Protein Alignment NLK and nlk

DIOPT Version :9

• Sequence 1: NP_057315.3
• Gene: NLK / 51701
• HGNCID: 29858
• Length: 527
• Species: Homo sapiens
• Sequence 2: NP_001116885.1
• Gene: nlk / 100144638
• XenbaseID: XB-GENE-483544
• Length: 534
• Species: Xenopus tropicalis
• Alignment Length: 538
• Identity: 508/538 - (94%)
• Similarity: 514/538 - (95%)
• Gaps: 15/538 - (2%)

Human     1 MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHH--HPQHHLHPGSAAAVHP 63
            |||||..:||.||||||||||.||.||||||||||.|||||||||||  ||||||||||||||||
 Frog     1 MSLCGTSSNANMMAAYNGGTSTAAGGHHHHHHHHLAHLPPPHLHHHHHLHPQHHLHPGSAAAVHP 65

Human    64 VQQH--------TSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAA-APAQVQAAAAA 119
            ||||        :|||||||||||||||||||||.|.|||||||||||||||| |||||||||
 Frog    66 VQQHVSSSSASTSSSAAAAAAAAAAAAAMLNPGQAQSYFPSPAPGQAPGPAAAVAPAQVQAAA-- 128

Human   120 TVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFR 184
             ||||||||||| .|||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   129 -VKAHHHQHSHH-AQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFR 191

Human   185 ELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQIL 249
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   192 ELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQIL 256

Human   250 RGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMG 314
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   257 RGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMG 321

Human   315 SRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRG 379
            ||||:||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   322 SRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRG 386

Human   380 PHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFS 444
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   387 PHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFS 451

Human   445 TSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFI 509
            ||:||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   452 TSSGRVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFI 516

Human   510 SSTVAQPSEMPPSPLVWE 527
            ||||||||||||||||||
 Frog   517 SSTVAQPSEMPPSPLVWE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLK	NP_057315.3	Required for interaction with TAB2. /evidence=ECO:0000250	1..304		287/313 (92%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	1..125		110/134 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72		45/59 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..140		42/50 (84%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679	124..416		287/291 (99%)
		STKc_NLK	137..508	CDD:173748	366/370 (99%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250	428..527		96/98 (98%)
		Required for interaction with TAB2. /evidence=ECO:0000250	434..527		90/92 (98%)
nlk	NP_001116885.1	STKc_NLK	144..515	CDD:173748	366/370 (99%)
		S_TKc	146..434	CDD:214567	285/287 (99%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	577	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88836
Inparanoid	1	1.050	1025	1.000	Inparanoid score	I2989
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47979
OrthoDB	1	1.010	-	-		D138335at32523
OrthoFinder	1	1.000	-	-		FOG0005673
OrthoInspector	1	1.000	-	-		oto157382
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080