Protein Alignment PDE6B and Pde8

DIOPT Version :10

• Sequence 1: XP_054206142.1
• Gene: PDE6B / 5158
• HGNCID: 8786
• Length: 1022
• Species: Homo sapiens
• Sequence 2: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Alignment Length: 972
• Identity: 189/972 - (19%)
• Similarity: 324/972 - (33%)
• Gaps: 319/972 - (32%)

Human    78 EEQARSF------------LDQNPDF-ARQYFGKKLS-PENVAAACEDGCPPDCDSLRDLCQVEE 128
            ||:.|:|            |..||.. |...|.|..| .|.:.|||:       ....|:..|:.
  Fly   284 EEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQ-------RHQLDVTLVKS 341

Human   129 STALLELVQ--------------DMQESINME-RVVFKVLR-----RLCTLLQADRCSLFMYRQR 173
            ....|:.:|              |.:.|.|:: ..:.:.:|     .|.|::...:.|.|
  Fly   342 KEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFF----- 401

Human   174 NGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKM----VNVEDVAEC---P 231
                         :.|.||           :..||.||...||:|..:    |.::.:...   |
  Fly   402 -------------EKDDVL-----------IALLDAGVNRCVAETTNLAMCSVELKQILHSIIRP 442

Human   232 HFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIY 296
            |        ....|:..|.|.:...|:||.:              .|:.:.::|.|.||..|
  Fly   443 H--------NVMSTQQALYTALHRLKEVVLI--------------TDDLLRIQYANRATERL--- 482

Human   297 HLSYLHNCETRRGQVLLWSANKVF-EELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKE-- 358
                   ...|..:::......:| .:|:.|..|..          |.:.:. |:|.:.::.:
  Fly   483 -------LNMRLDEIISKQLEDIFVSDLSTISEQCK----------NIKEFD-GILTVRRKSQEG 529

Human   359 ----------------------FFDV----WSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGK 397
                                  .|||    ...:....||...||..              ||..
  Fly   530 IPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGS--------------LHSV 580

Human   398 E----EIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLS 458
            .    :::.|.:......:||. |.|...|:. |..|:|.    :.:.||....|...||..||.
  Fly   581 RRCSFDVRSIASDGLRRTSLAK-LTSLPLEAP-ITKIINL----LSQVQENCSADEARLIDKVLE 639

Human   459 MPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES--LTQFLGWSVMNTDTYDKMNKLENRKDIA 521
                            :.:::|....:..|:..:.  .|..:|..:.....|.....       :
  Fly   640 ----------------FLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRS-------S 681

Human   522 QDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 586
            .|.::......|  ...|:|  |::...|.      :.|:|.|.|  ...|||::..    |.|:
  Fly   682 NDSIIRTGSSTR--TAAIVP--AKMKSNPI------IMELLDESL--SWDFDIFKLE----EITD 730

Human   587 L-DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRI-TYHNWRHGFNVAQT--MFTLLM 647
            . .|:..|::|:....|.....|.:.|...:|..|...||:. ||||..|..:|.|.  .|...:
  Fly   731 YHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQL 795

Human   648 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKFL 709
            |.|.......:|....:.|...||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..
  Fly   796 TNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLT 859

Human   710 LSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKCAPSGRGRLAGRAGSLGPPADTGAQ-R 773
            |.::.:||::||::..::.....:...|:||::..:|:       .||......|     |.: |
  Fly   860 LGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFE-------HLAKFVSVFG-----GEEPR 912

Human   774 RHSPGDAAPDSVPARRPRAPRMGPRSGSAPPCRRALGAGSPHLLPPAPPLFPGFRKRAMFQKIVD 838
            .|:|......|:..||
  Fly   913 DHNPQTDEETSILMRR------------------------------------------------- 928

Human   839 ESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERT 903
                                       |::...|:|...:|.:...:.|..:|.|::.|.|.|:.
  Fly   929 ---------------------------MLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ 966

Human   904 VLDQQPI--PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILP-MFDRLQNNRKEWK 962
              ...||  ||.|| ....:||.|:|||:::...:...:..|.:  :| :...:|.|..:||
  Fly   967 --RHLPIVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFID--MPQLITYMQINYSQWK 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE6B	XP_054206142.1	GAF	144..303	CDD:214500	31/171 (18%)
		GAF	325..512	CDD:214500	35/220 (16%)
		PDEase_I	629..954	CDD:459723	69/333 (21%)
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	20/127 (16%)
		PDEase_I	775..1016	CDD:459723	69/334 (21%)