DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDHA2 and Pdha

DIOPT Version :9

Sequence 1:	NP_005381.1	Gene:	PDHA2 / 5161	HGNCID:	8807	Length:	388	Species:	Homo sapiens
Sequence 2:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	206/364 - (56%)
Similarity:	264/364 - (72%)	Gaps:	2/364 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    15 QKSARRVLVASRNSSNDATFEIKK-CDLYLLEEGPPVTTVLTRAEGLKYYRMMLTVRRMELKADQ 78
            |.:|:..:..:.|.:.:||.::.: ..|:.|:|||.....||:.:.||||..|.|:||:|..|..
  Fly    64 QNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGN 128

Human    79 LYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSILAELTGRRGGC 143
            |||:|.|||||||..|||||.||::|.:...|::|::||.||..|..|:|...:||||||.:|||
  Fly   129 LYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGC 193

Human   144 AKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGAANQGQIAEAFNM 208
            |:|||||||||..||||||||||||.|||||:.||||||||..:||.|||||||||||:.||:||
  Fly   194 ARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNM 258

Human   209 AALWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRS 273
            |.|||||.:|:||||.||||||:|||:.:.|||.||:.:||:.|||||||.||.||:||.||..:
  Fly   259 AYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNT 323

Human   274 GKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGA 338
             .||::||..||||.||||||||.||||||||||||.|||||...::..:...|.|.:|:|.|..
  Fly   324 -HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDL 387

Human   339 EVRKEIDDAAQFATTDPEPHLEELGHHIYSSDSSFEVRG 377
            :||||:|:|..||.:|.|..:..|...:||::...::||
  Fly   388 KVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDHA2	NP_005381.1	PDH_E1_alph_y	56..368	CDD:274473	190/311 (61%)
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	201/348 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143841
Domainoid	1	1.000	403	1.000	Domainoid score	I724
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129539
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1648
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm8483
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2211
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750