Protein Alignment NLK and lit-1

DIOPT Version :10

• Sequence 1: NP_057315.3
• Gene: NLK / 51701
• HGNCID: 29858
• Length: 527
• Species: Homo sapiens
• Sequence 2: NP_001022805.1
• Gene: lit-1 / 176808
• WormBaseID: WBGene00003048
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 299/588 - (50%)
• Similarity: 359/588 - (61%)
• Gaps: 133/588 - (22%)

Human    22 AAAAGHHHHHH---------------HHLPHLP-------------------PPH--LH------ 44
            ||.|.||.||.               ||..|.|                   |||  ||
 Worm    97 AAVAAHHQHHQQLHPSVQYQLVAAATHHNHHQPQAAQPHYSAVVPRSDVIQQPPHFALHHHLQNL 161

Human    45 ---------HHHHPQ--------HHLHPGSAAAV----------HPVQQ--------HTSSAAAA 74
                     ||||.|        .|.||.:..:.          ..|||        |.||.|..
 Worm   162 VQQQQQQQAHHHHQQLVGEMALVSHTHPAAVGSTTCYEKNQQKQQQVQQIPTQPQVAHVSSNAIL 226

Human    75 AAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIE 139
            |||             ||::|.|               ||                      |.:
 Worm   227 AAA-------------QPFYPPP---------------VQ----------------------DSQ 241

Human   140 PDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDIL 204
            ||||||||||||||||||||.||||||||||||||||.||||||||:|||..|:||||||.||||
 Worm   242 PDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDIL 306

Human   205 QPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGN 269
            ||.:..:|:|:||:||||||||||||||||.|:.||||||:|||||||||||:|.||||||||||
 Worm   307 QPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGN 371

Human   270 LLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAEL 334
            |||||||:||||||||||..:..:..:||.|||||||||||:|||:|.|:.|:||||||||||||
 Worm   372 LLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAEL 436

Human   335 LGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSS--QAT 397
            |.|:|||||..||:||.:|.|||||||.|||:.||||||.|:||...:.|....||.::|  ...
 Worm   437 LQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKN 501

Human   398 HEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFS--TSTGRVYTSDFEPVTN 460
            ||||.||.::|.|||.||||.::||.|.||:|||||:|:|||.||::  ....|::..|.:|...
 Worm   502 HEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCYTKPNMPSRLFAQDLDPRHE 566

Human   461 PKFDDTFEKNLS--SVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSP 523
            ..||..:||::|  |:.:::|.::||::::.....|.|||||||||:|:|.||:|||.||:||||
 Worm   567 SPFDPKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSP 631

Human   524 LVW 526
            ..|
 Worm   632 QAW 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLK	NP_057315.3	Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	1..304		172/358 (48%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	1..125		40/179 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72		30/126 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..140		7/49 (14%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	124..416		204/293 (70%)
		STKc_NLK	137..508	CDD:173748	246/376 (65%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949	428..527		47/103 (46%)
		Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	434..527		42/97 (43%)
lit-1	NP_001022805.1	STKc_NLK	239..616	CDD:173748	246/376 (65%)