378 RGPHKQPSLPVLYT-------------------LSSQATHEAVHLLCRMLVFDPSKRISAKDALA 423
            ..|.        ||                   .|.:...:|.:||.:|||.||.:|||..:||.
  Fly   260 NRPR--------YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316

Human   424 HPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNP---KFDDTFEKNLSSVRQVKEIIHQFI 485
            |.|::   :.|                   |.|.|..|   .:|.:.::...:|.|.||:|::.:
  Fly   317 HEYIN---VWY-------------------DAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEV 359

Human   486 LEQQKGN 492
            ::.:..|
  Fly   360 MDYEAHN 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NLKNP_057315.3 Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 1..304 72/185 (39%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 1..125
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..72
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..140 4/12 (33%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 124..416 113/316 (36%)
STKc_NLK 137..508 CDD:173748 129/387 (33%)
TQE 298..300 1/1 (100%)
Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949 428..527 12/68 (18%)
Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 434..527 12/62 (19%)
bskNP_723541.1 STKc_JNK 23..359 CDD:270840 127/370 (34%)
Blue background indicates that the domain is not in the aligned region.

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