DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDGFRB and Pvr

DIOPT Version :10

Sequence 1:NP_002600.1 Gene:PDGFRB / 5159 HGNCID:8804 Length:1106 Species:Homo sapiens
Sequence 2:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster


Alignment Length:1566 Identity:365/1566 - (23%)
Similarity:588/1566 - (37%) Gaps:522/1566 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    10 LALKGELLLLSLLLLLEPQISQGL-----------------------VVTPPGPELVLNVSSTFV 51
            :|:...|:||.|||:|....|..:                       ::||....::|:..::..
  Fly     1 MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTT 65

Human    52 LTCSGSAPVVWERMSQEPPQEMAKAQDGT------FSSVLTLTNLTGLDTGEYFCTHND-----S 105
            |.|....|:.|  .:.:......|:.|.|      |.:.|.|..:|......|:|....     :
  Fly    66 LKCEDDEPMSW--WTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIA 128

Human   106 RGLETDE----------RKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL 160
            :..::||          ...:|::|.||....:  |:..: :...:.|::.|||:...|...|.|
  Fly   129 KEEQSDEAMIELVNQGYASSIYVYVNDPDTKLV--DSHNV-VTARQYTDVVIPCKPAMPDTEVLL 190

Human   161 HEKKGDVALPVP---YDHQRGFS----GIFEDRSYICK------------TTIGDREV------- 199
            ....|::.....   ||.||||:    .|.:...|.|:            |:|..|.:       
  Fly   191 ETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIP 255

Human   200 ---DSDAYYVYRLQVSSINVSVNAVQ-------TVVRQGE------------------------- 229
               .::..|.|...|:..:..|..|.       .::|.|:                         
  Fly   256 RTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPR 320

Human   230 -------------------------NITLMC--IVIGNEVVNFEWTYPRKESGRLV--EPVTDFL 265
                                     |.||.|  ......|...||..|.::..|:.  :..||..
  Fly   321 PGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPK 385

Human   266 LDMPYHI--RSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRL-LGEVGTLQF 327
            .....|.  ||.|.:.:|:..|:|.|.|..|::.|.:.......|.|::.....| :||......
  Fly   386 TRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYN 450

Human   328 AELHRSRTLQVV--FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRN--VSETRYVSELTLVRVKV 388
            .:.:.:||:|:.  ||.:|.|:..|||.:.|       |:..|..|  :..|...:.|.::..::
  Fly   451 VQEYANRTIQMTANFEGFPTPSFSWFKPDGT-------EVRQSENNFKILSTELSTMLQVLNAQL 508

Human   389 AEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGE-QTVRCRGRGMPQPNII----- 447
            .::|.|.:|..:....||..:.:.: :....|::|:::...|. ..:.|..|..| |.|:     
  Fly   509 QDSGTYVLRGSNSFGVVQREYNVSV-MDAPALKMSDAYVQVGSVARLECTVRSYP-PAIVTFFFR 571

Human   448 -------WSACRDLKR---CPRE-------------------------LPP-------------- 463
                   |..|..|.:   .|.|                         ||.              
  Fly   572 PCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIID 636

Human   464 -----------TLLGNSSE----------EESQLETNVTY--------------W----EEEQEF 489
                       .||||.||          .:...|.||.:              |    |:.:|.
  Fly   637 GKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKES 701

Human   490 EVV------------STL---------------RLQHVDR------------------------- 502
            :.|            ||:               |..|.|:                         
  Fly   702 DSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGG 766

Human   503 -------------PLSVRCT----------------------LRNAVGQDTQEVIVVPHSLP--- 529
                         .|.:.|.                      ||:.:.::::  :::.|..|   
  Fly   767 QEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESK--LLITHLYPGDE 829

Human   530 --FK--------------VVVISAI----LALVVLTIISLIILIML-------WQKKPRYEIRWK 567
              :|              .||||.:    :|.|...:|..:|||.|       :||:.:..:..|
  Fly   830 GVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALK 894

Human   568 VIESVSSDGHEYIYVDP--------MQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH 624
            .....:.:.....:::|        ..|||:..:|.||:.|.||:.||:||||.|::..|.|:..
  Fly   895 AAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRR 959

Human   625 SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRY 686
            .:.|..|||||:|:||.:...:||:||||||.|||.||||||||||.||.   ..:.:|.||||:
  Fly   960 EEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRF 1024

Human   687 GDLVDYLHRNKHTFLQH------HSD-----KRRPPSAEL----------YSNALPVGLPLPSHV 730
            |::.::|.||:..|:..      |.|     :|...:.||          |:|   ||.|:.|::
  Fly  1025 GNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYAN---VGFPIHSYI 1086

