DRSC/TRiP Functional Genomics Resources

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Protein Alignment NLK and p38c

DIOPT Version :10

Sequence 1:NP_057315.3 Gene:NLK / 51701 HGNCID:29858 Length:527 Species:Homo sapiens
Sequence 2:NP_996277.1 Gene:p38c / 2768679 FlyBaseID:FBgn0267339 Length:356 Species:Drosophila melanogaster


Alignment Length:364 Identity:124/364 - (34%)
Similarity:193/364 - (53%) Gaps:62/364 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   140 PD-----RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLS 199
            ||     |.:|.|:||.|..|.........|:|::...|:.....|..:||:::|....|.||:|
  Fly    17 PDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVIS 81

Human   200 ALDILQPP--HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILH 262
            .|::..||  ::..|:::|:||.||.:|||:...|.: :|...:::.||||||||||:||||::|
  Fly    82 LLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-MSDQEIRIILYQILRGLKYIHSAGVVH 145

Human   263 RDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSV 327
            ||:||.|:.||.|..::|.||||:|:    .:..||..|.|.:|.||||:.....|:.|||:|||
  Fly   146 RDLKPCNIAVNGNSEVRILDFGLSRM----CADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSV 206

Human   328 GCIFAELLGRRILFQAQSPIQQLDLITDLLGTP--------SLEAMRTACEGAKA-------HIL 377
            |||.|||:..|:||:.::.:.|:..:.:::|||        |:|..|...||...       |:.
  Fly   207 GCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLF 271

Human   378 RGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCC 442
            .|          |.:      :|:.|:.:||...|.|||:|.:|:.||||.:....:|       
  Fly   272 MG----------YDV------QAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHH------- 313

Human   443 FSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481
                    :..|    |.|.:|..||..:..|:..||::
  Fly   314 --------HAED----TAPVYDQNFENMVLPVKCWKELV 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NLKNP_057315.3 Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 1..304 66/170 (39%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 1..125
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..72
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..140 124/364 (34%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 124..416 106/297 (36%)
STKc_NLK 137..508 CDD:173748 124/364 (34%)
TQE 298..300 1/1 (100%)
Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949 428..527 10/54 (19%)
Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 434..527 10/48 (21%)
p38cNP_996277.1 STKc_p38 4..349 CDD:143356 124/364 (34%)
Blue background indicates that the domain is not in the aligned region.

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