Protein Alignment PDHA2 and Pdha

DIOPT Version :10

• Sequence 1: NP_005381.1
• Gene: PDHA2 / 5161
• HGNCID: 8807
• Length: 388
• Species: Homo sapiens
• Sequence 2: NP_726945.1
• Gene: Pdha / 31406
• FlyBaseID: FBgn0028325
• Length: 443
• Species: Drosophila melanogaster
• Alignment Length: 364
• Identity: 206/364 - (56%)
• Similarity: 264/364 - (72%)
• Gaps: 2/364 - (0%)

Human    15 QKSARRVLVASRNSSNDATFEIKK-CDLYLLEEGPPVTTVLTRAEGLKYYRMMLTVRRMELKADQ 78
            |.:|:..:..:.|.:.:||.::.: ..|:.|:|||.....||:.:.||||..|.|:||:|..|..
  Fly    64 QNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGN 128

Human    79 LYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSILAELTGRRGGC 143
            |||:|.|||||||..|||||.||::|.:...|::|::||.||..|..|:|...:||||||.:|||
  Fly   129 LYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGC 193

Human   144 AKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGAANQGQIAEAFNM 208
            |:|||||||||..||||||||||||.|||||:.||||||||..:||.|||||||||||:.||:||
  Fly   194 ARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNM 258

Human   209 AALWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRS 273
            |.|||||.:|:||||.||||||:|||:.:.|||.||:.:||:.|||||||.||.||:||.||..:
  Fly   259 AYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNT 323

Human   274 GKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGA 338
             .||::||..||||.||||||||.||||||||||||.|||||...::..:...|.|.:|:|.|..
  Fly   324 -HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDL 387

Human   339 EVRKEIDDAAQFATTDPEPHLEELGHHIYSSDSSFEVRG 377
            :||||:|:|..||.:|.|..:..|...:||::...::||
  Fly   388 KVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDHA2	NP_005381.1	PDH_E1_alph_y	56..368	CDD:274473	190/311 (61%)
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:470272	201/348 (58%)