DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDGFRB and Eph

DIOPT Version :10

Sequence 1:NP_002600.1 Gene:PDGFRB / 5159 HGNCID:8804 Length:1106 Species:Homo sapiens
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1086 Identity:219/1086 - (20%)
Similarity:372/1086 - (34%) Gaps:399/1086 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    31 QGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMS--QEPPQ----EMAKAQDGTFSSVLTLTN 89
            ||..::      ||.| ..:.:||    |.|.|..:  .|.|.    .:.:.|:||     .:.|
  Fly   245 QGACIS------VLAV-KVYYITC----PAVTENFAHFNETPTGREITIIEKQNGT-----CVDN 293

Human    90 LTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEE------LFIFLT-EITEITI 147
            ....:|..|.|..:....:.|...:        ...|:.||...:      |..|.: |:|:.| 
  Fly   294 AEPYETPTYLCKGDGKWTILTGGCR--------CKAGYEPNYTNKTCTECPLGTFKSPEVTKCT- 349

Human   148 PCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYV--YRLQ 210
            ||                      |.:.....:|     |..||...|.....:|..::  |   
  Fly   350 PC----------------------PPNSNASKTG-----SPFCKCASGFYRHPNDGRHMPCY--- 384

Human   211 VSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTD-FLLDMPYHIR- 273
                  |..|..|      |:||:.:...:.:::  |:.|.|......|..:. :..|:.|.|: 
  Fly   385 ------SPPAAPT------NLTLLFVDQTSAIIS--WSAPAKNESFSSETNSKIYHSDIVYKIKC 435

Human   274 -----SILHIPSAE-----------LEDSGTYT-----CNVTESVND---HQDEKAI----NITV 310
                 ::::.||.:           ||...|||     .|....:|:   |.:|.::    :|..
  Fly   436 NICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVF 500

Human   311 VESGYVRL---LGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNV 372
            ..:..:.:   |.||.|.|         .::||                    :...:.|||   
  Fly   501 SNTSLLNIPLDLNEVKTGQ---------AEIVF--------------------TTESVLLST--- 533

Human   373 SETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCR 437
                 |..|.::.:.            ::||:::....:|.:.|:...|:               
  Fly   534 -----VFNLRILAIT------------NKDADLEWDKPVQSDFPLEFYEV--------------- 566

Human   438 GRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDR 502
             |..|:..:                      .:..:|.|.|      :|.:..:|..  |::.:.
  Fly   567 -RWFPKVEL----------------------DAINKSALNT------KETKAHIVGL--LENTEY 600

Human   503 PLSVRCTLRNAVG--------QDTQEV-IVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQK 558
            ...|||...|..|        |..|.| .|...|:..:.:. .||:..|:..:|.:|..:...:.
  Fly   601 GFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIA-GAIVTGVLFLVIFIIATVYFMRS 664

Human   559 KPRYEIRWK-------------------------------VIESVSSDGHEYI----YVDPMQLP 588
            |.:.::..|                               |...:..:...|:    |.||.|..
  Fly   665 KHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAI 729

Human   589 YDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELK 653
            .:...|:..:.:.:...:|.|.||.|.........:....:.||:|.||..:....:...::|..
  Fly   730 REFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794

Human   654 IMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSN 718
            ||... .|.||:.|.|..|:..|:.|||||...|.|..:|..|                      
  Fly   795 IMGQF-DHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN---------------------- 836

Human   719 ALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAP 783
                              ||      |.:::..:.||  :|                        
  Fly   837 ------------------DG------KFQTLQLIVML--RG------------------------ 851

Human   784 ERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLA 848
                                      :|:||.:|:..|.|||||||||||:....:.||.||||:
  Fly   852 --------------------------IASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLS 890

Human   849 RDIMRDSN-YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ 912
            |:|...|: |.::|.. :|::|.|||:|....:|:.|||||:|::|||:.:.|..||... .|:.
  Fly   891 REIENASDAYTTRGGK-IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNW-SNQD 953

Human   913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
            ...:|::|||:..|....:.:|::|..||:::...||.|:.:|..|:.|                
  Fly   954 VIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL---------------- 1002

Human   978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYII 1023
                        ||.|           .|:|.|...| |.|.::|:
  Fly  1003 ------------ARQP-----------QSLLTTRPSP-ESDGNHIL 1024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDGFRBNP_002600.1 ig 37..114 CDD:395002 18/82 (22%)
Ig strand B 50..54 CDD:409353 0/3 (0%)
Ig strand C 60..63 CDD:409353 1/2 (50%)
Ig strand E 83..87 CDD:409353 0/3 (0%)
Ig strand F 97..101 CDD:409353 1/3 (33%)
IgI_PDGFR-alphabeta 212..311 CDD:409447 25/128 (20%)
Ig strand A 212..216 CDD:409447 0/3 (0%)
Ig strand A' 223..227 CDD:409447 1/3 (33%)
Ig strand B 229..238 CDD:409447 3/8 (38%)
Ig strand C 243..248 CDD:409447 0/4 (0%)
Ig strand C' 251..253 CDD:409447 0/1 (0%)
Ig strand D 257..265 CDD:409447 1/8 (13%)
Ig strand E 270..278 CDD:409447 2/13 (15%)
Ig strand F 288..294 CDD:409447 4/10 (40%)
Ig strand G 299..305 CDD:409447 2/8 (25%)
Ig4_PDGFR 314..415 CDD:409445 15/103 (15%)
Ig 431..519 CDD:472250 14/95 (15%)
Ig strand B 432..436 CDD:409353 0/3 (0%)
Ig strand C 445..449 CDD:409353 0/3 (0%)
Ig strand E 493..497 CDD:409353 0/3 (0%)
Ig strand F 504..510 CDD:409353 3/5 (60%)
PTKc_PDGFR_beta 562..953 CDD:133238 102/426 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1106 1/5 (20%)
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 5/21 (24%)
FN3 387..476 CDD:238020 19/96 (20%)
FN3 536..623 CDD:238020 19/144 (13%)
EphA2_TM 640..738 CDD:464211 14/98 (14%)
PTKc_EphR 736..1002 CDD:270629 96/366 (26%)
SAM_1 1029..1092 CDD:425739
Blue background indicates that the domain is not in the aligned region.

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