DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDGFRL and drpr

DIOPT Version :9

Sequence 1:	NP_001359002.1	Gene:	PDGFRL / 5157	HGNCID:	8805	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	239	Identity:	40/239 - (16%)
Similarity:	68/239 - (28%)	Gaps:	91/239 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    25 PKNKRPKEP-----GENRIKPTNKKVKPKIPKMKDR--------DSANSAPKTQSIMMQVLDKGR 76
            |.|.....|     .|.|:.|.|  ::.|:.....|        |..|::.:..|..:      .
  Fly   848 PPNHNFDNPVYGMQAETRLLPNN--MRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSI------N 904

Human    77 FQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRL--SVKQNERYGQLTLVNSTSADTG 139
            :.....|.:|.|.:|..:            .|.::.|:..:  .:|..|.|
  Fly   905 YNHDLLTKNLNADRTNPI------------VYNESLKEEHVYDEIKHKEGY-------------- 943

Human   140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAK 204
                           ||..|..|..:|         |...|..:.|..|.           .|.|
  Fly   944 ---------------KDPVKIYSKILF---------PEDEYDHLDYSRPS-----------TSQK 973

Human   205 VTLHREFPA-------KEIPANGTDIVYDMKRGFVYLQPHSEHQ 241
            ...||...|       :|.|:|..::...:.:.....:|..:|:
  Fly   974 PHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHE 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDGFRL	NP_001359002.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64		11/51 (22%)
		IG_like	83..145	CDD:214653	9/63 (14%)
		Ig	293..372	CDD:386229
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900