Human   731 ------------------------SLTGESDGGYMDMSKDESVD-------YVPMLDMKGDVKYA 764
                                    :..|.:..|....|.|..:|       .||..|        
  Fly  1087 NEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDD-------- 1143

Human   765 DIESSNYMAP--YDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDL 827
            .|.|:|.:.|  ..||          .|...|:..::.:||:.:::|||.||::|:||..:|.||
  Fly  1144 QIMSNNSVQPAWRSNY----------KTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDL 1198

Human   828 AARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGIL 892
            ||||:|:||..:||||||||||.:.|..||....:..||:||:|.||:.:.:::|.|||||:||:
  Fly  1199 AARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIV 1263

Human   893 LWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLL 957
            |||:|:|...|||.:..|::.:|.:..||||.:|..|:.|:||||.:||.:..|.||.|::|...
  Fly  1264 LWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKR 1328

Human   958 LERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYI 1022
            ...:|||.....|..::..:::|:...:.:.........|....|..::..|.        |.:|
  Fly  1329 FANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYV--------NGHI 1385

Human  1023 IP------LPDPKPEVA-DEGP-----------LEGS----PSLASSTL-------------NEV 1052
            :|      |||...|:: |..|           |||.    |..:|.|.             |.:
  Fly  1386 VPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNL 1450

Human  1053 NTSSTISCDSPLEPQD----------EPEPEPQLELQ---VEPEPE--------LEQLPDSGCPA 1096
            |:.|:    .||..::          .||..|.|...   .:..||        |:|...:..|:
  Fly  1451 NSGSS----KPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPS 1511

Human  1097 PRAEAE 1102
            ||...|
  Fly  1512 PRHHVE 1517

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDGFRBNP_002600.1 ig 37..114 CDD:395002 17/97 (18%)
Ig strand B 50..54 CDD:409353 1/3 (33%)
Ig strand C 60..63 CDD:409353 0/2 (0%)
Ig strand E 83..87 CDD:409353 1/3 (33%)
Ig strand F 97..101 CDD:409353 1/3 (33%)
IgI_PDGFR-alphabeta 212..311 CDD:409447 27/161 (17%)
Ig strand A 212..216 CDD:409447 0/3 (0%)
Ig strand A' 223..227 CDD:409447 0/3 (0%)
Ig strand B 229..238 CDD:409447 4/60 (7%)
Ig strand C 243..248 CDD:409447 1/4 (25%)
Ig strand C' 251..253 CDD:409447 0/1 (0%)
Ig strand D 257..265 CDD:409447 2/9 (22%)
Ig strand E 270..278 CDD:409447 4/9 (44%)
Ig strand F 288..294 CDD:409447 2/5 (40%)
Ig strand G 299..305 CDD:409447 0/5 (0%)
Ig4_PDGFR 314..415 CDD:409445 24/105 (23%)
Ig 431..519 CDD:472250 34/268 (13%)
Ig strand B 432..436 CDD:409353 0/3 (0%)
Ig strand C 445..449 CDD:409353 1/15 (7%)
Ig strand E 493..497 CDD:409353 2/18 (11%)
Ig strand F 504..510 CDD:409353 2/27 (7%)
PTKc_PDGFR_beta 562..953 CDD:133238 164/455 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1106 32/140 (23%)
PvrNP_001162911.1 IG_like 346..432 CDD:214653 23/85 (27%)
Ig strand C 363..366 CDD:409353 1/2 (50%)
Ig strand E 396..400 CDD:409353 2/3 (67%)
Ig strand F 410..415 CDD:409353 2/4 (50%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 20/81 (25%)
Ig strand B 459..463 CDD:409353 1/3 (33%)
Ig strand C 472..476 CDD:409353 0/3 (0%)
Ig strand E 497..503 CDD:409353 1/5 (20%)
Ig strand F 513..518 CDD:409353 1/4 (25%)
Ig 671..>742 CDD:472250 12/70 (17%)
Ig strand B 674..678 CDD:409353 1/3 (33%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 2/3 (67%)
Ig strand F 731..736 CDD:409353 0/4 (0%)
Ig 779..851 CDD:472250 8/73 (11%)
Ig strand B 781..785 CDD:409570 1/3 (33%)
Ig strand C 794..798 CDD:409570 0/3 (0%)
Ig strand E 816..821 CDD:409570 0/6 (0%)
Ig strand F 831..836 CDD:409570 1/4 (25%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 160/425 (38%)

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