Protein Alignment NLK and CG42366

DIOPT Version :10

• Sequence 1: NP_057315.3
• Gene: NLK / 51701
• HGNCID: 29858
• Length: 527
• Species: Homo sapiens
• Sequence 2: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 109/351 - (31%)
• Similarity: 176/351 - (50%)
• Gaps: 34/351 - (9%)

Human   144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH 208
            :|.|.:|.|........|::||:|:|...:.:......: ||:|.|....|.|::...::::..
  Fly    10 LGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNL-REVKSLKKLSHPNIVKLKEVIREN- 72

Human   209 IDYFEEIYVVTELMQSDLHKIIVS-----PQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPG 268
                :.:|.|.|.|:.:|:::|..     |:|    .:|..|:|:|.||.::|..|..|||:||.
  Fly    73 ----DTLYFVFEYMKENLYQMIKDRDTHLPEP----ELKSILFQVLTGLAFMHRHGFFHRDLKPE 129

Human   269 NLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAE 333
            |||.:...::||.||||||  |:......|..|.|::|||||:|:.|.:|.:.||:|::|||.||
  Fly   130 NLLCSGPDLIKIADFGLAR--EIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAE 192

Human   334 LLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH--KQPSLPVLYTLSSQA 396
            |...|.||...|.:.||..|..:||||..:........|.....|.|.  |.|    |.::.|:.
  Fly   193 LYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVP----LSSVVSRC 253

Human   397 THEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNP 461
            :...:.||..||.:||.||.:|:.:|.:||....:....|...|.....:: :...|:..||
  Fly   254 SQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTAATKANVRLNS-KYAASNGHPV--- 314

Human   462 KFDDTFEKNLSSVRQ----VKEIIHQ 483
               .:...|:..|::    |.|::||
  Fly   315 ---QSVSNNVLPVQEKLQAVTELLHQ 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLK	NP_057315.3	Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	1..304		50/164 (30%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..140
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	124..416		93/278 (33%)
		STKc_NLK	137..508	CDD:173748	109/351 (31%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949	428..527		11/60 (18%)
		Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	434..527		11/54 (20%)
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	97/289 (34%)