DRSC/TRiP Functional Genomics Resources

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Protein Alignment NLK and Cdk2

DIOPT Version :10

Sequence 1:NP_057315.3 Gene:NLK / 51701 HGNCID:29858 Length:527 Species:Homo sapiens
Sequence 2:NP_524420.1 Gene:Cdk2 / 42453 FlyBaseID:FBgn0004107 Length:314 Species:Drosophila melanogaster


Alignment Length:295 Identity:109/295 - (36%)
Similarity:154/295 - (52%) Gaps:34/295 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH 208
            ||.|.:|:|:.......|:.|||||:....:.........||:.:|...||.||:...|::...:
  Fly    14 IGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGN 78

Human   209 IDYFEEIYVVTELMQSDLHKI------IVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKP 267
                 .:|::.|.:..||.|:      :.:||     .:|.:::|||..:.:.|:..|||||:||
  Fly    79 -----NLYMIFEYLNMDLKKLMDKKKDVFTPQ-----LIKSYMHQILDAVGFCHTNRILHRDLKP 133

Human   268 GNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFA 332
            .||||::...:|:.||||||...: ..|..|.||||.:|||||||:|::.||..:||||:||||:
  Fly   134 QNLLVDTAGKIKLADFGLARAFNV-PMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFS 197

Human   333 ELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGA------KAHILRGPHKQPSLPVLYT 391
            |::.||.||...|.|.||..|...|.||.    .|...|.      |....|........|:   
  Fly   198 EMIMRRSLFPGDSEIDQLYRIFRTLSTPD----ETNWPGVTQLPDFKTKFPRWEGTNMPQPI--- 255

Human   392 LSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPY 426
                ..|||..|:..||.:||:.||||||||.|.|
  Fly   256 ----TEHEAHELIMSMLCYDPNLRISAKDALQHAY 286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NLKNP_057315.3 Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 1..304 54/165 (33%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 1..125
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..72
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..140
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 124..416 99/283 (35%)
STKc_NLK 137..508 CDD:173748 109/295 (37%)
TQE 298..300 1/1 (100%)
Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949 428..527
Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 434..527
Cdk2NP_524420.1 STKc_CDK1_CdkB_like 8..287 CDD:270829 109/295 (37%)
Blue background indicates that the domain is not in the aligned region.

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