DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDGFRB and btl

DIOPT Version :10

Sequence 1:NP_002600.1 Gene:PDGFRB / 5159 HGNCID:8804 Length:1106 Species:Homo sapiens
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:1022 Identity:265/1022 - (25%)
Similarity:390/1022 - (38%) Gaps:327/1022 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   187 SYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQ------TVVRQGENITLMCIVIGNEV-VN 244
            ||.|:..:   |.|.......:|:|.|...:|..::      |.:..|:|:::.|::..:.: ..
  Fly   211 SYHCELCV---EQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPK 272

Human   245 FEWTYP------------RKESGRLVEPVTDFL--LDMPYHIRSILHIPSAELEDSGTYTCNVTE 295
            ..|.:.            .:|..:|...||..:  :|.|    .:|.:.:..:||.|.|.|....
  Fly   273 ITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEP----QVLRLGNVLMEDGGWYICIAEN 333

Human   296 SVN-----------DHQDEKAINITV--------------------VESGYVRLLGEVGTLQF-A 328
            .|.           ...|...:..|.                    ||:......|.||...| .
  Fly   334 QVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRK 398

Human   329 ELHR------SRTLQVVFEAYPPPTVLWFKD----NRTLGDSSAGEIALSTRNVSETRYVSE--- 380
            ||.|      ..|:.:....|....:.|.||    ||.||                 .||.:   
  Fly   399 ELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELG-----------------VYVQKNWT 446

Human   381 LTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQIN-----VPVRVLELSESHPDSGEQTVRCRGRG 440
            |..|.....::|.|..:..:....:|..|.:|||     .|:.|:..:::...:|...::|....
  Fly   447 LRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYS 511

Human   441 MPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLS 505
            ...|.:.|... .||..      :|.|..|.|...|...||      ...||.|||....|:...
  Fly   512 DLHPTVSWKRV-VLKNA------SLDGLKSVEIQNLNFTVT------NDSVVLTLRNVTFDQEGW 563

Human   506 VRCTLRNAVGQDTQEV---IVVP------------HSLPFKVVVISAILALVVLTIISLIILIML 555
            ..|...:.:|:....|   :|.|            |.|.|.:..|: |:||.:|.  |..|..||
  Fly   564 YTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAIT-IVALFLLG--SAFITFML 625

Human   556 ------------------WQKKP-----------------------RYEIRWKVIESVSSDGHEY 579
                              |.||.                       |.|.:...:.:..:.|   
  Fly   626 RRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGG--- 687

Human   580 IYVDPMQ------LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQ--ATMKVAVKML 636
              .||.|      .|.||.||:||.||.||..||.||||:||.|.|.||..|.  |...|||||:
  Fly   688 --TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMV 750

Human   637 KSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFL 701
            |.....::..:|:.|:::|..:|.|:|::||||.|::|||:::|.||..:|:|.|:|.:|:....
  Fly   751 KEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAP 815

Human   702 QHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADI 766
            |..||                             || ||:|                        
  Fly   816 QRRSD-----------------------------SD-GYLD------------------------ 826

Human   767 ESSNYMAPYDNYVPSAPERTCRATLINESPVLSYM-----DLVGFSYQVANGMEFLASKNCVHRD 826
                                       :.|::|..     :|..|::|:|.|||:|||:.|:|||
  Fly   827 ---------------------------DKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRD 864

Human   827 LAARNVLICEGKLVKICDFGLARDIMRDSNYISKGST-FLPLKWMAPESIFNSLYTTLSDVWSFG 890
            |||||||:.:|.::||.|||||||| :|:.|..|.:. .||:|||||||:....|.:.|||||:|
  Fly   865 LAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYG 928

Human   891 ILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLV 955
            :|||||.|.|..|||.:...|:.|:.:..|.||.:||..|..||.:|::||..:...||.|::||
  Fly   929 VLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELV 993

Human   956 LLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND 1020
                    |.:....||...                                     .||:...|
  Fly   994 --------ESFDGILQQASS-------------------------------------NPNDAYLD 1013

Human  1021 YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQ 1067
            ..:|:.:..|...||.  :||.   :.|..|.         |||..|
  Fly  1014 LSMPMLETPPSSGDED--DGSD---TETFRET---------SPLRYQ 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDGFRBNP_002600.1 ig 37..114 CDD:395002
Ig strand B 50..54 CDD:409353
Ig strand C 60..63 CDD:409353
Ig strand E 83..87 CDD:409353
Ig strand F 97..101 CDD:409353
IgI_PDGFR-alphabeta 212..311 CDD:409447 22/150 (15%)
Ig strand A 212..216 CDD:409447 1/3 (33%)
Ig strand A' 223..227 CDD:409447 1/3 (33%)
Ig strand B 229..238 CDD:409447 2/8 (25%)
Ig strand C 243..248 CDD:409447 0/4 (0%)
Ig strand C' 251..253 CDD:409447 0/1 (0%)
Ig strand D 257..265 CDD:409447 3/7 (43%)
Ig strand E 270..278 CDD:409447 1/7 (14%)
Ig strand F 288..294 CDD:409447 2/5 (40%)
Ig strand G 299..305 CDD:409447 1/5 (20%)
Ig4_PDGFR 314..415 CDD:409445 27/119 (23%)
Ig 431..519 CDD:472250 20/87 (23%)
Ig strand B 432..436 CDD:409353 0/3 (0%)
Ig strand C 445..449 CDD:409353 0/3 (0%)
Ig strand E 493..497 CDD:409353 2/3 (67%)
Ig strand F 504..510 CDD:409353 1/5 (20%)
PTKc_PDGFR_beta 562..953 CDD:133238 145/404 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1106 13/49 (27%)
btlNP_729956.1 Ig 143..215 CDD:472250 2/3 (67%)
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570 2/3 (67%)
Ig_3 247..333 CDD:464046 17/89 (19%)
Ig 398..479 CDD:472250 20/97 (21%)
Ig strand B 412..416 CDD:409393 0/3 (0%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 1/3 (33%)
Ig strand F 459..464 CDD:409393 1/4 (25%)
Ig strand G 472..475 CDD:409393 1/2 (50%)
IG_like 492..583 CDD:214653 22/103 (21%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 0/3 (0%)
Ig strand E 549..553 CDD:409444 2/3 (67%)
Ig strand F 563..568 CDD:409444 1/4 (25%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 143/389 (37%)
Blue background indicates that the domain is not in the aligned region.

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