Protein Alignment SUFU and Su(fu)

DIOPT Version :10

• Sequence 1: XP_011538160.1
• Gene: SUFU / 51684
• HGNCID: 16466
• Length: 527
• Species: Homo sapiens
• Sequence 2: NP_536750.2
• Gene: Su(fu) / 41565
• FlyBaseID: FBgn0005355
• Length: 468
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 180/531 - (33%)
• Similarity: 255/531 - (48%)
• Gaps: 128/531 - (24%)

Human    31 PPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGL 95
            ||||.||.....::||:||||||||.::||||||.|||||:|||...|....|:|.|||||||||
  Fly    15 PPGLKAIIDHLGQVYPNQPNPLQVTTLLKYWLGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGL 79

Human    96 SDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGE-----------SAPPTWPAELMQGLARYVF 149
            |||:||.|||........||.||||||||.:...|           ..||||||.|:|.:.||.|
  Fly    80 SDLHGDERVHLREEGVTRSGMGFELTFRLAKTEIELKQQIENPEKPQRPPTWPANLLQAIGRYCF 144

Human   150 QSENTFCSGDHVSWHSPLDNS-ESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQ 213
            |:.|..|.||::.|...||.| .|::|::|:.:|||:..:.||.|.|.|.|||||..:||..|.:
  Fly   145 QTGNGLCFGDNIPWRKSLDGSTTSKLQNLLVAQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASR 209

Human   214 WNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDP----HLQQERVDKGIETDGSNLSGVSAKC 274
            |||:|:|..||.....||.||:|:|.|..::||:.|    :||.:     :|..||:|:||:|..
  Fly   210 WNGRGVLNFLRQDMQTGGDWLVTNMDRQMSVFELFPETLLNLQDD-----LEKQGSDLAGVNADF 269

Human   275 AWDDLSRPPE---------------DDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPV 324
            .:.:|....|               :||::|.:           .||:..||          :|.
  Fly   270 TFRELKPTKEVKEEVDFQALSEKCANDENNRQL-----------TDTQMKRE----------EPS 313

Human   325 LPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGR 389
            .|.......|.| |...|.   ..::.:...|         .|:.:.:.........:.|.::.|
  Fly   314 FPQSMSMSSNSL-HKSCPL---DFQAQAPNCI---------SLDGIEITLAPGVAKYLLLAIKDR 365

Human   390 LLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQRPPSCELPSRPVCSPSCVHSF 454
            :.||||||:|:  ..:|:|.|:..|.|:..|...||...|.|:|
  Fly   366 IRHGRHFTFKA--QHLALTLVAESVTGSAVTVNEPYGVLGYWIQ--------------------- 407

Human   455 LVISQRGNFCSWQLTIPRGNLILLTEEFVEKMLED-----LEDLTSPEEFKLPKEYSWPEKKLKV 514
                                 :|:.:|.|.:::||     |::...|:| :|  |..||:|.||
  Fly   408 ---------------------VLIPDELVPRLMEDFRSAGLDEKCEPKE-RL--ELEWPDKNLK- 447

Human   515 SILPDVVFDSP 525
                 ::.|.|
  Fly   448 -----LIIDQP 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUFU	XP_011538160.1	SUFU	64..240	CDD:461543	92/187 (49%)
		SUFU_C	254..516	CDD:463598	59/281 (21%)
Su(fu)	NP_536750.2	SUFU	48..237	CDD:461543	92/188 (49%)
		SUFU_C	250..450	CDD:463598	61/291 (21%)