DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDGFRB and Wsck

DIOPT Version :9

Sequence 1:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens
Sequence 2:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	160/809 - (19%)
Similarity:	271/809 - (33%)	Gaps:	294/809 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   281 AELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPP 345
            |.|.....:..||.|. .:.|||:..| |...:...:..|.||...:        ...:....|.
  Fly    77 AVLASEKCFCANVLEP-QEQQDEQLCN-TRCLANKAQYCGGVGVHSY--------YSTILTKQPG 131

Human   346 PTVLWFKDNRTLGDSSAGEIALSTRNV-----SETRYVSELT---LVRVKVAEAGHYTMRAFHED 402
            |..|.. .|:|....:....|...|.:     :|....::|.   |::.:|.:. :.::.||.:.
  Fly   132 PHHLRI-SNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLLDNFLIKAQVLKT-YSSLPAFPQP 194

Human   403 AEVQLSFQLQINVPVRVLELSESHP--------------------DSGEQTVRCRGR-GMPQPNI 446
            ..:..|.:.|       .||::.||                    :.|:.::..... |:|.|
  Fly   195 EFMVQSTETQ-------FELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSP-- 250

Human   447 IWSACRDLKRCPR----ELPPTLLGNSSEEESQLETNVTY----------------WEEEQE--- 488
            :.:..:.|.|..|    ||.|  :.|.:...|:|...|.|                |::.|:
  Fly   251 VPAQPKILSRTDRTVTIELSP--IRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSWQQAQQDGV 313

Human   489 -FEVVSTLRLQHVDRPLSVRCTLRNAVGQD------TQEVIVVPH-------------------- 526
             :.:.:.|   ..|||...| |.|..||..      |.:.:..|.
  Fly   314 PYYIAAEL---DYDRPEDNR-TRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTM 374

Human   527 -----------SL-PFKVVVI----SAILALVVLTII--SLIILIMLWQKKPRYEIRWKVIES-- 571
                       || .|.....    |:::||.|..:|  |.::|.::    ..:.:|:|....
  Fly   375 YSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLI----AYFYLRYKTCRGRR 435

Human   572 -VSSDGHEYIYVDPM-------------QLPY-------------DSTWELPRDQLVL--GRTLG 607
             ...:.||.....|:             .||:             :....:||:.|.|  ...:|
  Fly   436 LTGGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIG 500

Human   608 SGAFGQVV-----------EATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPH 661
            .|.||:::           :.|.|.|         .:..|..|.::.    |:.||:.:|.|...
  Fly   501 DGRFGEIITGKVSTNDFARDCTLHVL---------CLDDLNGTTQAQ----LLRELRQLSQLKRQ 552

Human   662 LNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPL 726
            .::::..|........|:|.|.                  |..|.||:
  Fly   553 EHLLDFYGVSASPDWFYLIFEQ------------------QRMSLKRK----------------- 582

Human   727 PSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATL 791
                                                   :..|..|||       :|    |.|.
  Fly   583 ---------------------------------------LVESRLMAP-------SP----RLTS 597

Human   792 INESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFG------LARD 850
            ::|..||.::      |::|:.|.:|:|...|||.|.:.:|.:.....:|:..||      :||.
  Fly   598 LSEQLVLQWI------YELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ 656

Human   851 IMRDSNYISKGSTFLPLKWMAPESI-FNSLYTTLSDVWSFGILLWEIFTLGGTPYPE-LPMNEQF 913
             ..|.|           :|:|||.: ....::|.|||||...:.||...||||||.. :..|:|.
  Fly   657 -QPDHN-----------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQL 709

Human   914 YNAIKRGYRMAQPAHASDEIYEIMQKCWE 942
            ..||:...|.||||:...::|:::..||:
  Fly   710 LEAIRAAVRPAQPAYVYGDLYQLLLNCWQ 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653	9/28 (32%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	10/30 (33%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	18/108 (17%)
		Ig	425..523	CDD:299845	29/148 (20%)
		PTKc_PDGFR_beta	562..953	CDD:133238	90/431 (21%)
		Pkinase_Tyr	600..953	CDD:285015	81/364 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106
Wsck	NP_733018.1	WSC	42..115	CDD:280068	10/39 (26%)
		fn3	130..222	CDD:278470	19/100 (19%)
		TyrKc	493..746	CDD:197581	80/362 (22%)
		PTKc	497..750	CDD:270623	79/358 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900