Protein Alignment NLK and rl

DIOPT Version :10

• Sequence 1: NP_057315.3
• Gene: NLK / 51701
• HGNCID: 29858
• Length: 527
• Species: Homo sapiens
• Sequence 2: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 357
• Identity: 148/357 - (41%)
• Similarity: 214/357 - (59%)
• Gaps: 34/357 - (9%)

Human   144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH 208
            ||.||:|:|.|..|....:|||:||: :.|::...|:|..||:.:|..|||:|::...|||:...
  Fly    44 IGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDS 107

Human   209 IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN 273
            ||...::|:|..||::||:|:: ..|.||:||:..|||||||||||:|||.:||||:||.|||:|
  Fly   108 IDQMRDVYIVQCLMETDLYKLL-KTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 171

Human   274 SNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG 336
            ..|.||||||||||:  .|.|.:..:|:.|.|::||||||::.|:.|:.:|||||||||.||:|.
  Fly   172 KTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 236

Human   337 RRILFQAQSPIQQLDLITDLLGTPSLEAMRTAC---EGAKAHILRGPHKQPSLPVLYTLSSQATH 398
            .|.:|..:..:.||:.|..:||:||.:.:.  |   |.|:.::...|.| |::| ...|...|..
  Fly   237 NRPIFPGKHYLDQLNHILGVLGSPSRDDLE--CIINEKARNYLESLPFK-PNVP-WAKLFPNADA 297

Human   399 EAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKF 463
            .|:.||.:||.|:|.|||..::|||||||::                    .|....|||....|
  Fly   298 LALDLLGKMLTFNPHKRIPVEEALAHPYLEQ--------------------YYDPGDEPVAEVPF 342

Human   464 DDTFEKNLSSVRQVKEIIHQFIL---EQQKGN 492
            ....|.:..|...:|.:|.:..|   |:|..|
  Fly   343 RINMENDDISRDALKSLIFEETLKFKERQPDN 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLK	NP_057315.3	Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	1..304		79/161 (49%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..140
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	124..416		126/276 (46%)
		STKc_NLK	137..508	CDD:173748	148/357 (41%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949	428..527		13/68 (19%)
		Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	434..527		13/62 (21%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	144/347 (41%)