Protein Alignment PDGFRB and Ret

DIOPT Version :9

• Sequence 1: NP_002600.1
• Gene: PDGFRB / 5159
• HGNCID: 8804
• Length: 1106
• Species: Homo sapiens
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 1068
• Identity: 254/1068 - (23%)
• Similarity: 395/1068 - (36%)
• Gaps: 332/1068 - (31%)

Human    99 FCTHNDSRGL--------ETDERKRLYIFVPDPTVGFLPNDA--EELFIFLTEITEITIPCRVTD 153
            :..||||.||        |.|...|.:..| ...:.|..|..  |..:....|..::||..||..
  Fly   304 YAVHNDSHGLFRPDCHAYEADHTGRPHTIV-SCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDA 367

Human   154 PQLVVT---------LHEKKGDV--ALPVPYDHQR-----GFSGIFEDRSYICKTTIGDREVDSD 202
            ......         |||.:.::  |||:.....|     .|:|....||....|...|::|.
  Fly   368 MSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVS-- 430

Human   203 AYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLD 267
               |||...|                               ||          |:|:|  |..||
  Fly   431 ---VYRSAAS-------------------------------NF----------RVVQP--DSFLD 449

Human   268 MPYHIRSI-LHIPSAELEDSG-TYTCNVTESVNDHQDEKA------INITVVES---GYVRLLG- 320
            : ..:||| ..|...:|...| |.|..:....|....|:|      :|:|.::.   .:||::.
  Fly   450 L-MRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINV 513

Human   321 -------EVGTLQFAELHRSRT-LQVVFE---------AYPPPTVLWFKDNRTLGDSSAGEIALS 368
                   |..:.:.....||:| .|:.::         |....:..|...|..:..:..|..
  Fly   514 HLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSC--- 575

Human   369 TRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLE-LSESHPDSGEQ 432
               |.|:||                                     .|..|.: |.|.:|.:..|
  Fly   576 ---VPESRY-------------------------------------CPDHVCDPLEELNPMACPQ 600

Human   433 TVRCRGR--GMPQPNI----IWSA-----CRDLKRC--------PRELPPTLLGNSSEEESQLET 478
            .....||  |....|.    |:||     |.|..:|        |:...|....|.:|.|
  Fly   601 DCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAE----- 660

Human   479 NVTYWEEEQEFEVVSTLRLQHVDRPLS--VRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILAL 541
                       .::...|....::||.  :...:.|..|.:..      .|..|.|:....:..|
  Fly   661 -----------PLLGVRRGTPPNQPLQDPMLLGVLNVAGFECD------RSCMFFVITCPLLFVL 708

Human   542 VVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPY-----DSTWELPRDQLV 601
            ::|.:: :....||.::..:..:.....:::...|.....:.|:|..:     |:.||.||::|.
  Fly   709 LLLCLL-IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQ 772

Human   602 LGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVN 666
            |...||.|.||||::..|..::.......|||||||..:.|.|..||:||.:::..:. |.||:.
  Fly   773 LDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIK 836

Human   667 LLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVS 731
            ||||||......:|.||.|||.|..||..::
  Fly   837 LLGACTSSEAPLLIIEYARYGSLRSYLRLSR---------------------------------- 867

Human   732 LTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESP 796
                                        .::.|.::.::.:.|                 :|...
  Fly   868 ----------------------------KIECAGVDFADGVEP-----------------VNVKM 887

Human   797 VLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKG 861
            ||:      |::|:..||.:|:....|||||||||||:.:||:.||.||||.||:..|..|:.:.
  Fly   888 VLT------FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRS 946

Human   862 STFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPEL-PMNEQFYNAIKRGYRMAQ 925
            ...:|:|||||||:.:.:||:.|||||||:|.||:.|||.:|||.: |.|  .::.:|.||||.:
  Fly   947 RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQN--LWSLLKTGYRMDR 1009

Human   926 PAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQA 990
            |.:.|:.:|.|::.||.::...||.|..|....|:|||...|    .:|
  Fly  1010 PENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK----YID---------------- 1054

Human   991 RLPGFHGLRSPLDTSSV---LYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEV 1052
                       |:|::|   ||.      ||:..:|.....:||....  |...|.:|....::.
  Fly  1055 -----------LETNAVSNPLYC------GDDSALITTELGEPESLQH--LWSPPKIAYDIHDQA 1100

Human  1053 NTSSTISCDSPLEPQDEPE---PEPQLE 1077
            .:......:.|:.....|.   |.|.|:
  Fly  1101 TSYDQSEEEMPVTSTAPPGYDLPRPLLD 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDGFRB	NP_002600.1	ig	37..114	CDD:278476	8/22 (36%)
		IG	40..110	CDD:214652	6/18 (33%)
		IG_like	222..310	CDD:214653	20/95 (21%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	21/91 (23%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	15/118 (13%)
		Ig	425..523	CDD:299845	22/118 (19%)
		PTKc_PDGFR_beta	562..953	CDD:133238	124/396 (31%)
		Pkinase_Tyr	600..953	CDD:285015	116/353 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1019..1106		11/62 (18%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	121/366 (33%)
		TyrKc	771..1042	CDD:197581	117/358 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910