Protein Alignment PIAS4 and Su(var)2-10

DIOPT Version :10

• Sequence 1: XP_011526362.1
• Gene: PIAS4 / 51588
• HGNCID: 17002
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 209/568 - (36%)
• Similarity: 302/568 - (53%)
• Gaps: 101/568 - (17%)

Human     2 TSSLPAKALGHFQKKHLVCKPFCFLHKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQ 66
            |||.|.........|:..|       :.||...||.:||.:|.|:..|.:|.|.:|.:|.|..::
  Fly    27 TSSAPIAVNPFDSTKYKEC-------EQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLR 84

Human    67 FDCSPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPL----AGPNIDY 127
            .:.. .|..|::|:|.....::|:     ..:.:||..|:|.......|...|:    :|..:..
  Fly    85 TNLE-LLAPKVQEVYAQSVQEQNA-----TLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQV 143

Human   128 PVLYGKYLNGLGRLP---------AKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPC 183
            |   |..:|.:|..|         ...:.|:|||.||.|:::|..|:||:.|||:|.:::||.|.
  Fly   144 P---GGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPF 205

Human   184 IFALTPRQVELIRNSRELQPGVK---AVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGY 245
            .|.|||:|...|.::|:::...|   |:||.||.|..:|||.|||.:|||:.||||:..|.:|..
  Fly   206 YFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNV 270

Human   246 YPSNKPGVEPKRPCRPINLTHLMYLS-SATNRITVTW-GNYGKSYSVALYLVRQLTSSELLQRLK 308
            .|:|:|.||||||.||:|:|..:.|| :.||.|||.| .:|.:||.:|:|||::|||::||||:|
  Fly   271 IPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMK 335

Human   309 TIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYL 373
            |.|||..:..:.|:||||..|.|.|||||.::|||.|||.||::.:||||.||:|||||||..||
  Fly   336 TKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYL 400

Human   374 QMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSEC---EDADEIEYLVDGSWCP--IRAEKERS 433
            ||||:||||.||||||||.||.|:|||...::|...   .|..||:...||||..  :|:|.:
  Fly   401 QMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQ-- 463

Human   434 CSPQGAILVLGPSDANGLLPAPSVNGSGALGSTGGGGPVGSMENGKPG------ADVVDLTLDSS 492
                             :|..||                      ||.      :|.::|..|.:
  Fly   464 -----------------ILDTPS----------------------KPAQKVEVISDDIELISDDA 489

Human   493 -------SSSEDEEEEEEEE--------EDEDEEGPRPKRRCPFQKGL 525
                   |.::||:......        .|.|::.|..|||.|.::.:
  Fly   490 KPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAV 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIAS4	XP_011526362.1	SAP	31..65	CDD:128789	13/33 (39%)
		PINIT	153..296	CDD:464136	70/147 (48%)
		SP-RING_PIAS4	337..394	CDD:438470	40/56 (71%)
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	175..323	CDD:464136	70/147 (48%)
		SP-RING_PIAS	369..416	CDD:438444	34/46 (74%)