DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDHA1 and CG7024

DIOPT Version :9

Sequence 1:	NP_001166925.1	Gene:	PDHA1 / 5160	HGNCID:	8806	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_572182.1	Gene:	CG7024 / 31407	FlyBaseID:	FBgn0029722	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	194/384 - (50%)
Similarity:	255/384 - (66%)	Gaps:	11/384 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    50 SHS-LKTRQASRVLVASRNFANDATFE-IKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRM 112
            :|| |:.....|::  .|:..:..|.| ..||  :.||.||.:...|:|||.|..|..|..:||.
  Fly    16 AHSILERNMLCRII--GRHKCSCLTLENTFKC--YDLENGPTMDVELSREDALTMYTQMLELRRF 76

Human   113 ELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELT 177
            |..|...||::.|||||||.:||||..||::..:...|.:|||||.|.:|:..|:|:.||:|||.
  Fly    77 ETVAGNYYKERKIRGFCHLYNGQEAVAVGMKQRLRSCDSVITAYRCHAWTYLMGVSLYEIMAELF 141

Human   178 GRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQI 242
            |.:.||::|||||||||:..||||||||||||||||||.||..|...:.|.:.||||||||||||
  Fly   142 GVRTGCSRGKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQI 206

Human   243 FEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFA 307
            ||::|||.||.|||||:||||.|||||.|:||:|.|::|.||.:||||.|||..:|.||.||:||
  Fly   207 FESFNMAKLWCLPCIFVCENNHYGMGTHVKRASAMTEFYMRGQYIPGLWVDGNQVLAVRSATQFA 271

Human   308 AAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEE 372
            ..:... .|||::|:.||||.||||||||.|||:|||:|..|.|.|||...:.:::...||..||
  Fly   272 VDHALK-HGPIVLEMSTYRYVGHSMSDPGTSYRSREEVQSTREKRDPITSFRSQIIALCLADEEE 335

Human   373 LKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGAN----QWIKFKSV 427
            ||.:|.:.||:::...:.||.|.|..|:||...||:.:...::||.:    :.||...|
  Fly   336 LKALDDKTRKQVDSICKKATTDREVELDELHTDIYAKNVDGKIRGVSGFHLEHIKLAEV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDHA1	NP_001166925.1	PDH_E1_alph_y	96..408	CDD:274473	174/311 (56%)
CG7024	NP_572182.1	TPP_enzymes	37..381	CDD:294952	185/346 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		mtm8483
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	LDO	PTHR11516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.670