Protein Alignment PDE6B and Pde11

DIOPT Version :10

• Sequence 1: XP_054206142.1
• Gene: PDE6B / 5158
• HGNCID: 8786
• Length: 1022
• Species: Homo sapiens
• Sequence 2: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 940
• Identity: 270/940 - (28%)
• Similarity: 435/940 - (46%)
• Gaps: 186/940 - (19%)

Human    39 HCRCQAGDTQDRPSMGFLGVHACLEQQRLQGQAATMSLSEEQARSFLDQNPDFARQYFGKKLSPE 103
            |...|||......|:|..|        ...|.....||..........|.|     |:.....|:
  Fly   340 HSHYQAGGAVGSSSLGSTG--------GASGAGGAPSLGGSGGAGNGHQYP-----YYHCHQRPQ 391

Human   104 NVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLF 168
            .:             |..:|.|::|...:.|||:|:...:.:..:..|:|:.:..||.|||.|||
  Fly   392 RL-------------SRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLF 443

Human   169 MYRQR----NGVAE-LATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVA 228
            :.:.|    :|:.: |.::||.|.|.|.:|:  :....|:......|:.||||::.:.||:.|..
  Fly   444 LVQGRCNGPDGLKKCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAY 506

Human   229 ECPHFSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLY 292
            :...|:...|.||.|:||.:|..||.:.. ||:.|...:||:||..|:..||.||..||.|..:.
  Fly   507 QDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIG 571

Human   293 LK---IYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMT 354
            |:   :|..|.|   |.:|.||||..|..:|||.:.||....:....:::.:.|:|..:
  Fly   572 LRNAQLYEKSQL---EIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQI------ 627

Human   355 KEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILH--GKEEIKVIPTPSADHWALASGL 417
                      :|:.|:...|           |.:|.|:..:  .:||.....:|....:.:..|:
  Fly   628 ----------LLVHEADKGS-----------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGI 671

Human   418 PSYVAESGFICNIMNASADEMFKFQEGALDD-SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 481
            ..:||.:|...|:.||..|:.|   :.::|: |.:..:::|.|.|.|...:|:||....|:.:..
  Fly   672 TGHVATTGETVNVPNAYEDDRF---DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNEL 733

Human   482 PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARL 546
            .|.:.||..:|:...|.|..:.||..|:|......::.:..:::.||
  Fly   734 DFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYH------------------ 780

Human   547 GKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 611
                |....||...:.:..:|....|.:::|.|.|:...:.|.:|..::|:.:|..|.:|.|..|
  Fly   781 ----ASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYE 841

Human   612 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRG 676
            ||.|:|.|:.|.||.:|||||||.|||||.||.:|.|.:....:.::|..|::...||||:||||
  Fly   842 VLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRG 906

Human   677 TNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATD 741
            |||.:|:|:.:|||:|:.:|.:|.||.:....:|:.....|..||:...:..||.:::.||::||
  Fly   907 TNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTD 971

Human   742 LALYFKCAPSGRGRLAGRAGSLGPPADTGAQRRHSPGDAAPDSVPARRPRAPRMGPRSGSAPPCR 806
            ||:|||
  Fly   972 LAVYFK----------------------------------------------------------- 977

Human   807 RALGAGSPHLLPPAPPLFPGFRKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC 871
                                  ||..|.:.|.:..:|     ||    .|..| .::.||.||.|
  Fly   978 ----------------------KRGPFLESVSQPTSY-----WV----AEEPR-ALLRAMSMTVC 1010

Human   872 DLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 936
            ||||||||||::.:||.||::||:||||:|:..|:..||.:|:|.|..|||.:||.|||.:|..:
  Fly  1011 DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPI 1075

Human   937 YKEFSRFHEEILPMFDRLQNNRKEWKALAD 966
            |:.|:...:::.|:.:.:::||..|..|||
  Fly  1076 YEAFATLSDKLEPLVEGVRDNRGHWIDLAD 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE6B	XP_054206142.1	GAF	144..303	CDD:214500	57/167 (34%)
		GAF	325..512	CDD:214500	42/189 (22%)
		PDEase_I	629..954	CDD:459723	106/324 (33%)
Pde11	NP_609885.2	GAF	420..582	CDD:214500	55/163 (34%)
		GAF	611..762	CDD:214500	39/180 (22%)
		PDEase_I	859..1093	CDD:459723	106/324 (33%)