| Sequence 1: | NP_057315.3 | Gene: | NLK / 51701 | HGNCID: | 29858 | Length: | 527 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001022805.1 | Gene: | lit-1 / 176808 | WormBaseID: | WBGene00003048 | Length: | 634 | Species: | Caenorhabditis elegans |
| Alignment Length: | 588 | Identity: | 299/588 - (50%) |
|---|---|---|---|
| Similarity: | 359/588 - (61%) | Gaps: | 133/588 - (22%) |
- Green bases have known domain annotations that are detailed below.
|
Human 22 AAAAGHHHHHH---------------HHLPHLP-------------------PPH--LH------ 44
Human 45 ---------HHHHPQ--------HHLHPGSAAAV----------HPVQQ--------HTSSAAAA 74
Human 75 AAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIE 139
Human 140 PDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDIL 204
Human 205 QPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGN 269
Human 270 LLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAEL 334
Human 335 LGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSS--QAT 397
Human 398 HEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFS--TSTGRVYTSDFEPVTN 460
Human 461 PKFDDTFEKNLS--SVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSP 523
Human 524 LVW 526 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NLK | NP_057315.3 | Required for interaction with TAB2. /evidence=ECO:0000250 | 1..304 | 172/358 (48%) | |
| Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 | 1..125 | 40/179 (22%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 22..72 | 30/126 (24%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 90..140 | 7/49 (14%) | |||
| Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 | 124..416 | 204/293 (70%) | |||
| STKc_NLK | 137..508 | CDD:173748 | 246/376 (65%) | ||
| TQE | 298..300 | 1/1 (100%) | |||
| Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250 | 428..527 | 47/103 (46%) | |||
| Required for interaction with TAB2. /evidence=ECO:0000250 | 434..527 | 42/97 (43%) | |||
| lit-1 | NP_001022805.1 | STKc_NLK | 239..616 | CDD:173748 | 246/376 (65%) |
| S_TKc | 244..531 | CDD:214567 | 207/286 (72%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C161450509 | |
| Domainoid | 1 | 1.000 | 424 | 1.000 | Domainoid score | I342 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H88836 | |
| Inparanoid | 1 | 1.050 | 545 | 1.000 | Inparanoid score | I687 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S657 |
| OMA | 1 | 1.010 | - | - | QHG47979 | |
| OrthoDB | 1 | 1.010 | - | - | D309855at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0005673 | |
| OrthoInspector | 1 | 1.000 | - | - | oto22570 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_107580 | |
| Panther | 1 | 1.100 | - | - | O | PTHR24055 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2681 |
| SonicParanoid | 1 | 1.000 | - | - | X4072 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.890 | |||||